Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

por Asencio, Anthony, Malingen, Sage, Kooiker, Kristina B., Powers, Joseph D., Davis, Jennifer, Daniel, Thomas, Moussavi-Harami, Farid
Publicado 2023

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

por Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Publicado 2019

Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C

por Stern, Joshua A., Rivas, Victor N., Kaplan, Joanna L., Ueda, Yu, Oldach, Maureen S., Ontiveros, Eric S., Kooiker, Kristina B., van Dijk, Sabine J., Harris, Samantha P.
Publicado 2023

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

por Powers, Joseph D., Kooiker, Kristina B., Mason, Allison B., Teitgen, Abigail E., Flint, Galina V., Tardiff, Jil C., Schwartz, Steven D., McCulloch, Andrew D., Regnier, Michael, Davis, Jennifer, Moussavi-Harami, Farid
Publicado 2020

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

por Quarles, Ellen, Basisty, Nathan, Chiao, Ying Ann, Merrihew, Gennifer, Gu, Haiwei, Sweetwyne, Mariya T., Fredrickson, Jeanne, Nguyen, Ngoc‐Han, Razumova, Maria, Kooiker, Kristina, Moussavi‐Harami, Farid, Regnier, Michael, Quarles, Christopher, MacCoss, Michael, Rabinovitch, Peter S.
Publicado 2019

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

por Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
Publicado 2021

Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle

por Kooiker, Kristina B., Mohran, Saffie, Turner, Kyrah L., Ma, Weikang, Martinson, Amy, Flint, Galina, Qi, Lin, Gao, Chengqian, Zheng, Yahan, McMillen, Timothy S., Mandrycky, Christian, Mahoney-Schaefer, Max, Freeman, Jeremy C., Costales Arenas, Elijah Gabriela, Tu, An-Yu, Irving, Thomas C., Geeves, Michael A., Tanner, Bertrand C.W., Regnier, Michael, Davis, Jennifer, Moussavi-Harami, Farid
Publicado 2023