Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents

por Konrad, Robert J, Troutt, Jason S, Cao, Guoqing
Publicado 2011

The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes

por Zughaier, Susu M., Alvarez, Jessica A., Sloan, John H., Konrad, Robert J., Tangpricha, Vin
Publicado 2014

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

por Chen, Yan Q., Pottanat, Thomas G., Siegel, Robert W., Ehsani, Mariam, Qian, Yue-Wei, Konrad, Robert J.
Publicado 2021

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

por Chen, Yan Q., Zhen, Eugene Y., Russell, Anna M., Ehsani, Mariam, Siegel, Robert W., Qian, Yuewei, Konrad, Robert J.
Publicado 2023

Serum Hepcidin Levels Are Associated With Obesity but Not Liver Disease

por Vuppalanchi, Raj, Troutt, Jason S, Konrad, Robert J., Ghabril, Marwan, Saxena, Romil, Bell, Lauren N, Kowdley, Kris V., Chalasani, Naga
Publicado 2013

The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein

por Knierman, Michael D., Lannan, Megan B., Spindler, Laura J., McMillian, Carl L., Konrad, Robert J., Siegel, Robert W.
Publicado 2020

Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity

por Zhen, Eugene Y., Chen, Yan Q., Russell, Anna M., Ehsani, Mariam, Siegel, Robert W., Qian, Yuewei, Konrad, Robert J.
Publicado 2023

Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans

por Lehtihet, Mikael, Bonde, Ylva, Beckman, Lena, Berinder, Katarina, Hoybye, Charlotte, Rudling, Mats, Sloan, John H., Konrad, Robert J., Angelin, Bo
Publicado 2016

ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition

por Chen, Yan Q., Pottanat, Thomas G., Zhen, Eugene Y., Siegel, Robert W., Ehsani, Mariam, Qian, Yue-Wei, Konrad, Robert J.
Publicado 2021

Clinical Outcomes of Patients with Diabetes Who Exhibit Upper-Quartile Insulin Antibody Responses After Treatment with LY2963016 or Lantus(®) Insulin Glargine

por Ilag, Liza L., Costigan, Timothy M., Deeg, Mark A., Pollom, Robyn K., Chang, Curtis L., Konrad, Robert J., Prince, Melvin J.
Publicado 2017

Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay

por Konrad, Robert J., Higgs, Richard E., Rodgers, George H., Ming, Wenyu, Qian, Yue-Wei, Bivi, Nicoletta, Mack, Justin K., Siegel, Robert W., Nickoloff, Brian J.
Publicado 2019

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

por Avin, Keith G., Chen, Neal X., Organ, Jason M., Zarse, Chad, O’Neill, Kalisha, Conway, Richard G., Konrad, Robert J., Bacallao, Robert L., Allen, Matthew R., Moe, Sharon M.
Publicado 2016

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

por ten Kulve, Jennifer S., Veltman, Dick J., van Bloemendaal, Liselotte, Barkhof, Frederik, Deacon, Carolyn F., Holst, Jens J., Konrad, Robert J., Sloan, John H., Drent, Madeleine L., Diamant, Michaela, IJzerman, Richard G.
Publicado 2015

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk

por Bivi, Nicoletta, Moore, Terry, Rodgers, George, Denning, Heather, Shockley, Travis, Swearingen, Craig A., Gelfanova, Valentina, Calderon, Boris, Peterson, Daniel A., Hodsdon, Michael E., Siegel, Robert W., Higgs, Richard E., Konrad, Robert J.
Publicado 2019

Tumor Cell Expression of Vascular Endothelial Growth Factor Receptor 2 Is an Adverse Prognostic Factor in Patients with Squamous Cell Carcinoma of the Lung

por Holzer, Timothy R., Fulford, Angie D., Nedderman, Drew M., Umberger, Tara S., Hozak, Rebecca R., Joshi, Adarsh, Melemed, Symantha A., Benjamin, Laura E., Plowman, Gregory D., Schade, Andrew E., Ackermann, Bradley L., Konrad, Robert J., Nasir, Aejaz
Publicado 2013

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids

por Chen, Yan Q., Pottanat, Thomas G., Siegel, Robert W., Ehsani, Mariam, Qian, Yue-Wei, Zhen, Eugene Y., Regmi, Ajit, Roell, William C., Guo, Haihong, Luo, M. Jane, Gimeno, Ruth E., van’t Hooft, Ferdinand, Konrad, Robert J.
Publicado 2020

Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

por Sims, Jonathan T., Krishnan, Venkatesh, Chang, Ching-Yun, Engle, Sarah M., Casalini, Giacomo, Rodgers, George H., Bivi, Nicoletta, Nickoloff, Brian J., Konrad, Robert J., de Bono, Stephanie, Higgs, Richard E., Benschop, Robert J., Ottaviani, Silvia, Cardoso, Anabela, Nirula, Ajay, Corbellino, Mario, Stebbing, Justin
Publicado 2021

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

por Balasubramaniam, Deepa, Schroeder, Oliver, Russell, Anna M., Fitchett, Jonathan R., Austin, Aaron K., Beyer, Thomas P., Chen, Yan Q., Day, Jonathan W., Ehsani, Mariam, Heng, Aik Roy, Zhen, Eugene Y., Davies, Julian, Glaesner, Wolfgang, Jones, Bryan E., Siegel, Robert W., Qian, Yue-Wei, Konrad, Robert J.
Publicado 2022

Effect of Costimulatory Blockade With Abatacept After Ustekinumab Withdrawal in Patients With Moderate to Severe Plaque Psoriasis: The PAUSE Randomized Clinical Trial

por Harris, Kristina M., Smilek, Dawn E., Byron, Margie, Lim, Noha, Barry, William T., McNamara, James, Garcet, Sandra, Konrad, Robert J., Stengelin, Martin, Bathala, Pradeepthi, Korman, Neil J., Feldman, Steven R., Boh, Erin E., Barber, Kirk, Laumann, Anne E., Helfrich, Yolanda Rosi, Krueger, Gerald G., Sofen, Howard, Bissonnette, Robert, Krueger, James G.
Publicado 2021

Hypertriglyceridemia in Apoa5(–/–) mice results from reduced amounts of lipoprotein lipase in the capillary lumen

por Yang, Ye, Beigneux, Anne P., Song, Wenxin, Nguyen, Le Phuong, Jung, Hyesoo, Tu, Yiping, Weston, Thomas A., Tran, Caitlyn M., Xie, Katherine, Yu, Rachel G., Tran, Anh P., Miyashita, Kazuya, Nakajima, Katsuyuki, Murakami, Masami, Chen, Yan Q., Zhen, Eugene Y., Kim, Joonyoung R., Kim, Paul H., Birrane, Gabriel, Tontonoz, Peter, Ploug, Michael, Konrad, Robert J., Fong, Loren G., Young, Stephen G.
Publicado 2023