Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2

por Takagi, Satoshi, Sato, Shigeo, Oh-hara, Tomoko, Takami, Miho, Koike, Sumie, Mishima, Yuji, Hatake, Kiyohiko, Fujita, Naoya
Publicado 2013

Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer

por Sakashita, Takuya, Yanagitani, Noriko, Koike, Sumie, Low, Siew‐Kee, Takagi, Satoshi, Baba, Satoko, Takeuchi, Kengo, Nishio, Makoto, Fujita, Naoya, Katayama, Ryohei
Publicado 2022

GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer

por Shimizu, Yuki, Okada, Koutaroh, Adachi, Jun, Abe, Yuichi, Narumi, Ryohei, Uchibori, Ken, Yanagitani, Noriko, Koike, Sumie, Takagi, Satoshi, Nishio, Makoto, Fujita, Naoya, Katayama, Ryohei
Publicado 2022

Drug resistance mechanisms in Japanese anaplastic lymphoma kinase‐positive non–small cell lung cancer and the clinical responses based on the resistant mechanisms

por Yanagitani, Noriko, Uchibori, Ken, Koike, Sumie, Tsukahara, Mika, Kitazono, Satoru, Yoshizawa, Takahiro, Horiike, Atsushi, Ohyanagi, Fumiyoshi, Tambo, Yuichi, Nishikawa, Shingo, Fujita, Naoya, Katayama, Ryohei, Nishio, Makoto
Publicado 2020

Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

por Takagi, Satoshi, Sasaki, Yuki, Koike, Sumie, Takemoto, Ai, Seto, Yosuke, Haraguchi, Mizuki, Ukaji, Takao, Kawaguchi, Tokuichi, Sugawara, Minoru, Saito, Masanori, Funauchi, Yuki, Ae, Keisuke, Matsumoto, Seiichi, Fujita, Naoya, Katayama, Ryohei
Publicado 2021

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance

por Okada, Koutaroh, Araki, Mitsugu, Sakashita, Takuya, Ma, Biao, Kanada, Ryo, Yanagitani, Noriko, Horiike, Atsushi, Koike, Sumie, Oh-hara, Tomoko, Watanabe, Kana, Tamai, Keiichi, Maemondo, Makoto, Nishio, Makoto, Ishikawa, Takeshi, Okuno, Yasushi, Fujita, Naoya, Katayama, Ryohei
Publicado 2019

Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity

por Yoshizawa, Takahiro, Uchibori, Ken, Araki, Mitsugu, Matsumoto, Shigeyuki, Ma, Biao, Kanada, Ryo, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Ariyasu, Ryo, Kitazono, Satoru, Ninomiya, Hironori, Takeuchi, Kengo, Yanagitani, Noriko, Takagi, Satoshi, Kishi, Kazuma, Fujita, Naoya, Okuno, Yasushi, Nishio, Makoto, Katayama, Ryohei
Publicado 2021

P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer

por Katayama, Ryohei, Sakashita, Takuya, Yanagitani, Noriko, Ninomiya, Hironori, Horiike, Atsushi, Friboulet, Luc, Gainor, Justin F., Motoi, Noriko, Dobashi, Akito, Sakata, Seiji, Tambo, Yuichi, Kitazono, Satoru, Sato, Shigeo, Koike, Sumie, John Iafrate, A., Mino-Kenudson, Mari, Ishikawa, Yuichi, Shaw, Alice T., Engelman, Jeffrey A., Takeuchi, Kengo, Nishio, Makoto, Fujita, Naoya
Publicado 2015

The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models

por Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N., Shaw, Alice T., Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi
Publicado 2019