Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases

por Okumura, Naoki, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2017

Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy

por Okumura, Naoki, Hayashi, Ryousuke, Koizumi, Noriko
Publicado 2018

Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study

por Nakagawa, Hiroko, Koizumi, Noriko, Okumura, Naoki, Suganami, Hideki, Kinoshita, Shigeru
Publicado 2015

Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9

por Higashioka, Koki, Koizumi, Noriko, Sakurai, Hidetoshi, Sotozono, Chie, Sato, Takahiko
Publicado 2017

Development of Poly Lactic/Glycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor

por Koda, Sho, Okumura, Naoki, Kitano, Junji, Koizumi, Noriko, Tabata, Yasuhiko
Publicado 2017

Feasibility of a cryopreservation of cultured human corneal endothelial cells

por Okumura, Naoki, Kagami, Takato, Watanabe, Kyoko, Kadoya, Saori, Sato, Masakazu, Koizumi, Noriko
Publicado 2019

Inhibition of TGF-β Signaling Enables Human Corneal Endothelial Cell Expansion In Vitro for Use in Regenerative Medicine

por Okumura, Naoki, Kay, EunDuck P., Nakahara, Makiko, Hamuro, Junji, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2013

Transcriptome dataset of human corneal endothelium based on ribosomal RNA-depleted RNA-Seq data

por Tokuda, Yuichi, Okumura, Naoki, Komori, Yuya, Hanada, Naoya, Tashiro, Kei, Koizumi, Noriko, Nakano, Masakazu
Publicado 2020

Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells

por Okumura, Naoki, Kusakabe, Ayaka, Hirano, Hiroatsu, Inoue, Ryota, Okazaki, Yugo, Nakano, Shinichiro, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2015

Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells

por Polisetti, Naresh, Sorokin, Lydia, Okumura, Naoki, Koizumi, Noriko, Kinoshita, Shigeru, Kruse, Friedrich E., Schlötzer-Schrehardt, Ursula
Publicado 2017

Crossover Randomized Study of Pharmacologic Effects of Ripasudil–Brimonidine Fixed-Dose Combination Versus Ripasudil or Brimonidine

por Tanihara, Hidenobu, Yamamoto, Tetsuya, Aihara, Makoto, Koizumi, Noriko, Minami, Hiroomi, Kojima, Satoshi, Isobe, Tomoyuki, Kanazawa, Mizuho, Suganami, Hideki
Publicado 2023

A selective inhibitor of the Rho kinase pathway, Y-27632, and its influence on wound healing in the corneal stroma

por Yamamoto, Mayumi, Quantock, Andrew J., Young, Robert D., Okumura, Naoki, Ueno, Morio, Sakamoto, Yuji, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2012

Corneal Endothelial Expansion Promoted by Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium

por Nakahara, Makiko, Okumura, Naoki, Kay, EunDuck P., Hagiya, Michio, Imagawa, Kiwamu, Hosoda, Yuuki, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2013

Cultivation of Corneal Endothelial Cells on a Pericellular Matrix Prepared from Human Decidua-Derived Mesenchymal Cells

por Numata, Ryohei, Okumura, Naoki, Nakahara, Makiko, Ueno, Morio, Kinoshita, Shigeru, Kanematsu, Daisuke, Kanemura, Yonehiro, Sasai, Yoshiki, Koizumi, Noriko
Publicado 2014

Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction

por Okumura, Naoki, Kakutani, Kazuya, Inoue, Ryota, Matsumoto, Daiki, Shimada, Tomoki, Nakahara, Makiko, Kiyanagi, Yumiko, Itoh, Takehiro, Koizumi, Noriko
Publicado 2016

Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity

por Sotozono, Chie, Inatomi, Tsutomu, Nakamura, Takahiro, Koizumi, Noriko, Yokoi, Norihiko, Ueta, Mayumi, Matsuyama, Kotone, Kaneda, Hideaki, Fukushima, Masanori, Kinoshita, Shigeru
Publicado 2014

RNA-Seq–based transcriptome analysis of corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy

por Nakagawa, Tatsuya, Tokuda, Yuichi, Nakano, Masakazu, Komori, Yuya, Hanada, Naoya, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Tashiro, Kei, Koizumi, Noriko, Okumura, Naoki
Publicado 2023

Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model

por Okumura, Naoki, Matsumoto, Daiki, Fukui, Yuya, Teramoto, Masataka, Imai, Hirofumi, Kurosawa, Tetta, Shimada, Tomoki, Kruse, Friedrich, Schlötzer-Schrehardt, Ursula, Kinoshita, Shigeru, Koizumi, Noriko
Publicado 2018

Shotgun proteomics identification of proteins expressed in the Descemet’s membrane of patients with Fuchs endothelial corneal dystrophy

por Nakagawa, Tatsuya, Okumura, Naoki, Ikegawa, Masaya, Toyama, Yumiko, Nirasawa, Takashi, Mascarelli, Frederic, Vaitinadapoule, Hanielle, Aouimeur, Ines, He, Zhiguo, Gain, Philippe, Thuret, Gilles, Koizumi, Noriko
Publicado 2023

Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy

por Okumura, Naoki, Hashimoto, Keisuke, Kitahara, Miu, Okuda, Hirokazu, Ueda, Emi, Watanabe, Kyoko, Nakahara, Makiko, Sato, Takahiko, Kinoshita, Shigeru, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Koizumi, Noriko
Publicado 2017