Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA(A) Receptors

por Fabjan, Jure, Koniuszewski, Filip, Schaar, Benjamin, Ernst, Margot
Publicado 2021

Cys-loop receptors on cannabinoids: All high?

por Schmiedhofer, Philip, Vogel, Florian Daniel, Koniuszewski, Filip, Ernst, Margot
Publicado 2022

Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond

por Koniuszewski, Filip, Vogel, Florian D., Dajić, Irena, Seidel, Thomas, Kunze, Markus, Willeit, Matthäus, Ernst, Margot
Publicado 2023

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels

por Koniuszewski, Filip, Vogel, Florian D., Bampali, Konstantina, Fabjan, Jure, Seidel, Thomas, Scholze, Petra, Schmiedhofer, Philip B., Langer, Thierry, Ernst, Margot
Publicado 2022

GABA(A) Receptor Ligands Often Interact with Binding Sites in the Transmembrane Domain and in the Extracellular Domain—Can the Promiscuity Code Be Cracked?

por Iorio, Maria Teresa, Vogel, Florian Daniel, Koniuszewski, Filip, Scholze, Petra, Rehman, Sabah, Simeone, Xenia, Schnürch, Michael, Mihovilovic, Marko D., Ernst, Margot
Publicado 2020

A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype

por Vogel, Florian D., Krenn, Martin, Westphal, Dominik S., Graf, Elisabeth, Wagner, Matias, Leiz, Steffen, Koniuszewski, Filip, Augé‐Stock, Maximilian, Kramer, Georg, Scholze, Petra, Ernst, Margot
Publicado 2022

Tricyclic antipsychotics and antidepressants can inhibit α5‐containing GABA(A) receptors by two distinct mechanisms

por Bampali, Konstantina, Koniuszewski, Filip, Silva, Luca L., Rehman, Sabah, Vogel, Florian D., Seidel, Thomas, Scholze, Petra, Zirpel, Florian, Garon, Arthur, Langer, Thierry, Willeit, Matthäus, Ernst, Margot
Publicado 2022

GABA(A) receptor-mediated seizure liabilities: a mixed-methods screening approach

por Bampali, Konstantina, Koniuszewski, Filip, Vogel, Florian D., Fabjan, Jure, Andronis, Christos, Lekka, Eftychia, Virvillis, Vassilis, Seidel, Thomas, Delaunois, Annie, Royer, Leandro, Rolf, Michael G., Giuliano, Chiara, Traebert, Martin, Roussignol, Gautier, Fric-Bordat, Magali, Mazelin-Winum, Ludmilla, Bryant, Sharon D., Langer, Thierry, Ernst, Margot
Publicado 2023