GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

por Mendenhall, Eric M., Koche, Richard P., Truong, Thanh, Zhou, Vicky W., Issac, Biju, Chi, Andrew S., Ku, Manching, Bernstein, Bradley E.
Publicado 2010

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

por Ku, Manching, Jaffe, Jacob D, Koche, Richard P, Rheinbay, Esther, Endoh, Mitsuhiro, Koseki, Haruhiko, Carr, Steven A, Bernstein, Bradley E
Publicado 2012

MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

por Müller, Iris, Moroni, Ann Sophie, Shlyueva, Daria, Sahadevan, Sudeep, Schoof, Erwin M., Radzisheuskaya, Aliaksandra, Højfeldt, Jonas W., Tatar, Tülin, Koche, Richard P., Huang, Chang, Helin, Kristian
Publicado 2021

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

por Wolfe, Andrew L., Zhou, Qingwen, Toska, Eneda, Galeas, Jacqueline, Ku, Angel A., Koche, Richard P., Bandyopadhyay, Sourav, Scaltriti, Maurizio, Lebrilla, Carlito B., McCormick, Frank, Kim, Sung Eun
Publicado 2021

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

por Takao, Sumiko, Forbes, Lauren, Uni, Masahiro, Cheng, Shuyuan, Pineda, Jose Mario Bello, Tarumoto, Yusuke, Cifani, Paolo, Minuesa, Gerard, Chen, Celine, Kharas, Michael G, Bradley, Robert K, Vakoc, Christopher R, Koche, Richard P, Kentsis, Alex
Publicado 2021

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

por Ku, Manching, Koche, Richard P., Rheinbay, Esther, Mendenhall, Eric M., Endoh, Mitsuhiro, Mikkelsen, Tarjei S., Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S., Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M., Cowan, Chad A., Lander, Eric S., Koseki, Haruhiko, Bernstein, Bradley E.
Publicado 2008

Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer

por Mazzu, Ying Z., Liao, Yu-Rou, Nandakumar, Subhiksha, Jehane, Lina E., Koche, Richard P., Rajanala, Sai Harisha, Li, Ruifang, Zhao, HuiYong, Gerke, Travis A., Chakraborty, Goutam, Lee, Gwo-Shu Mary, Nanjangud, Gouri J., Gopalan, Anuradha, Chen, Yu, Kantoff, Philip W.
Publicado 2022

GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

por Tagore, Mohita, Hergenreder, Emiliano, Perlee, Sarah C., Cruz, Nelly M., Menocal, Laura, Suresh, Shruthy, Chan, Eric, Baron, Maayan, Melendez, Stephanie, Dave, Asim, Chatila, Walid K., Nsengimana, Jeremie, Koche, Richard P., Hollmann, Travis J., Ideker, Trey, Studer, Lorenz, Schietinger, Andrea, White, Richard M.
Publicado 2023

Mutational topography reflects clinical neuroblastoma heterogeneity

por Rodriguez-Fos, Elias, Planas-Fèlix, Mercè, Burkert, Martin, Puiggròs, Montserrat, Toedling, Joern, Thiessen, Nina, Blanc, Eric, Szymansky, Annabell, Hertwig, Falk, Ishaque, Naveed, Beule, Dieter, Torrents, David, Eggert, Angelika, Koche, Richard P., Schwarz, Roland F., Haase, Kerstin, Schulte, Johannes H., Henssen, Anton G.
Publicado 2023

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

por Chu, S. Haihua, Chabon, Jonathan R., Matovina, Chloe N., Minehart, Janna C., Chen, Bo-Ruei, Zhang, Jian, Kumar, Vipul, Xiong, Yijun, Callen, Elsa, Hung, Putzer J., Feng, Zhaohui, Koche, Richard P., Liu, X. Shirley, Chaudhuri, Jayanta, Nussenzweig, Andre, Sleckman, Barry P., Armstrong, Scott A.
Publicado 2020

Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance

por Ogura, Koichi, Elkrief, Arielle, Bowman, Anita S., Koche, Richard P., de Stanchina, Elisa, Benayed, Ryma, Mauguen, Audrey, Mattar, Marissa S., Khodos, Inna, Meyers, Paul A., Healey, John H., Tap, William D., Hameed, Meera, Zehir, Ahmet, Shukla, Neerav, Sawyers, Charles, Bose, Rohit, Slotkin, Emily, Ladanyi, Marc
Publicado 2022

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

por Zhu, Changyu, Soto-Feliciano, Yadira M, Morris, John P, Huang, Chun-Hao, Koche, Richard P, Ho, Yu-jui, Banito, Ana, Chen, Chun-Wei, Shroff, Aditya, Tian, Sha, Livshits, Geulah, Chen, Chi-Chao, Fennell, Myles, Armstrong, Scott A, Allis, C David, Tschaharganeh, Darjus F, Lowe, Scott W
Publicado 2023

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

por Shakiba, Mojdeh, Zumbo, Paul, Espinosa-Carrasco, Gabriel, Menocal, Laura, Dündar, Friederike, Carson, Sandra E., Bruno, Emmanuel M., Sanchez-Rivera, Francisco J., Lowe, Scott W., Camara, Steven, Koche, Richard P., Reuter, Vincent P., Socci, Nicholas D., Whitlock, Benjamin, Tamzalit, Fella, Huse, Morgan, Hellmann, Matthew D., Wells, Daniel K., Defranoux, Nadine A., Betel, Doron, Philip, Mary, Schietinger, Andrea
Publicado 2021

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

por Chamorro González, Rocío, Conrad, Thomas, Stöber, Maja C., Xu, Robin, Giurgiu, Mădălina, Rodriguez-Fos, Elias, Kasack, Katharina, Brückner, Lotte, van Leen, Eric, Helmsauer, Konstantin, Dorado Garcia, Heathcliff, Stefanova, Maria E., Hung, King L., Bei, Yi, Schmelz, Karin, Lodrini, Marco, Mundlos, Stefan, Chang, Howard Y., Deubzer, Hedwig E., Sauer, Sascha, Eggert, Angelika, Schulte, Johannes H., Schwarz, Roland F., Haase, Kerstin, Koche, Richard P., Henssen, Anton G.
Publicado 2023

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses

por Yan, Juan, Chen, Yuedan, Patel, Amish J., Warda, Sarah, Lee, Cindy J., Nixon, Briana G., Wong, Elissa W.P., Miranda-Román, Miguel A., Yang, Ning, Wang, Yi, Pachai, Mohini R., Sher, Jessica, Giff, Emily, Tang, Fanying, Khurana, Ekta, Singer, Sam, Liu, Yang, Galbo, Phillip M., Maag, Jesper L.V., Koche, Richard P., Zheng, Deyou, Antonescu, Cristina R., Deng, Liang, Li, Ming O., Chen, Yu, Chi, Ping
Publicado 2022

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

por Helmsauer, Konstantin, Valieva, Maria E., Ali, Salaheddine, Chamorro González, Rocío, Schöpflin, Robert, Röefzaad, Claudia, Bei, Yi, Dorado Garcia, Heathcliff, Rodriguez-Fos, Elias, Puiggròs, Montserrat, Kasack, Katharina, Haase, Kerstin, Keskeny, Csilla, Chen, Celine Y., Kuschel, Luis P., Euskirchen, Philipp, Heinrich, Verena, Robson, Michael I., Rosswog, Carolina, Toedling, Joern, Szymansky, Annabell, Hertwig, Falk, Fischer, Matthias, Torrents, David, Eggert, Angelika, Schulte, Johannes H., Mundlos, Stefan, Henssen, Anton G., Koche, Richard P.
Publicado 2020

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry

por Patel, Amish J., Warda, Sarah, Maag, Jesper L.V., Misra, Rohan, Miranda-Román, Miguel A., Pachai, Mohini R., Lee, Cindy J., Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W.P., Yan, Juan, Giff, Emily, Pappalardi, Melissa B., McCabe, Michael T., Fletcher, Jonathan A., Rudin, Charles M., Chandarlapaty, Sarat, Scandura, Joseph M., Koche, Richard P., Glass, Jacob L., Antonescu, Cristina R., Zheng, Deyou, Chen, Yu, Chi, Ping
Publicado 2022

Epigenetic dysregulation from chromosomal transit in micronuclei

por Agustinus, Albert S., Al-Rawi, Duaa, Dameracharla, Bhargavi, Raviram, Ramya, Jones, Bailey S. C. L., Stransky, Stephanie, Scipioni, Lorenzo, Luebeck, Jens, Di Bona, Melody, Norkunaite, Danguole, Myers, Robert M., Duran, Mercedes, Choi, Seongmin, Weigelt, Britta, Yomtoubian, Shira, McPherson, Andrew, Toufektchan, Eléonore, Keuper, Kristina, Mischel, Paul S., Mittal, Vivek, Shah, Sohrab P., Maciejowski, John, Storchova, Zuzana, Gratton, Enrico, Ly, Peter, Landau, Dan, Bakhoum, Mathieu F., Koche, Richard P., Sidoli, Simone, Bafna, Vineet, David, Yael, Bakhoum, Samuel F.
Publicado 2023

Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation

por Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Ray-Kirton, Jordana, Egger, Jacklynn D., Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Roehrl, Michael H., Ventura, Katia, Qiu, Juan, de Stanchina, Elisa, Chang, Jason C., Rekhtman, Natasha, Houck-Loomis, Brian, Koche, Richard P., Yu, Helena A., Sen, Triparna, Rudin, Charles M.
Publicado 2021