Sparse discriminative latent characteristics for predicting cancer drug sensitivity from genomic features

por Knowles, David A., Bouchard, Gina, Plevritis, Sylvia
Publicado 2019

Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

por Malina, Stephen, Cizin, Daniel, Knowles, David A.
Publicado 2022

LDmat: efficiently queryable compression of linkage disequilibrium matrices

por Weiner, Rockwell J, Lakhani, Chirag, Knowles, David A, Gürsoy, Gamze
Publicado 2023

Large-scale causal discovery using interventional data sheds light on the regulatory network architecture of blood traits

por Brown, Brielin C., Morris, John A., Lappalainen, Tuuli, Knowles, David A.
Publicado 2023

Using epigenomics to understand cellular responses to environmental influences in diseases

por Wattacheril, Julia J., Raj, Srilakshmi, Knowles, David A., Greally, John M.
Publicado 2023

Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo

por Shashaank, N, Somayaji, Mahalakshmi, Miotto, Mattia, Mosharov, Eugene V, Makowicz, Emily A, Knowles, David A, Ruocco, Giancarlo, Sulzer, David L
Publicado 2023

Batch effects and the effective design of single-cell gene expression studies

por Tung, Po-Yuan, Blischak, John D., Hsiao, Chiaowen Joyce, Knowles, David A., Burnett, Jonathan E., Pritchard, Jonathan K., Gilad, Yoav
Publicado 2017

Annotation-free quantification of RNA splicing using LeafCutter

por Li, Yang I, Knowles, David A, Humphrey, Jack, Barbeira, Alvaro N., Dickinson, Scott P., Im, Hae Kyung, Pritchard, Jonathan K
Publicado 2017

Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export

por Tsang, Emily K., Abell, Nathan S., Li, Xin, Anaya, Vanessa, Karczewski, Konrad J., Knowles, David A., Sierra, Raymond G., Smith, Kevin S., Montgomery, Stephen B.
Publicado 2016

Transcriptome Sequencing of a Large Human Family Identifies the Impact of Rare Noncoding Variants

por Li, Xin, Battle, Alexis, Karczewski, Konrad J., Zappala, Zach, Knowles, David A., Smith, Kevin S., Kukurba, Kim R., Wu, Eric, Simon, Noah, Montgomery, Stephen B.
Publicado 2014

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

por Knowles, David A, Burrows, Courtney K, Blischak, John D, Patterson, Kristen M, Serie, Daniel J, Norton, Nadine, Ober, Carole, Pritchard, Jonathan K, Gilad, Yoav
Publicado 2018

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

por Schertzer, Megan D., Stirn, Andrew, Isaev, Keren, Pereira, Laura, Das, Anjali, Harbison, Claire, Park, Stella H., Wessels, Hans-Hermann, Sanjana, Neville E., Knowles, David A.
Publicado 2023

Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues

por Kukurba, Kimberly R., Zhang, Rui, Li, Xin, Smith, Kevin S., Knowles, David A., How Tan, Meng, Piskol, Robert, Lek, Monkol, Snyder, Michael, MacArthur, Daniel G., Li, Jin Billy, Montgomery, Stephen B.
Publicado 2014

Allele-specific expression reveals interactions between genetic variation and environment

por Knowles, David A., Davis, Joe R., Edgington, Hilary, Raj, Anil, Favé, Marie-Julie, Zhu, Xiaowei, Potash, James B., Weissman, Myrna M., Shi, Jianxin, Levinson, Douglas F., Awadalla, Philip, Mostafavi, Sara, Montgomery, Stephen B., Battle, Alexis
Publicado 2017

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

por Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Paul, Rigo, Frank, Gitler, Aaron D.
Publicado 2017

Genetic regulation of gene expression and splicing during a 10-year period of human aging

por Balliu, Brunilda, Durrant, Matthew, Goede, Olivia de, Abell, Nathan, Li, Xin, Liu, Boxiang, Gloudemans, Michael J., Cook, Naomi L., Smith, Kevin S., Knowles, David A., Pala, Mauro, Cucca, Francesco, Schlessinger, David, Jaiswal, Siddhartha, Sabatti, Chiara, Lind, Lars, Ingelsson, Erik, Montgomery, Stephen B.
Publicado 2019

Impact of the X Chromosome and sex on regulatory variation

por Kukurba, Kimberly R., Parsana, Princy, Balliu, Brunilda, Smith, Kevin S., Zappala, Zachary, Knowles, David A., Favé, Marie-Julie, Davis, Joe R., Li, Xin, Zhu, Xiaowei, Potash, James B., Weissman, Myrna M., Shi, Jianxin, Kundaje, Anshul, Levinson, Douglas F., Awadalla, Philip, Mostafavi, Sara, Battle, Alexis, Montgomery, Stephen B.
Publicado 2016

Landscape of stimulation-responsive chromatin across diverse human immune cells

por Calderon, Diego, Nguyen, Michelle L. T., Mezger, Anja, Kathiria, Arwa, Müller, Fabian, Nguyen, Vinh, Lescano, Ninnia, Wu, Beijing, Trombetta, John, Ribado, Jessica V., Knowles, David A., Gao, Ziyue, Blaeschke, Franziska, Parent, Audrey V., Burt, Trevor D., Anderson, Mark S., Criswell, Lindsey A., Greenleaf, William J., Marson, Alexander, Pritchard, Jonathan K.
Publicado 2019

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk

por Gentles, Andrew J., Hui, Angela Bik-Yu, Feng, Weiguo, Azizi, Armon, Nair, Ramesh V., Bouchard, Gina, Knowles, David A., Yu, Alice, Jeong, Youngtae, Bejnood, Alborz, Forgó, Erna, Varma, Sushama, Xu, Yue, Kuong, Amanda, Nair, Viswam S., West, Rob, van de Rijn, Matt, Hoang, Chuong D., Diehn, Maximilian, Plevritis, Sylvia K.
Publicado 2020

Multiset correlation and factor analysis enables exploration of multi-omics data

por Brown, Brielin C., Wang, Collin, Kasela, Silva, Aguet, François, Nachun, Daniel C., Taylor, Kent D., Tracy, Russell P., Durda, Peter, Liu, Yongmei, Johnson, W. Craig, Van Den Berg, David, Gupta, Namrata, Gabriel, Stacy, Smith, Joshua D., Gerzsten, Robert, Clish, Clary, Wong, Quenna, Papanicolau, George, Blackwell, Thomas W., Rotter, Jerome I., Rich, Stephen S., Barr, R. Graham, Ardlie, Kristin G., Knowles, David A., Lappalainen, Tuuli
Publicado 2023