Combining targeted drugs to overcome and prevent resistance of solid cancers with some stem-like cell features

por Jokinen, Elina, Laurila, Niina, Koivunen, Peppi, Koivunen, Jussi P.
Publicado 2014

Higher hemoglobin levels are an independent risk factor for gestational diabetes

por Sissala, Niina, Mustaniemi, Sanna, Kajantie, Eero, Vääräsmäki, Marja, Koivunen, Peppi
Publicado 2022

Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

por Tapio, Joona, Vähänikkilä, Hannu, Kesäniemi, Y. Antero, Ukkola, Olavi, Koivunen, Peppi
Publicado 2021

The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer

por Peurala, Emmi, Koivunen, Peppi, Haapasaari, Kirsi-Maria, Bloigu, Risto, Jukkola-Vuorinen, Arja
Publicado 2013

Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

por Määttä, Jenni, Sissala, Niina, Dimova, Elitsa Y., Serpi, Raisa, Moore, Lorna G., Koivunen, Peppi
Publicado 2018

Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

por Määttä, Jenni, Sissala, Niina, Dimova, Elitsa Y., Serpi, Raisa, Moore, Lorna G., Koivunen, Peppi
Publicado 2020

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium

por Dengler, Franziska, Sova, Sofia, Salo, Antti M., Mäki, Joni M., Koivunen, Peppi, Myllyharju, Johanna
Publicado 2021

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

por Koivunen, Peppi, Fell, Stuart M, Lu, Wenyun, Rabinowitz, Joshua D, Kung, Andrew L, Schlisio, Susanne
Publicado 2016

Hypoxia ameliorates maternal diet‐induced insulin resistance during pregnancy while having a detrimental effect on the placenta

por Sissala, Niina, Myllymäki, Elisa, Mohr, Florian, Halmetoja, Riikka, Kuvaja, Paula, Dimova, Elitsa Y., Koivunen, Peppi
Publicado 2022

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice

por Settelmeier, Stephan, Schreiber, Timm, Mäki, Joni, Byts, Nadiya, Koivunen, Peppi, Myllyharju, Johanna, Fandrey, Joachim, Winning, Sandra
Publicado 2020

Activation of the hypoxia response protects mice from amyloid-β accumulation

por Ollonen, Teemu, Kurkela, Margareta, Laitakari, Anna, Sakko, Samuli, Koivisto, Henna, Myllyharju, Johanna, Tanila, Heikki, Serpi, Raisa, Koivunen, Peppi
Publicado 2022

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains

por Myllykoski, Matti, Sutinen, Aleksi, Koski, M. Kristian, Kallio, Juha P., Raasakka, Arne, Myllyharju, Johanna, Wierenga, Rik K., Koivunen, Peppi
Publicado 2020

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism

por Tapio, Joona, Halmetoja, Riikka, Dimova, Elitsa Y., Mäki, Joni M., Laitala, Anu, Walkinshaw, Gail, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi
Publicado 2022

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes

por Byts, Nadiya, Sharma, Subodh, Laurila, Jenny, Paudel, Prodeep, Miinalainen, Ilkka, Ronkainen, Veli-Pekka, Hinttala, Reetta, Törnquist, Kid, Koivunen, Peppi, Myllyharju, Johanna
Publicado 2021

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

por Ratcliffe, Peter, Koivunen, Peppi, Myllyharju, Johanna, Ragoussis, Jiannis, Bovée, Judith VMG, Batinic-Haberle, Ines, Vinatier, Claire, Trichet, Valérie, Robriquet, Florence, Oliver, Lisa, Gardie, Betty
Publicado 2017

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease

por Laitakari, Anna, Ollonen, Teemu, Kietzmann, Thomas, Walkinshaw, Gail, Mennerich, Daniela, Izzi, Valerio, Haapasaari, Kirsi-Maria, Myllyharju, Johanna, Serpi, Raisa, Dimova, Elitsa Y., Koivunen, Peppi
Publicado 2019

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

por Byts, Nadiya, Sharma, Subodh, Malm, Tarja, Kaakinen, Mika, Korhonen, Paula, Jaakkonen, Laura, Keuters, Meike, Huuskonen, Mikko, Pietilä, Ilkka, Koistinaho, Jari, Koivunen, Peppi, Myllyharju, Johanna
Publicado 2022

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD

por Laitakari, Anna, Tapio, Joona, Mäkelä, Kari A., Herzig, Karl-Heinz, Dengler, Franziska, Gylling, Helena, Walkinshaw, Gail, Myllyharju, Johanna, Dimova, Elitsa Y., Serpi, Raisa, Koivunen, Peppi
Publicado 2020

Structural basis of homo- and heterotrimerization of collagen I

por Sharma, Urvashi, Carrique, Loïc, Vadon-Le Goff, Sandrine, Mariano, Natacha, Georges, Rainier-Numa, Delolme, Frederic, Koivunen, Peppi, Myllyharju, Johanna, Moali, Catherine, Aghajari, Nushin, Hulmes, David J. S.
Publicado 2017

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

por D’Hulst, Gommaar, Soro-Arnaiz, Inés, Masschelein, Evi, Veys, Koen, Fitzgerald, Gillian, Smeuninx, Benoit, Kim, Sunghoon, Deldicque, Louise, Blaauw, Bert, Carmeliet, Peter, Breen, Leigh, Koivunen, Peppi, Zhao, Shi-Min, De Bock, Katrien
Publicado 2020