Molecular basis of ligand-dependent Nurr1-RXRα activation

por Yu, Xiaoyu, Shang, Jinsai, Kojetin, Douglas J
Publicado 2023

Regulation of p53 Stability and Apoptosis by a ROR Agonist

por Wang, Yongjun, Solt, Laura A., Kojetin, Douglas J., Burris, Thomas P.
Publicado 2012

Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection

por Hughes, Travis S., Wilson, Henry D., de Vera, Ian Mitchelle S., Kojetin, Douglas J.
Publicado 2015

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ

por Mosure, Sarah A., Strutzenberg, Timothy S., Shang, Jinsai, Munoz-Tello, Paola, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2021

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

por Weikum, Emily R., de Vera, Ian Mitchelle S., Nwachukwu, Jerome C., Hudson, William H., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Publicado 2017

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

por Patil, Dipak N, Rangarajan, Erumbi S, Novick, Scott J, Pascal, Bruce D, Kojetin, Douglas J, Griffin, Patrick R, Izard, Tina, Martemyanov, Kirill A
Publicado 2018

A molecular switch regulating transcriptional repression and activation of PPARγ

por Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2020

Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

por Srinivasan, Sathish, Nwachukwu, Jerome C., Parent, Alex A., Cavett, Valerie, Nowak, Jason, Hughes, Travis S., Kojetin, Douglas J., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2013

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

por Shang, Jinsai, Brust, Richard, Mosure, Sarah A, Bass, Jared, Munoz-Tello, Paola, Lin, Hua, Hughes, Travis S, Tang, Miru, Ge, Qingfeng, Kamenekca, Theodore M, Kojetin, Douglas J
Publicado 2018

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

por Hudson, William H., Vera, Ian Mitchelle S. de, Nwachukwu, Jerome C., Weikum, Emily R., Herbst, Austin G., Yang, Qin, Bain, David L., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Publicado 2018

An alternate binding site for PPARγ ligands

por Hughes, Travis S., Giri, Pankaj Kumar, de Vera, Ian Mitchelle S., Marciano, David P., Kuruvilla, Dana S., Shin, Youseung, Blayo, Anne-Laure, Kamenecka, Theodore M., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Publicado 2014

Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion

por Gamage, Dilani G., Melikov, Kamran, Munoz-Tello, Paola, Wherley, Tanner J., Focke, Leah C., Leikina, Evgenia, Huffman, Elliana, Diao, Jiajie, Kojetin, Douglas J., Prasad, Vikram, Chernomordik, Leonid V., Millay, Douglas P.
Publicado 2022

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

por Brust, Richard, Shang, Jinsai, Fuhrmann, Jakob, Mosure, Sarah A., Bass, Jared, Cano, Andrew, Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Blayo, Anne-Laure, Griffin, Patrick R., Kamenecka, Theodore M., Hughes, Travis S., Kojetin, Douglas J.
Publicado 2018

Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists

por Solt, Laura A., Wang, Yongjun, Banerjee, Subhashis, Hughes, Travis, Kojetin, Douglas J., Lundasen, Thomas, Shin, Youseung, Liu, Jin, Cameron, Michael D., Noel, Romain, Yoo, Seung-Hee, Takahashi, Joseph S., Butler, Andrew A., Kamenecka, Theodore M., Burris, Thomas P.
Publicado 2012

REV-ERBα Regulates T(H)17 Cell Development and Autoimmunity

por Amir, Mohammed, Chaudhari, Sweena, Wang, Ran, Campbell, Sean, Mosure, Sarah A., Chopp, Laura B., Lu, Qun, Shang, Jinsai, Pelletier, Oliver B., He, Yuanjun, Doebelin, Christelle, Cameron, Michael D., Kojetin, Douglas J., Kamenecka, Theodore M., Solt, Laura A.
Publicado 2018

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

por Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Publicado 2011

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

por Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M., Shulman, Andrew I., Rance, Mark, Griffin, Patrick R., Bruning, John B., Nettles, Kendall W.
Publicado 2015

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

por Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W
Publicado 2014

Pharmacological Repression of PPARγ Promotes Osteogenesis

por Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Douglas J., Phinney, Donald G., Bruning, John B., Kamenecka, Theodore M., Griffin, Patrick R.
Publicado 2015

Defining a conformational ensemble that directs activation of PPARγ

por Chrisman, Ian M., Nemetchek, Michelle D., de Vera, Ian Mitchelle S., Shang, Jinsai, Heidari, Zahra, Long, Yanan, Reyes-Caballero, Hermes, Galindo-Murillo, Rodrigo, Cheatham, Thomas E., Blayo, Anne-Laure, Shin, Youseung, Fuhrmann, Jakob, Griffin, Patrick R., Kamenecka, Theodore M., Kojetin, Douglas J., Hughes, Travis S.
Publicado 2018