Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.

por Kovatcheva, Marta, Klein, Mary E., Tap, William D., Koff, Andrew
Publicado 2017

Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas

por See, Wendy L., Miller, Jeffrey P., Squatrito, Massimo, Holland, Eric, Resh, Marilyn D., Koff, Andrew
Publicado 2010

A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma

por Langthaler, Sonja, Rienmüller, Theresa, Scheruebel, Susanne, Pelzmann, Brigitte, Shrestha, Niroj, Zorn-Pauly, Klaus, Schreibmayer, Wolfgang, Koff, Andrew, Baumgartner, Christian
Publicado 2021

Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)

por Liu, Yuhui, Yeh, Nancy, Zhu, Xin-Hua, Leversha, Margaret, Cordon-Cardo, Carlos, Ghossein, Ronald, Singh, Bhuvanesh, Holland, Eric, Koff, Andrew
Publicado 2007

ATRX is a regulator of therapy induced senescence in human cells

por Kovatcheva, Marta, Liao, Will, Klein, Mary E., Robine, Nicolas, Geiger, Heather, Crago, Aimee M., Dickson, Mark A., Tap, William D., Singer, Samuel, Koff, Andrew
Publicado 2017

TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)

por Liu, Yuhui, Raheja, Radhika, Yeh, Nancy, Ciznadija, Daniel, Pedraza, Alicia M., Ozawa, Tatsuya, Hukkelhoven, Ellen, Erdjument-Bromage, Hediye, Tempst, Paul, Gauthier, Nicholas Paul, Brennan, Cameron, Holland, Eric C., Koff, Andrew
Publicado 2013

PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence

por Klein, Mary E., Dickson, Mark A., Antonescu, Cristina, Qin, Li-Xuan, Dooley, Scott J., Barlas, Afsar, Manova, Katia, Schwartz, Gary K., Crago, Aimee M., Singer, Samuel, Koff, Andrew, Tap, William D.
Publicado 2018

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

por Kovatcheva, Marta, Liu, David D., Dickson, Mark A., Klein, Mary E., O'Connor, Rachael, Wilder, Fatima O., Socci, Nicholas D., Tap, William D., Schwartz, Gary K., Singer, Samuel, Crago, Aimee M., Koff, Andrew
Publicado 2015

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

por Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S., Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S., Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Donovan, Katherine A., Palafox, Marta, Reis-Filho, Jorge S., de Stanchina, Elisa, Fischer, Eric S., Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D., Gray, Nathanael S., Chandarlapaty, Sarat
Publicado 2022

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

por D’Angelo, Sandra P., Richards, Allison L., Conley, Anthony P., Woo, Hyung Jun, Dickson, Mark A., Gounder, Mrinal, Kelly, Ciara, Keohan, Mary Louise, Movva, Sujana, Thornton, Katherine, Rosenbaum, Evan, Chi, Ping, Nacev, Benjamin, Chan, Jason E., Slotkin, Emily K., Kiesler, Hannah, Adamson, Travis, Ling, Lilan, Rao, Pavitra, Patel, Shreyaskumar, Livingston, Jonathan A., Singer, Samuel, Agaram, Narasimhan P., Antonescu, Cristina R., Koff, Andrew, Erinjeri, Joseph P., Hwang, Sinchun, Qin, Li-Xuan, Donoghue, Mark T. A., Tap, William D.
Publicado 2022