Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

por Sticher, Zachary M., Lu, Gaofei, Mitchell, Deborah G., Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R., Guthrie, David B., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A.
Publicado 2020

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

por Lu, Gaofei, Bluemling, Gregory R., Mao, Shuli, Hager, Michael, Gurale, Bharat P., Collop, Paul, Kuiper, Damien, Sana, Kasinath, Painter, George R., De La Rosa, Abel, Kolykhalov, Alexander A.
Publicado 2018

A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis

por Rab, Andras, Yang, Xun, Tracy, William F., Hong, Jeong S., Joshi, Disha, Manfredi, Candela, Ponnaluri, Sadhana S., Kolykhalov, Alexander A., Qui, Min, Fu, Haian, Du, Yuhong, Davies, Huw M. L., Sorscher, Eric J.
Publicado 2023

ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

por Squires, Katherine E., Mayers, Douglas L., Bluemling, Gregory R., Kolykhalov, Alexander A., Guthrie, David B., Reddy, Prabhakar, Mitchell, Debbie G., Saindane, Manohar T., Sticher, Zachary M., Edpuganti, Vindhya, De La Rosa, Abel
Publicado 2020

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

por McGuigan, Christopher, Bourdin, Claire, Derudas, Marco, Hamon, Nadège, Hinsinger, Karen, Kandil, Sahar, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio, Serpi, Michaela, Slusarczyk, Magdalena, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid, Balzarini, Jan
Publicado 2013

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

por Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.
Publicado 2023

4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

por Sourimant, Julien, Lieber, Carolin M., Aggarwal, Megha, Cox, Robert M., Wolf, Josef D., Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A., Martinez-Sobrido, Luis, Bluemling, Gregory R., Natchus, Michael G., Painter, George R., Plemper, Richard K.
Publicado 2021

Orally Efficacious Broad-Spectrum Allosteric Inhibitor of Paramyxovirus Polymerase

por Cox, Robert M, Sourimant, Julien, Toots, Mart, Yoon, Jeong-Joong, Ikegame, Satoshi, Govindarajan, Mugunthan, Watkinson, Ruth E, Thibault, Patricia, Makhsous, Negar, Lin, Michelle J., Marengo, Jose R, Sticher, Zachary, Kolykhalov, Alexander A, Natchus, Michael G, Greninger, Alexander L, Lee, Benhur, Plemper, Richard K
Publicado 2020

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

por Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Publicado 2019

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

por Lieber, Carolin M., Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M., Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K., Jones, Cheryl A., Sticher, Zachary M., Kolykhalov, Alexander A., Saindane, Manohar T., Tompkins, Stephen M., Planz, Oliver, Painter, George R., Natchus, Michael G., Sakamoto, Kaori, Plemper, Richard K.
Publicado 2023

Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model

por Suhy, David A, Kao, Shih-Chu, Mao, Tin, Whiteley, Laurence, Denise, Hubert, Souberbielle, Bernard, Burdick, Andrew D, Hayes, Kyle, Wright, J Fraser, Lavender, Helen, Roelvink, Peter, Kolykhalov, Alexander, Brady, Kevin, Moschos, Sterghios A, Hauck, Bernd, Zelenaia, Olga, Zhou, Shangzhen, Scribner, Curt, High, Katherine A, Renison, Sara H, Corbau, Romu
Publicado 2012

Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 M(pro) Inhibitors

por Jacobs, Leon, van der Westhuyzen, Aletta, Pribut, Nicole, Dentmon, Zackery W., Cui, Dan, D’Erasmo, Michael P., Bartsch, Perry W., Liu, Ken, Cox, Robert M., Greenlund, Sujay F., Plemper, Richard K., Mitchell, Deborah, Marlow, Joshua, Andrews, Meghan K., Krueger, Rebecca E., Sticher, Zachary M., Kolykhalov, Alexander A., Natchus, Michael G., Zhou, Bin, Pelly, Stephen C., Liotta, Dennis C.
Publicado 2023

SARS-CoV-2 Infection is Effectively Treated and Prevented by EIDD-2801

por Wahl, Angela, Gralinski, Lisa E., Johnson, Claire E., Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth H., Liu, Hongwei, Madden, Victoria J., Krzystek, Halina M., De, Chandrav, White, Kristen K., Gully, Kendra, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah R., Grant, Paul O., Bluemling, Gregory R., Kolykhalov, Alexander A., Natchus, Michael G., Askin, Frederic B., Painter, George, Browne, Edward P., Jones, Corbin D., Pickles, Raymond J., Baric, Ralph S., Garcia, J. Victor
Publicado 2021

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

por Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.
Publicado 2020