Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation

por Yee, Yi Hui, Chong, Stephen Jun Fei, Kong, Li Ren, Goh, Boon Cher, Pervaiz, Shazib
Publicado 2020

Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy

por Li, Jiaqi, Eu, Jie Qing, Kong, Li Ren, Wang, Lingzhi, Lim, Yaw Chyn, Goh, Boon Cher, Wong, Andrea L. A.
Publicado 2020

A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells

por Najafabadi, Maryam Ghaderi, Gray, G. Kenneth, Kong, Li Ren, Gupta, Komal, Perera, David, Naylor, Huw, Brugge, Joan S., Venkitaraman, Ashok R., Shehata, Mona
Publicado 2023

Anti-Malarial Drug Artesunate Attenuates Experimental Allergic Asthma via Inhibition of the Phosphoinositide 3-Kinase/Akt Pathway

por Cheng, Chang, Ho, W. Eugene, Goh, Fera Y., Guan, Shou Ping, Kong, Li Ren, Lai, Wen-Qi, Leung, Bernard P., Wong, W. S. Fred
Publicado 2011

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carci...

por Chua, Kian Ngiap, Kong, Li Ren, Sim, Wen Jing, Ng, Hsien Chun, Ong, Weijie Richard, Thiery, Jean Paul, Huynh, Hung, Goh, Boon Cher
Publicado 2015

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

por Hirpara, Jayshree, Eu, Jie Qing, Tan, Joanna Kia Min, Wong, Andrea L., Clement, Marie-Veronique, Kong, Li Ren, Ohi, Naoto, Tsunoda, Takeshi, Qu, Jianhua, Goh, Boon Cher, Pervaiz, Shazib
Publicado 2018

Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models

por Syn, Nicholas L., Lim, Pei Li, Kong, Li Ren, Wang, Lingzhi, Wong, Andrea Li-Ann, Lim, Chwee Ming, Loh, Thomas Kwok Seng, Siemeister, Gerhard, Goh, Boon Cher, Hsieh, Wen-Son
Publicado 2018

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

por Kong, Li Ren, Ong, Richard Weijie, Tan, Tuan Zea, Mohamed Salleh, Nur Afiqah Binte, Thangavelu, Matan, Chan, Jane Vin, Koh, Lie Yong Judice, Periyasamy, Giridharan, Lau, Jieying Amelia, Le, Thi Bich Uyen, Wang, Lingzhi, Lee, Miyoung, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Chwee Ming, Chng, Wee Joo, Lane, David P., Venkitaraman, Ashok, Hung, Huynh The, Cheok, Chit Fang, Goh, Boon Cher
Publicado 2020

DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

por Low, Heng Boon, Wong, Zhen Lim, Wu, Bangyuan, Kong, Li Ren, Png, Chin Wen, Cho, Yik-Lam, Li, Chun-Wei, Xiao, Fengchun, Xin, Xuan, Yang, Henry, Loo, Jia Min, Lee, Fiona Yi Xin, Tan, Iain Bee Huat, DasGupta, Ramanuj, Shen, Han-Ming, Schwarz, Herbert, Gascoigne, Nicholas R. J., Goh, Boon Cher, Xu, Xiaohong, Zhang, Yongliang
Publicado 2021

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

por Kong, Li Ren, Mohamed Salleh, Nur Afiqah Binte, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L., Goh, Robby Miguel, Fhu, Chee Wai, Tan, Daniel S. W., Iyer, N. Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline S. J., Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H. Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher
Publicado 2020

FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites

por Thuya, Win Lwin, Kong, Li Ren, Syn, Nicholas L., Ding, Ling-Wen, Cheow, Esther Sok Hwee, Wong, Regina Tong Xin, Wang, Tingting, Goh, Robby Miguel Wen-Jing, Song, Hongyan, Jayasinghe, Migara K., Le, Minh TN, Hu, Jian Cheng, Yong, Wei-Peng, Lee, Soo-Chin, Wong, Andrea Li-Ann, Sethi, Gautam, Hung, Huynh The, Ho, Paul Chi-Lui, Thiery, Jean-Paul, Sze, Siu Kwan, Guo, Tiannan, Soo, Ross A., Yang, Henry, Lim, Yaw Chyn, Wang, Lingzhi, Goh, Boon-Cher
Publicado 2023