HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP

por Sahin, Merve, Wong, Wilfred, Zhan, Yingqian, Van Deynze, Kinsey, Koche, Richard, Leslie, Christina S.
Publicado 2021

Arid1a restrains Kras-dependent changes in acinar cell identity

por Livshits, Geulah, Alonso-Curbelo, Direna, Morris, John P, Koche, Richard, Saborowski, Michael, Wilkinson, John Erby, Lowe, Scott W
Publicado 2018

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

por Mendenhall, Eric M., Koche, Richard P., Truong, Thanh, Zhou, Vicky W., Issac, Biju, Chi, Andrew S., Ku, Manching, Bernstein, Bradley E.
Publicado 2010

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

por Ku, Manching, Jaffe, Jacob D, Koche, Richard P, Rheinbay, Esther, Endoh, Mitsuhiro, Koseki, Haruhiko, Carr, Steven A, Bernstein, Bradley E
Publicado 2012

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells

por Teijeiro, Virginia, Yang, Dapeng, Majumdar, Sonali, González, Federico, Rickert, Robert W., Xu, Chunlong, Koche, Richard, Verma, Nipun, Lai, Eric C., Huangfu, Danwei
Publicado 2018

KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis

por Sanghrajka, Reeti Mayur, Koche, Richard, Medrano, Hector, El Nagar, Salsabiel, Stephen, Daniel N., Lao, Zhimin, Bayin, N. Sumru, Ge, Kai, Joyner, Alexandra L.
Publicado 2023

MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

por Müller, Iris, Moroni, Ann Sophie, Shlyueva, Daria, Sahadevan, Sudeep, Schoof, Erwin M., Radzisheuskaya, Aliaksandra, Højfeldt, Jonas W., Tatar, Tülin, Koche, Richard P., Huang, Chang, Helin, Kristian
Publicado 2021

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

por Wolfe, Andrew L., Zhou, Qingwen, Toska, Eneda, Galeas, Jacqueline, Ku, Angel A., Koche, Richard P., Bandyopadhyay, Sourav, Scaltriti, Maurizio, Lebrilla, Carlito B., McCormick, Frank, Kim, Sung Eun
Publicado 2021

Forward genetic screen of human transposase genomic rearrangements

por Henssen, Anton G., Jiang, Eileen, Zhuang, Jiali, Pinello, Luca, Socci, Nicholas D., Koche, Richard, Gonen, Mithat, Villasante, Camila M., Armstrong, Scott A., Bauer, Daniel E., Weng, Zhiping, Kentsis, Alex
Publicado 2016

Peptidomimetic blockade of MYB in acute myeloid leukemia

por Ramaswamy, Kavitha, Forbes, Lauren, Minuesa, Gerard, Gindin, Tatyana, Brown, Fiona, Kharas, Michael G., Krivtsov, Andrei V., Armstrong, Scott A., Still, Eric, de Stanchina, Elisa, Knoechel, Birgit, Koche, Richard, Kentsis, Alex
Publicado 2018

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

por Finley, Lydia W.S., Vardhana, Santosha A., Carey, Bryce W., Alonso-Curbelo, Direna, Koche, Richard, Chen, Yanyang, Wen, Duancheng, King, Bryan, Radler, Megan R., Rafii, Shahin, Lowe, Scott W., Allis, C. David, Thompson, Craig B.
Publicado 2018

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

por Takao, Sumiko, Forbes, Lauren, Uni, Masahiro, Cheng, Shuyuan, Pineda, Jose Mario Bello, Tarumoto, Yusuke, Cifani, Paolo, Minuesa, Gerard, Chen, Celine, Kharas, Michael G, Bradley, Robert K, Vakoc, Christopher R, Koche, Richard P, Kentsis, Alex
Publicado 2021

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

por Ku, Manching, Koche, Richard P., Rheinbay, Esther, Mendenhall, Eric M., Endoh, Mitsuhiro, Mikkelsen, Tarjei S., Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S., Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M., Cowan, Chad A., Lander, Eric S., Koseki, Haruhiko, Bernstein, Bradley E.
Publicado 2008

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia

por Micol, Jean-Baptiste, Pastore, Alessandro, Inoue, Daichi, Duployez, Nicolas, Kim, Eunhee, Lee, Stanley Chun-Wei, Durham, Benjamin H., Chung, Young Rock, Cho, Hana, Zhang, Xiao Jing, Yoshimi, Akihide, Krivtsov, Andrei, Koche, Richard, Solary, Eric, Sinha, Amit, Preudhomme, Claude, Abdel-Wahab, Omar
Publicado 2017

Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer

por Mazzu, Ying Z., Liao, Yu-Rou, Nandakumar, Subhiksha, Jehane, Lina E., Koche, Richard P., Rajanala, Sai Harisha, Li, Ruifang, Zhao, HuiYong, Gerke, Travis A., Chakraborty, Goutam, Lee, Gwo-Shu Mary, Nanjangud, Gouri J., Gopalan, Anuradha, Chen, Yu, Kantoff, Philip W.
Publicado 2022

GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

por Tagore, Mohita, Hergenreder, Emiliano, Perlee, Sarah C., Cruz, Nelly M., Menocal, Laura, Suresh, Shruthy, Chan, Eric, Baron, Maayan, Melendez, Stephanie, Dave, Asim, Chatila, Walid K., Nsengimana, Jeremie, Koche, Richard P., Hollmann, Travis J., Ideker, Trey, Studer, Lorenz, Schietinger, Andrea, White, Richard M.
Publicado 2023

Mutational topography reflects clinical neuroblastoma heterogeneity

por Rodriguez-Fos, Elias, Planas-Fèlix, Mercè, Burkert, Martin, Puiggròs, Montserrat, Toedling, Joern, Thiessen, Nina, Blanc, Eric, Szymansky, Annabell, Hertwig, Falk, Ishaque, Naveed, Beule, Dieter, Torrents, David, Eggert, Angelika, Koche, Richard P., Schwarz, Roland F., Haase, Kerstin, Schulte, Johannes H., Henssen, Anton G.
Publicado 2023

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

por Chu, S. Haihua, Chabon, Jonathan R., Matovina, Chloe N., Minehart, Janna C., Chen, Bo-Ruei, Zhang, Jian, Kumar, Vipul, Xiong, Yijun, Callen, Elsa, Hung, Putzer J., Feng, Zhaohui, Koche, Richard P., Liu, X. Shirley, Chaudhuri, Jayanta, Nussenzweig, Andre, Sleckman, Barry P., Armstrong, Scott A.
Publicado 2020

Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs

por Asimomitis, Georgios, Deslauriers, André G., Kotini, Andriana G., Bernard, Elsa, Esposito, Davide, Olszewska, Malgorzata, Spyrou, Nikolaos, Arango Ossa, Juan, Mortera-Blanco, Teresa, Koche, Richard, Nannya, Yasuhito, Malcovati, Luca, Ogawa, Seishi, Cazzola, Mario, Aaronson, Stuart A., Hellström-Lindberg, Eva, Papaemmanuil, Elli, Papapetrou, Eirini P.
Publicado 2022

Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance

por Ogura, Koichi, Elkrief, Arielle, Bowman, Anita S., Koche, Richard P., de Stanchina, Elisa, Benayed, Ryma, Mauguen, Audrey, Mattar, Marissa S., Khodos, Inna, Meyers, Paul A., Healey, John H., Tap, William D., Hameed, Meera, Zehir, Ahmet, Shukla, Neerav, Sawyers, Charles, Bose, Rohit, Slotkin, Emily, Ladanyi, Marc
Publicado 2022