Manipulation of autophagy by SARS-CoV-2 proteins

por Koepke, Lennart, Hirschenberger, Maximilian, Hayn, Manuel, Kirchhoff, Frank, Sparrer, Konstantin MJ
Publicado 2021

Interferon antagonists encoded by SARS-CoV-2 at a glance

por Lee, Jung-Hyun, Koepke, Lennart, Kirchhoff, Frank, Sparrer, Konstantin M. J.
Publicado 2022

Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins

por Hirschenberger, Maximilian, Hayn, Manuel, Laliberté, Alexandre, Koepke, Lennart, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes
Publicado 2021

Head-to-head comparison of different classes of FAP radioligands designed to increase tumor residence time: monomer, dimer, albumin binders, and small molecules vs peptides

por Millul, Jacopo, Koepke, Lennart, Haridas, Gaonkar Raghuvir, Sparrer, Konstantin M. J., Mansi, Rosalba, Fani, Melpomeni
Publicado 2023

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

por Jung, Christoph, Kmiec, Dorota, Koepke, Lennart, Zech, Fabian, Jacob, Timo, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2022

HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression

por Srinivasachar Badarinarayan, Smitha, Shcherbakova, Irina, Langer, Simon, Koepke, Lennart, Preising, Andrea, Hotter, Dominik, Kirchhoff, Frank, Sparrer, Konstantin M J, Schotta, Gunnar, Sauter, Daniel
Publicado 2020

An improved method for high-throughput quantification of autophagy in mammalian cells

por Koepke, Lennart, Winter, Benjamin, Grenzner, Alexander, Regensburger, Kerstin, Engelhart, Susanne, van der Merwe, Johannes A., Krebs, Stefan, Blum, Helmut, Kirchhoff, Frank, Sparrer, Konstantin M. J.
Publicado 2020

SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells

por Nchioua, Rayhane, Schundner, Annika, Kmiec, Dorota, Prelli Bozzo, Caterina, Zech, Fabian, Koepke, Lennart, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Frick, Manfred, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2022

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids

por Krüger, Jana, Groß, Rüdiger, Conzelmann, Carina, Müller, Janis A., Koepke, Lennart, Sparrer, Konstantin M.J., Weil, Tatjana, Schütz, Desiree, Seufferlein, Thomas, Barth, Thomas F.E., Stenger, Steffen, Heller, Sandra, Münch, Jan, Kleger, Alexander
Publicado 2020

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

por Nchioua, Rayhane, Schundner, Annika, Klute, Susanne, Koepke, Lennart, Hirschenberger, Maximilian, Noettger, Sabrina, Fois, Giorgio, Zech, Fabian, Graf, Alexander, Krebs, Stefan, Braubach, Peter, Blum, Helmut, Stenger, Steffen, Kmiec, Dorota, Frick, Manfred, Kirchhoff, Frank, Sparrer, Konstantin MJ
Publicado 2023

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

por Thoms, Matthias, Buschauer, Robert, Ameismeier, Michael, Koepke, Lennart, Denk, Timo, Hirschenberger, Maximilian, Kratzat, Hanna, Hayn, Manuel, Mackens-Kiani, Timur, Cheng, Jingdong, Straub, Jan H., Stürzel, Christina M., Fröhlich, Thomas, Berninghausen, Otto, Becker, Thomas, Kirchhoff, Frank, Sparrer, Konstantin M. J., Beckmann, Roland
Publicado 2020

Spike residue 403 affects binding of coronavirus spikes to human ACE2

por Zech, Fabian, Schniertshauer, Daniel, Jung, Christoph, Herrmann, Alexandra, Cordsmeier, Arne, Xie, Qinya, Nchioua, Rayhane, Prelli Bozzo, Caterina, Volcic, Meta, Koepke, Lennart, Müller, Janis A., Krüger, Jana, Heller, Sandra, Stenger, Steffen, Hoffmann, Markus, Pöhlmann, Stefan, Kleger, Alexander, Jacob, Timo, Conzelmann, Karl-Klaus, Ensser, Armin, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2021

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

por Hayn, Manuel, Hirschenberger, Maximilian, Koepke, Lennart, Nchioua, Rayhane, Straub, Jan Hendrik, Klute, Susanne, Hunszinger, Victoria, Zech, Fabian, Prelli Bozzo, Caterina, Aftab, Wasim, Christensen, Maria Hønholt, Conzelmann, Carina, Müller, Janis Alexander, Srinivasachar Badarinarayan, Smitha, Stürzel, Christina Martina, Forne, Ignasi, Stenger, Steffen, Conzelmann, Karl-Klaus, Münch, Jan, Schmidt, Florian Ingo, Sauter, Daniel, Imhof, Axel, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes
Publicado 2021

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

por Hirschenberger, Maximilian, Lepelley, Alice, Rupp, Ulrich, Klute, Susanne, Hunszinger, Victoria, Koepke, Lennart, Merold, Veronika, Didry-Barca, Blaise, Wondany, Fanny, Bergner, Tim, Moreau, Tatiana, Rodero, Mathieu P., Rösler, Reinhild, Wiese, Sebastian, Volpi, Stefano, Gattorno, Marco, Papa, Riccardo, Lynch, Sally-Ann, Haug, Marte G., Houge, Gunnar, Wigby, Kristen M., Sprague, Jessica, Lenberg, Jerica, Read, Clarissa, Walther, Paul, Michaelis, Jens, Kirchhoff, Frank, de Oliveira Mann, Carina C., Crow, Yanick J., Sparrer, Konstantin M. J.
Publicado 2023

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

por Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2021