Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle

por Modi, Shalem Raju, Kokkola, Tarja
Publicado 2018

Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

por Modi, Shalem, Yaluri, Nagendra, Kokkola, Tarja, Laakso, Markku
Publicado 2017

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

por Kokkola, Tarja, Savinainen, Juha R, Mönkkönen, Kati S, Retamal, Montse Durán, Laitinen, Jarmo T
Publicado 2005

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

por Yaluri, Nagendra, Modi, Shalem, López Rodríguez, Maykel, Stančáková, Alena, Kuusisto, Johanna, Kokkola, Tarja, Laakso, Markku
Publicado 2015

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

por Kokkola, Tarja, Suuronen, Tiina, Pesonen, Maija, Filippakopoulos, Panagis, Salminen, Antero, Jarho, Elina M, Lahtela-Kakkonen, Maija
Publicado 2015

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

por Oksala, Niku K.J., Ekmekçi, F. Güler, Özsoy, Ergi, Kirankaya, Şerife, Kokkola, Tarja, Emecen, Güzin, Lappalainen, Jani, Kaarniranta, Kai, Atalay, Mustafa
Publicado 2014

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

por Weiner, Sophia, Junkkari, Antti, Sauer, Mathias, Luikku, Antti, Rauramaa, Tuomas, Kokkola, Tarja, Herukka, Sanna-Kaisa, Blennow, Kaj, Zetterberg, Henrik, Leinonen, Ville, Gobom, Johan
Publicado 2023

Cerebrospinal Fluid Diagnostics of Alzheimer’s Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

por Vanninen, Aleksi, Lukkarinen, Heikki, Kokkola, Tarja, Koivisto, Anne M., Kokki, Merja, Musialowicz, Tadeusz, Hiltunen, Mikko, Zetterberg, Henrik, Leinonen, Ville, Herukka, Sanna-Kaisa, Rauramaa, Tuomas
Publicado 2023

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

por Lukkarinen, Heikki, Vanninen, Aleksi, Tesseur, Ina, Pemberton, Darrel, Van Der Ark, Peter, Kokkola, Tarja, Herukka, Sanna-Kaisa, Rauramaa, Tuomas, Hiltunen, Mikko, Blennow, Kaj, Zetterberg, Henrik, Leinonen, Ville
Publicado 2023

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

por Katisko, Kasper, Huber, Nadine, Kokkola, Tarja, Hartikainen, Päivi, Krüger, Johanna, Heikkinen, Anna-Leena, Paananen, Veera, Leinonen, Ville, Korhonen, Ville E., Helisalmi, Seppo, Herukka, Sanna-Kaisa, Cantoni, Valentina, Gadola, Yasmine, Archetti, Silvana, Remes, Anne M., Haapasalo, Annakaisa, Borroni, Barbara, Solje, Eino
Publicado 2022

A FinnGen pilot clinical recall study for Alzheimer’s disease

por Julkunen, Valtteri, Schwarz, Claudia, Kalapudas, Juho, Hallikainen, Merja, Piironen, Aino-Kaisa, Mannermaa, Arto, Kujala, Hanna, Laitinen, Timo, Kosma, Veli-Matti, Paajanen, Teemu I., Kälviäinen, Reetta, Hiltunen, Mikko, Herukka, Sanna-Kaisa, Kärkkäinen, Sari, Kokkola, Tarja, Urjansson, Mia, Perola, Markus, Palotie, Aarno, Vuoksimaa, Eero, Runz, Heiko
Publicado 2023

TWINGEN – protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer’s disease

por Vuoksimaa, Eero, Saari, Toni T., Aaltonen, Aino, Aaltonen, Sari, Herukka, Sanna-Kaisa, Iso-Markku, Paula, Kokkola, Tarja, Kyttälä, Aija, Kärkkäinen, Sari, Liedes, Hilkka, Ollikainen, Miina, Palviainen, Teemu, Ruotsalainen, Ilona, Toivola, Auli, Urjansson, Mia, Vasankari, Tommi, Vähä-Ypyä, Henri, Forsberg, Markus M., Hiltunen, Mikko, Jalanko, Anu, Kälviäinen, Reetta, Kuopio, Teijo, Lähteenmäki, Jaakko, Nyberg, Pia, Männikkö, Minna, Serpi, Raisa, Siltanen, Sanna, Palotie, Aarno, Kaprio, Jaakko, Runz, Heiko, Julkunen, Valtteri
Publicado 2023

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

por Koivula, Robert W., Atabaki-Pasdar, Naeimeh, Giordano, Giuseppe N., White, Tom, Adamski, Jerzy, Bell, Jimmy D., Beulens, Joline, Brage, Søren, Brunak, Søren, De Masi, Federico, Dermitzakis, Emmanouil T., Forgie, Ian M., Frost, Gary, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew, Kokkola, Tarja, Kurbasic, Azra, Laakso, Markku, Mari, Andrea, McDonald, Timothy J., Pedersen, Oluf, Rutters, Femke, Schwenk, Jochen M., Teare, Harriet J. A., Thomas, E. Louise, Vinuela, Ana, Mahajan, Anubha, McCarthy, Mark I., Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Pavo, Imre, Franks, Paul W.
Publicado 2020

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

por Eriksen, Rebeca, Perez, Isabel Garcia, Posma, Joram M., Haid, Mark, Sharma, Sapna, Prehn, Cornelia, Thomas, Louise E., Koivula, Robert W., Bizzotto, Roberto, Prehn, Cornelia, Mari, Andrea, Giordano, Giuseppe N., Pavo, Imre, Schwenk, Jochen M., De Masi, Federico, Tsirigos, Konstantinos D., Brunak, Søren, Viñuela, Ana, Mahajan, Anubha, McDonald, Timothy J., Kokkola, Tarja, Rutter, Femke, Teare, Harriet, Hansen, Tue H., Fernandez, Juan, Jones, Angus, Jennison, Chris, Walker, Mark, McCarthy, Mark I., Pedersen, Oluf, Ruetten, Hartmut, Forgie, Ian, Bell, Jimmy D., Pearson, Ewan R., Franks, Paul W., Adamski, Jerzy, Holmes, Elaine, Frost, Gary
Publicado 2020

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

por Obura, Morgan, Beulens, Joline W. J., Slieker, Roderick, Koopman, Anitra D. M., Hoekstra, Trynke, Nijpels, Giel, Elders, Petra, Koivula, Robert W., Kurbasic, Azra, Laakso, Markku, Hansen, Tue H., Ridderstråle, Martin, Hansen, Torben, Pavo, Imre, Forgie, Ian, Jablonka, Bernd, Ruetten, Hartmut, Mari, Andrea, McCarthy, Mark I., Walker, Mark, Heggie, Alison, McDonald, Timothy J., Perry, Mandy H., De Masi, Federico, Brunak, Søren, Mahajan, Anubha, Giordano, Giuseppe N., Kokkola, Tarja, Dermitzakis, Emmanouil, Viñuela, Ana, Pedersen, Oluf, Schwenk, Jochen M., Adamski, Jurek, Teare, Harriet J. A., Pearson, Ewan R., Franks, Paul W., ‘t Hart, Leen M., Rutters, Femke
Publicado 2020

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT...

por Koivula, Robert W., Forgie, Ian M., Kurbasic, Azra, Viñuela, Ana, Heggie, Alison, Giordano, Giuseppe N., Hansen, Tue H., Hudson, Michelle, Koopman, Anitra D. M., Rutters, Femke, Siloaho, Maritta, Allin, Kristine H., Brage, Søren, Brorsson, Caroline A., Dawed, Adem Y., De Masi, Federico, Groves, Christopher J., Kokkola, Tarja, Mahajan, Anubha, Perry, Mandy H., Rauh, Simone P., Ridderstråle, Martin, Teare, Harriet J. A., Thomas, E. Louise, Tura, Andrea, Vestergaard, Henrik, White, Tom, Adamski, Jerzy, Bell, Jimmy D., Beulens, Joline W., Brunak, Søren, Dermitzakis, Emmanouil T., Froguel, Philippe, Frost, Gary, Gupta, Ramneek, Hansen, Torben, Hattersley, Andrew, Jablonka, Bernd, Kaye, Jane, Laakso, Markku, McDonald, Timothy J., Pedersen, Oluf, Schwenk, Jochen M., Pavo, Imre, Mari, Andrea, McCarthy, Mark I., Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Franks, Paul W.
Publicado 2019

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

por Gudmundsdottir, Valborg, Pedersen, Helle Krogh, Mazzoni, Gianluca, Allin, Kristine H., Artati, Anna, Beulens, Joline W., Banasik, Karina, Brorsson, Caroline, Cederberg, Henna, Chabanova, Elizaveta, De Masi, Federico, Elders, Petra J., Forgie, Ian, Giordano, Giuseppe N., Grallert, Harald, Gupta, Ramneek, Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison, Hong, Mun-Gwan, Jones, Angus G., Koivula, Robert, Kokkola, Tarja, Laakso, Markku, Løngreen, Peter, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Musholt, Petra B., Pavo, Imre, Prehn, Cornelia, Ruetten, Hartmut, Ridderstråle, Martin, Rutters, Femke, Sharma, Sapna, Slieker, Roderick C., Syed, Ali, Tajes, Juan Fernandez, Thomas, Cecilia Engel, Thomsen, Henrik S., Vangipurapu, Jagadish, Vestergaard, Henrik, Viñuela, Ana, Wesolowska-Andersen, Agata, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., McCarthy, Mark I., Pearson, Ewan, Dermitzakis, Emmanouil, Franks, Paul W., Pedersen, Oluf, Brunak, Søren
Publicado 2020

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

por Wesolowska-Andersen, Agata, Brorsson, Caroline A., Bizzotto, Roberto, Mari, Andrea, Tura, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Prehn, Cornelia, Artati, Anna, Hong, Mun-Gwan, Musholt, Petra B., Kurbasic, Azra, De Masi, Federico, Tsirigos, Kostas, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Thomas, Cecilia Engel, Banasik, Karina, Jennison, Chrisopher, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, Louise, Frost, Gary, Thomsen, Henrik, Allin, Kristine, Hansen, Tue Haldor, Vestergaard, Henrik, Hansen, Torben, Rutters, Femke, Elders, Petra, t’Hart, Leen, Bonnefond, Amelie, Canouil, Mickaël, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Hattersley, Andrew, McDonald, Timothy, Teare, Harriet, Ridderstrale, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Froguel, Philippe, Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, Pearson, Ewan, McCarthy, Mark I., Brunak, Søren
Publicado 2022

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

por Brown, Andrew A., Fernandez-Tajes, Juan J., Hong, Mun-gwan, Brorsson, Caroline A., Koivula, Robert W., Davtian, David, Dupuis, Théo, Sartori, Ambra, Michalettou, Theodora-Dafni, Forgie, Ian M., Adam, Jonathan, Allin, Kristine H., Caiazzo, Robert, Cederberg, Henna, De Masi, Federico, Elders, Petra J. M., Giordano, Giuseppe N., Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison J., Howald, Cédric, Jones, Angus G., Kokkola, Tarja, Laakso, Markku, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Mourby, Miranda, Musholt, Petra B., Nilsson, Birgitte, Pattou, Francois, Penet, Deborah, Raverdy, Violeta, Ridderstråle, Martin, Romano, Luciana, Rutters, Femke, Sharma, Sapna, Teare, Harriet, ‘t Hart, Leen, Tsirigos, Konstantinos D., Vangipurapu, Jagadish, Vestergaard, Henrik, Brunak, Søren, Franks, Paul W., Frost, Gary, Grallert, Harald, Jablonka, Bernd, McCarthy, Mark I., Pavo, Imre, Pedersen, Oluf, Ruetten, Hartmut, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., Pearson, Ewan R., Dermitzakis, Emmanouil T., Viñuela, Ana
Publicado 2023

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

por Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Leal Rodríguez, Cristina, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, Søren
Publicado 2023