HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development

por Hack, Stephen P., Bruey, Jean-Marie, Koeppen, Hartmut
Publicado 2014

Microenvironmental regulation of tumour immunity and response to immunotherapy

por Kockx, Mark M, McCleland, Mark, Koeppen, Hartmut
Publicado 2021

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation

por Chen, Tom T., Filvaroff, Ellen, Peng, Jing, Marsters, Scot, Jubb, Adrian, Koeppen, Hartmut, Merchant, Mark, Ashkenazi, Avi
Publicado 2015

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

por Ingle, Gladys S, Chan, Pamela, Elliott, J Michael, Chang, Wesley S, Koeppen, Hartmut, Stephan, Jean-Philippe, Scales, Suzie J
Publicado 2008

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

por Wick, Maresa, Dubey, Purnima, Koeppen, Hartmut, Siegel, Christopher T., Fields, Patrick E., Chen, Lieping, Bluestone, Jeffrey A., Schreiber, Hans
Publicado 1997

High cell-surface density of HER2 deforms cell membranes

por Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.
Publicado 2016

p21-activated kinase 1: PAK'ed with potential

por Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Publicado 2011

Intratumoral characteristics of tumor and immune cells at baseline and on-treatment correlated with clinical responses to MPDL3280A, an engineered antibody against PD-L1

por Kohrt, Holbrook, Kowanetz, Marcin, Gettinger, Scott, Powderly, John, Koeppen, Hartmut, Sosman, Jeffrey A, Cruz, Cristina, Xiao, Yuanyuan, Mokatrin, Ahmad, Fine, Gregg, Chen, Daniel S, Hodi, F Stephen
Publicado 2013

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

por Viotti, Manuel, Wilson, Catherine, McCleland, Mark, Koeppen, Hartmut, Haley, Benjamin, Jhunjhunwala, Suchit, Klijn, Christiaan, Modrusan, Zora, Arnott, David, Classon, Marie, Stephan, Jean-Philippe, Mellman, Ira
Publicado 2018

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

por Lin, Kui, Taylor, James R., Wu, Thomas D., Gutierrez, Johnny, Elliott, J. Michael, Vernes, Jean-Michel, Koeppen, Hartmut, Phillips, Heidi S., de Sauvage, Frederic J., Meng, Y. Gloria
Publicado 2011

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas

por Schmitz, Katja, Koeppen, Hartmut, Binot, Elke, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela A., Heydt, Carina, Wardelmann, Eva, Büttner, Reinhard, Merkelbach-Bruse, Sabine, Rüschoff, Josef, Schildhaus, Hans-Ulrich
Publicado 2015

Targeted Biomarker Profiling of Matched Primary and Metastatic Estrogen Receptor Positive Breast Cancers

por Schleifman, Erica B., Desai, Rupal, Spoerke, Jill M., Xiao, Yuanyuan, Wong, Cheryl, Abbas, Ilma, O’Brien, Carol, Patel, Rajesh, Sumiyoshi, Teiko, Fu, Ling, Tam, Rachel N., Koeppen, Hartmut, Wilson, Timothy R., Raja, Rajiv, Hampton, Garret M., Lackner, Mark R.
Publicado 2014

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

por Le Thomas, Adrien, Ferri, Elena, Marsters, Scot, Harnoss, Jonathan M., Lawrence, David A., Zuazo-Gaztelu, Iratxe, Modrusan, Zora, Chan, Sara, Solon, Margaret, Chalouni, Cécile, Li, Weihan, Koeppen, Hartmut, Rudolph, Joachim, Wang, Weiru, Wu, Thomas D., Walter, Peter, Ashkenazi, Avi
Publicado 2021

Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples

por Wilson, Timothy R., Xiao, Yuanyuan, Spoerke, Jill M., Fridlyand, Jane, Koeppen, Hartmut, Fuentes, Eloisa, Huw, Ling Y., Abbas, Ilma, Gower, Arjan, Schleifman, Erica B., Desai, Rupal, Fu, Ling, Sumiyoshi, Teiko, O’Shaughnessy, Joyce A., Hampton, Garret M., Lackner, Mark R.
Publicado 2014

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

por Desbois, Mélanie, Udyavar, Akshata R., Ryner, Lisa, Kozlowski, Cleopatra, Guan, Yinghui, Dürrbaum, Milena, Lu, Shan, Fortin, Jean-Philippe, Koeppen, Hartmut, Ziai, James, Chang, Ching-Wei, Keerthivasan, Shilpa, Plante, Marie, Bourgon, Richard, Bais, Carlos, Hegde, Priti, Daemen, Anneleen, Turley, Shannon, Wang, Yulei
Publicado 2020

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

por Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike
Publicado 2017

Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab

por Vennapusa, Bharathi, Baker, Brian, Kowanetz, Marcin, Boone, Jennifer, Menzl, Ina, Bruey, Jean-Marie, Fine, Gregg, Mariathasan, Sanjeev, McCaffery, Ian, Mocci, Simonetta, Rost, Sandra, Smith, Dustin, Dennis, Eslie, Tang, Szu-Yu, Damadzadeh, Bita, Walker, Espen, Hegde, Priti S., Williams, J. Andrew, Koeppen, Hartmut, Boyd, Zachary
Publicado 2019

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

por Wallin, Jeffrey J., Bendell, Johanna C., Funke, Roel, Sznol, Mario, Korski, Konstanty, Jones, Suzanne, Hernandez, Genevive, Mier, James, He, Xian, Hodi, F. Stephen, Denker, Mitchell, Leveque, Vincent, Cañamero, Marta, Babitski, Galina, Koeppen, Hartmut, Ziai, James, Sharma, Neeraj, Gaire, Fabien, Chen, Daniel S., Waterkamp, Daniel, Hegde, Priti S., McDermott, David F.
Publicado 2016

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

por Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, de Sauvage, Frederic J.
Publicado 2022

Circulating and tumor-based biomarkers predict clinical activity in cancer patients treated with the engineered anti-PD-L1 antibody MPDL3280A

por Kowanetz, Marcin, Rabe, Christina, Xiao, Yuanyuan, Wu, Qun J, Koeppen, Hartmut, Leddy, Cecilia, Patel, Rajesh D, Powderly, John, Kohrt, Holbrook, Gettinger, Scott, Soria, Jean-Charles, Herbst, Roy S, Desai, Rupal, Denker, Mitchell, Ruppel, Jane, Boe, Marigold, Nakamura, Rin, Fu, Ling, Sumiyoshi, Teiko, Mokatrin, Ahmad, Shen, Xiaodong, Fine, Gregg, Chen, Daniel S, Hegde, Priti S
Publicado 2014