Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyo...

por Savio-Galimberti, Eleonora, Knollmann, Björn C.
Publicado 2015

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes

por Eschenhagen, Thomas, Mummery, Christine, Knollmann, Bjorn C.
Publicado 2015

Ratiometric imaging of calcium during ischemia-reperfusion injury in isolated mouse hearts using Fura-2

por Venkataraman, Raghav, Holcomb, Mark R, Harder, Rene, Knollmann, Björn C, Baudenbacher, Franz
Publicado 2012

Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

por Hwang, Hyun Seok, Baldo, Marcelo P., Rodriguez, Jose Pindado, Faggioni, Michela, Knollmann, Bjorn C.
Publicado 2019

Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle

por Royer, Leandro, Sztretye, Monika, Manno, Carlo, Pouvreau, Sandrine, Zhou, Jingsong, Knollmann, Bjorn C., Protasi, Feliciano, Allen, Paul D., Ríos, Eduardo
Publicado 2010

Tetrodotoxin-sensitive Na(v)s contribute to early and delayed afterdepolarizations in long QT arrhythmia models

por Koleske, Megan, Bonilla, Ingrid, Thomas, Justin, Zaman, Naveed, Baine, Stephen, Knollmann, Bjorn C., Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B.
Publicado 2018

Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias

por Liu, Bin, Lou, Qing, Smith, Heather, Velez-Cortes, Florencia, Dillmann, Wolfgang H., Knollmann, Björn C., Armoundas, Antonis A., Györke, Sándor
Publicado 2020

Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy

por Radbill, Andrew E., Lei, Lucy Y., Paranjape, Sachin Y., Blackwell, Daniel J., Abraham, Robert L., Chew, Derek S., Raj, Satish R., Knollmann, Björn C.
Publicado 2021

Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease

por Deb, Arpita, Tow, Brian D., Qing, You, Walker, Madelyn, Hodges, Emmanuel R., Stewart, James A., Knollmann, Björn C., Zheng, Yi, Wang, Ying, Liu, Bin
Publicado 2023

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy

por Sequeira, Vasco, Wang, Lili, Wijnker, Paul J.M., Kim, Kyungsoo, Pinto, Jose R., dos Remedios, Cris, Redwood, Charles, Knollmann, Bjorn C., van der Velden, Jolanda
Publicado 2022

Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells

por Belbachir, Nadjet, Wu, Yiyang, Shen, Mengcheng, Zhang, Sophia L., Zhang, Joe Z., Liu, Chun, Knollmann, Bjorn C., Lyon, Gholson J., Ma, Ning, Wu, Joseph C.
Publicado 2023

MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

por Rasmussen, Megan L., Taneja, Nilay, Neininger, Abigail C., Wang, Lili, Robertson, Gabriella L., Riffle, Stellan N., Shi, Linzheng, Knollmann, Bjorn C., Burnette, Dylan T., Gama, Vivian
Publicado 2020

SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release( )

por Tow, Brian D, Deb, Arpita, Neupane, Shraddha, Patel, Shuchi M, Reed, Meagan, Loper, Anna-Beth, Eliseev, Roman A, Knollmann, Björn C, Györke, Sándor, Liu, Bin
Publicado 2021

Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes

por Clemens, Daniel J., Ye, Dan, Wang, Lili, Kim, C.S. John, Zhou, Wei, Dotzler, Steven M., Tester, David J., Marty, Isabelle, Knollmann, Bjorn C., Ackerman, Michael J.
Publicado 2023

Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS

por Hamilton, Shanna, Terentyeva, Radmila, Martin, Benjamin, Perger, Fruzsina, Li, Jiaoni, Stepanov, Andrei, Bonilla, Ingrid M., Knollmann, Björn C., Radwański, Przemyslaw B., Györke, Sandor, Belevych, Andriy E., Terentyev, Dmitry
Publicado 2020

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

por Hill, Adam P., Perry, Matthew D., Abi‐Gerges, Najah, Couderc, Jean‐Philippe, Fermini, Bernard, Hancox, Jules C., Knollmann, Bjorn C., Mirams, Gary R., Skinner, Jon, Zareba, Wojciech, Vandenberg, Jamie I.
Publicado 2016

Contrasting Nav1.8 Activity in Scn10a (−/−) Ventricular Myocytes and the Intact Heart

por Stroud, Dina Myers, Yang, Tao, Bersell, Kevin, Kryshtal, Dymtro O., Nagao, Satomi, Shaffer, Christian, Short, Laura, Hall, Lynn, Atack, Thomas C., Zhang, Wei, Knollmann, Bjorn C., Baudenbacher, Franz, Roden, Dan M.
Publicado 2016

Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

por West, James D., Galindo, Cristi L., Kim, Kyungsoo, Shin, John Jonghyun, Atkinson, James B., Macias‐Perez, Ines, Pavliv, Leo, Knollmann, Bjorn C., Soslow, Jonathan H., Markham, Larry W., Carrier, Erica J.
Publicado 2019

The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

por Blackwell, Daniel J., Faggioni, Michela, Wleklinski, Matthew J., Gomez-Hurtado, Nieves, Venkataraman, Raghav, Gibbs, Chelsea E., Baudenbacher, Franz J., Gong, Shiaoching, Fishman, Glenn I., Boyle, Patrick M., Pfeifer, Karl, Knollmann, Bjorn C.
Publicado 2022

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

por Liu, Bin, Walton, Shane D., Ho, Hsiang‐Ting, Belevych, Andriy E., Tikunova, Svetlana B., Bonilla, Ingrid, Shettigar, Vikram, Knollmann, Bjorn C., Priori, Silvia G., Volpe, Pompeo, Radwański, Przemysław B., Davis, Jonathan P., Györke, Sándor
Publicado 2018