Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study

por Koivumäki, Jussi T., Korhonen, Topi, Tavi, Pasi
Publicado 2011

A mathematical model of hiPSC cardiomyocytes electromechanics

por Forouzandehmehr, Mohamadamin, Koivumäki, Jussi T., Hyttinen, Jari, Paci, Michelangelo
Publicado 2021

Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights

por Forouzandehmehr, Mohamadamin, Paci, Michelangelo, Koivumäki, Jussi T, Hyttinen, Jari
Publicado 2022

In Silico Screening of the Key Cellular Remodeling Targets in Chronic Atrial Fibrillation

por Koivumäki, Jussi T., Seemann, Gunnar, Maleckar, Mary M., Tavi, Pasi
Publicado 2014

Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling

por Koivumäki, Jussi T, Korhonen, Topi, Takalo, Jouni, Weckström, Matti, Tavi, Pasi
Publicado 2009

Sex differences in heart: from basics to clinics

por Prajapati, Chandra, Koivumäki, Jussi, Pekkanen-Mattila, Mari, Aalto-Setälä, Katriina
Publicado 2022

Benchmarking electrophysiological models of human atrial myocytes

por Wilhelms, Mathias, Hettmann, Hanne, Maleckar, Mary M., Koivumäki, Jussi T., Dössel, Olaf, Seemann, Gunnar
Publicado 2013

Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

por Paci, Michelangelo, Koivumäki, Jussi T., Lu, Hua Rong, Gallacher, David J., Passini, Elisa, Rodriguez, Blanca
Publicado 2021

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective

por Ismaili, Djemail, Schulz, Carl, Horváth, András, Koivumäki, Jussi T., Mika, Delphine, Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Publicado 2023

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

por Vuorenpää, Hanna, Björninen, Miina, Välimäki, Hannu, Ahola, Antti, Kroon, Mart, Honkamäki, Laura, Koivumäki, Jussi T., Pekkanen-Mattila, Mari
Publicado 2023

Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

por Vagos, Márcia, van Herck, Ilsbeth G. M., Sundnes, Joakim, Arevalo, Hermenegild J., Edwards, Andrew G., Koivumäki, Jussi T.
Publicado 2018

hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells

por Shah, Disheet, Prajapati, Chandra, Penttinen, Kirsi, Cherian, Reeja Maria, Koivumäki, Jussi T., Alexanova, Anna, Hyttinen, Jari, Aalto-Setälä, Katriina
Publicado 2020

Na(+) current expression in human atrial myofibroblasts: identity and functional roles

por Koivumäki, Jussi T., Clark, Robert B., Belke, Darrell, Kondo, Colleen, Fedak, Paul W. M., Maleckar, Mary M. C., Giles, Wayne R.
Publicado 2014

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart

por Naumenko, Nikolay, Huusko, Jenni, Tuomainen, Tomi, Koivumäki, Jussi T., Merentie, Mari, Gurzeler, Erika, Alitalo, Kari, Kivelä, Riikka, Ylä-Herttuala, Seppo, Tavi, Pasi
Publicado 2017

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

por Koivumäki, Jussi T., Naumenko, Nikolay, Tuomainen, Tomi, Takalo, Jouni, Oksanen, Minna, Puttonen, Katja A., Lehtonen, Šárka, Kuusisto, Johanna, Laakso, Markku, Koistinaho, Jari, Tavi, Pasi
Publicado 2018

Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (I(bk,Ca))

por Horváth, András, Christ, Torsten, Koivumäki, Jussi T., Prondzynski, Maksymilian, Zech, Antonia T. L., Spohn, Michael, Saleem, Umber, Mannhardt, Ingra, Ulmer, Bärbel, Girdauskas, Evaldas, Meyer, Christian, Hansen, Arne, Eschenhagen, Thomas, Lemoine, Marc D.
Publicado 2020

Regulation of APD and Force by the Na(+)/Ca(2+) Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue

por Ismaili, Djemail, Gurr, Katrin, Horváth, András, Yuan, Lei, Lemoine, Marc D., Schulz, Carl, Sani, Jascha, Petersen, Johannes, Reichenspurner, Hermann, Kirchhof, Paulus, Jespersen, Thomas, Eschenhagen, Thomas, Hansen, Arne, Koivumäki, Jussi T., Christ, Torsten
Publicado 2022

Translational investigation of electrophysiology in hypertrophic cardiomyopathy

por Flenner, Frederik, Jungen, Christiane, Küpker, Nadine, Ibel, Antonia, Kruse, Martin, Koivumäki, Jussi T., Rinas, Anna, Zech, Antonia T.L., Rhoden, Alexandra, Wijnker, Paul J.M., Lemoine, Marc D., Steenpass, Anna, Girdauskas, Evaldas, Eschenhagen, Thomas, Meyer, Christian, van der Velden, Jolanda, Patten-Hamel, Monica, Christ, Torsten, Carrier, Lucie
Publicado 2021

Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy

por Prondzynski, Maksymilian, Lemoine, Marc D, Zech, Antonia TL, Horváth, András, Di Mauro, Vittoria, Koivumäki, Jussi T, Kresin, Nico, Busch, Josefine, Krause, Tobias, Krämer, Elisabeth, Schlossarek, Saskia, Spohn, Michael, Friedrich, Felix W, Münch, Julia, Laufer, Sandra D, Redwood, Charles, Volk, Alexander E, Hansen, Arne, Mearini, Giulia, Catalucci, Daniele, Meyer, Christian, Christ, Torsten, Patten, Monica, Eschenhagen, Thomas, Carrier, Lucie
Publicado 2019