Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine

por Mizobuchi, Yusuke, Miyano, Kanako, Manabe, Sei, Uezono, Eiko, Komatsu, Akane, Kuroda, Yui, Nonaka, Miki, Matsuoka, Yoshikazu, Sato, Tetsufumi, Uezono, Yasuhito, Morimatsu, Hiroshi
Publicado 2022

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

por Karasawa, Yusuke, Miyano, Kanako, Fujii, Hideaki, Mizuguchi, Takaaki, Kuroda, Yui, Nonaka, Miki, Komatsu, Akane, Ohshima, Kaori, Yamaguchi, Masahiro, Yamaguchi, Keisuke, Iseki, Masako, Uezono, Yasuhito, Hayashida, Masakazu
Publicado 2021

Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl: Possible Opioid Switching Altern...

por Komatsu, Akane, Miyano, Kanako, Nakayama, Daisuke, Mizobuchi, Yusuke, Uezono, Eiko, Ohshima, Kaori, Karasawa, Yusuke, Kuroda, Yui, Nonaka, Miki, Yamaguchi, Keisuke, Iseki, Masako, Uezono, Yasuhito, Hayashida, Masakazu
Publicado 2022

Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways...

por Yamaguchi, Masahiro, Miyano, Kanako, Hirayama, Shigeto, Karasawa, Yusuke, Ohshima, Kaori, Uezono, Eiko, Komatsu, Akane, Nonaka, Miki, Fujii, Hideaki, Yamaguchi, Keisuke, Iseki, Masako, Hayashida, Masakazu, Uezono, Yasuhito
Publicado 2022

Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses

por Uezono, Eiko, Mizobuchi, Yusuke, Miyano, Kanako, Ohbuchi, Katsuya, Murata, Hiroaki, Komatsu, Akane, Manabe, Sei, Nonaka, Miki, Hirokawa, Takatsugu, Yamaguchi, Keisuke, Iseki, Masako, Uezono, Yasuhito, Hayashida, Masakazu, Kawagoe, Izumi
Publicado 2023

Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway

por Miyano, Kanako, Yoshida, Yuki, Hirayama, Shigeto, Takahashi, Hideki, Ono, Haruka, Meguro, Yoshiyuki, Manabe, Sei, Komatsu, Akane, Nonaka, Miki, Mizuguchi, Takaaki, Fujii, Hideaki, Higami, Yoshikazu, Narita, Minoru, Uezono, Yasuhito
Publicado 2021