The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord

por Genc, Baris, Gozutok, Oge, Kocak, Nuran, Ozdinler, P. Hande
Publicado 2020

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS

por Gautam, Mukesh, Xie, Edward F., Kocak, Nuran, Ozdinler, P. Hande
Publicado 2019

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

por Jara, Javier H., Gautam, Mukesh, Kocak, Nuran, Xie, Edward F., Mao, Qinwen, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2019

NU-9 improves health of hSOD1(G93A) mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone

por Genç, Barış, Gautam, Mukesh, Helmold, Benjamin R., Koçak, Nuran, Günay, Aksu, Goshu, Gashaw M., Silverman, Richard B., Hande Ozdinler, P.
Publicado 2022

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

por Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Publicado 2022

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

por Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Publicado 2021