Managing the sequence-specificity of antisense oligonucleotides in drug discovery

por Hagedorn, Peter H., Hansen, Bo R., Koch, Troels, Lindow, Morten
Publicado 2017

Refining LNA safety profile by controlling phosphorothioate stereochemistry

por Funder, Erik Daa, Albæk, Nanna, Moisan, Annie, Sewing, Sabine, Koch, Troels
Publicado 2020

Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

por Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.
Publicado 2019

Electronic Structures of LNA Phosphorothioate Oligonucleotides

por Bohr, Henrik G., Shim, Irene, Stein, Cy, Ørum, Henrik, Hansen, Henrik F., Koch, Troels
Publicado 2017

In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations

por Hansen, Henrik Frydenlund, Albaek, Nanna, Hansen, Bo Rode, Shim, Irene, Bohr, Henrik, Koch, Troels
Publicado 2021

Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides

por Pedersen, Lykke, Hagedorn, Peter, Vikeså, Jonas, Karlsen, Signe Tang, Særmark, Pia, Koch, Troels, Lindow, Morten
Publicado 2019

Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides

por Pendergraff, Hannah, Schmidt, Steffen, Vikeså, Jonas, Weile, Christian, Øverup, Charlotte, W. Lindholm, Marie, Koch, Troels
Publicado 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

por Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes
Publicado 2005

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

por Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad
Publicado 2020

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

por Straarup, Ellen Marie, Fisker, Niels, Hedtjärn, Maj, Lindholm, Marie W., Rosenbohm, Christoph, Aarup, Vibeke, Hansen, Henrik Frydenlund, Ørum, Henrik, Hansen, Jens B. Rode, Koch, Troels
Publicado 2010

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

por Hagedorn, Peter H, Pontoppidan, Malene, Bisgaard, Tina S, Berrera, Marco, Dieckmann, Andreas, Ebeling, Martin, Møller, Marianne R, Hudlebusch, Heidi, Jensen, Marianne L, Hansen, Henrik F, Koch, Troels, Lindow, Morten
Publicado 2018

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells

por Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Wang, LiAnn, Ren, Xiao-Qin, Soifer, Harris S., Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Armstrong, Brian, Wang, Zhigang, Bauer, Paul, Rossi, John, Stein, C.A.
Publicado 2015

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

por Stein, C. A., Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S., Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels
Publicado 2010

A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

por Castanotto, Daniela, Zhang, Xiaowei, Rüger, Jacqueline, Alluin, Jessica, Sharma, Ritin, Pirrotte, Patrick, Joenson, Lars, Ioannou, Silvia, Nelson, Michael S., Vikeså, Jonas, Hansen, Bo Rode, Koch, Troels, Jensen, Mads Aaboe, Rossi, John J., Stein, Cy A.
Publicado 2020

Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

por Duschmalé, Jörg, Schäublin, Adrian, Funder, Erik, Schmidt, Steffen, Kiełpiński, Łukasz J., Nymark, Helle, Jensen, Klaus, Koch, Troels, Duschmalé, Martina, Koller, Erich, Møller, Marianne Ravn, Schadt, Simone, Husser, Christophe, Brink, Andreas, Sewing, Sabine, Minz, Tanja, Wengel, Jesper, Bleicher, Konrad, Li, Meiling
Publicado 2022

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides

por Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.
Publicado 2020