Exposure–response relationships of dapagliflozin on cardiorenal risk markers and adverse events: A pooled analysis of 13 phase II/III trials

por Koomen, Jeroen V., Stevens, Jasper, Heerspink, Hiddo J.L.
Publicado 2020

Optimized infusion rates for N,N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework

por Eckernäs, Emma, Koomen, Jeroen, Timmermann, Christopher, Carhart‐Harris, Robin, Röshammar, Daniel, Ashton, Michael
Publicado 2023

A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe

por Koomen, Jeroen V., Stevens, Jasper, Monster-Simons, Margje H., Heerspink, Hiddo J. L., Mol, Peter G. M.
Publicado 2021

Determining the optimal dose of atrasentan by evaluating the exposure‐response relationships of albuminuria and bodyweight

por Koomen, Jeroen V., Stevens, Jasper, Mostafa, Nael M., Parving, Hans‐Henrik, de Zeeuw, Dick, Heerspink, Hiddo J. L.
Publicado 2018

Exposure–response relationships for the sodium‐glucose co‐transporter‐2 inhibitor dapagliflozin with regard to renal risk markers

por Kroonen, Marjolein Y. A. M., Koomen, Jeroen V., Petrykiv, Sergei I., Laverman, Gozewijn D., Heerspink, Hiddo J. L., Stevens, Jasper
Publicado 2020

A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients

por Koomen, Jeroen V., Knobbe, Tim J., Zijp, Tanja R., Kremer, Daan, Gan, C. Tji, Verschuuren, Erik A. M., Bakker, Stephan J. L., Touw, Daan J., Colin, Pieter J.
Publicado 2023

Peri-Operative Kinetics of Plasma Mitochondrial DNA Levels during Living Donor Kidney Transplantation

por Kroneisl, Marie, Spraakman, Nora A., Koomen, Jeroen V., Hijazi, Zeinab, Hoogstra-Berends, Femke H., Leuvenink, Henri G. D., Struys, Michel M. R. F., Henning, Rob H., Nieuwenhuijs-Moeke, Gertrude J.
Publicado 2023

Exposure and response analysis of aleglitazar on cardiovascular risk markers and safety outcomes: An analysis of the AleCardio trial

por Koomen, Jeroen V., Heerspink, Hiddo J. L., Schrieks, Ilse C., Schwartz, Gregory G., Lincoff, A. Michael, Nicholls, Stephen J., Svensson, Anders, Wedel, Hans, Weichert, Arlette, Grobbee, Diederick E., Stevens, Jasper
Publicado 2019

Exposure–Response Analysis of the Sodium–Glucose Cotransporter-2 Inhibitors Dapagliflozin and Empagliflozin on Kidney Hemodynamics in Patients with Type 2 Diabetes

por van der Hoek, Sjoukje, Koomen, Jeroen V., van Bommel, Erik J. M., Mosterd, Charlotte M., Scholtes, Rosalie A., Hesp, Anne C., Stevens, Jasper, van Raalte, Daniel H., Heerspink, Hiddo J. L.
Publicado 2023

Urinary Biomarkers in a Living Donor Kidney Transplantation Cohort—Predictive Value on Graft Function

por Huisman, G. J. Julia, Spraakman, Nora A., Koomen, Jeroen V., Talsma, A. Marrit, Pol, Robert A., Berger, Stefan P., Leuvenink, Henri G. D., Struys, Michel M. R. F., Nieuwenhuijs-Moeke, Gertrude J.
Publicado 2023

Optimising the Nadroparin Dose for Thromboprophylaxis During Hemodialysis by Developing a Population Pharmacodynamic Model Using Anti-Xa Levels

por Jaspers, Tessa C. C., Meijer, Charlotte E., Vleming, Louis Jean, Franssen, Casper F. M., Diepstraten, Jeroen, Lukens, Michael V., van den Bemt, Patricia M. L. A., Maat, Barbara, Khorsand, Nakisa, Touw, Daniël J., Koomen, Jeroen V.
Publicado 2022

Inter‐individual variability in atrasentan exposure partly explains variability in kidney protection and fluid retention responses: A post hoc analysis of the SONAR trial

por Koomen, Jeroen V., Stevens, Jasper, Bakris, George, Correa‐Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John J. V., Parving, Hans‐Henrik, Perkovic, Vlado, Tobe, Sheldon W., de Zeeuw, Dick, Heerspink, Hiddo J. L.
Publicado 2020

Individual Atrasentan Exposure is Associated With Long‐term Kidney and Heart Failure Outcomes in Patients With Type 2 Diabetes and Chronic Kidney Disease

por Koomen, Jeroen V., Stevens, Jasper, Bakris, George, Correa‐Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald E., Makino, Hirofumi, McMurray, John J. V., Parving, Hans‐Henrik, Perkovic, Vlado, Tobe, Sheldon W., de Zeeuw, Dick, Heerspink, Hiddo J. L.
Publicado 2021

Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long‐Term Response to Atrasentan in Patients With Diabetic Kidney Disease

por Smeijer, J. David, Koomen, Jeroen V., Kohan, Donald E., McMurray, John J. V., Bakris, George L., Correa‐Rotter, Ricardo, Hou, Fan‐Fan, Kitzman, Dalane W., Makino, Hirofumi, Mayer, Gert, Nowicki, Michal, Perkovic, Vlado, Rossing, Peter, Tobe, Sheldon, Parving, Hans‐Henrik, de Zeeuw, Dick, Heerspink, Hiddo J. L.
Publicado 2022

Evaluation of the Pharmacokinetics and Exposure–Response Relationship of Dapagliflozin in Patients without Diabetes and with Chronic Kidney Disease

por van der Aart-van der Beek, Annemarie B., Koomen, Jeroen V., Dekkers, Claire C. J., Barbour, Sean J., Boulton, David W., Gansevoort, Ron T., Greasley, Peter J., Abdul Gafor, Abdul Halim, Laverman, Gozewijn D., Li, Qiang, Lim, Soo Kun, Stevens, Jasper, Vervloet, Marc G., Singh, Sunita, Cattran, Daniel C., Reich, Heather N., Cherney, David Z. I., Heerspink, Hiddo J. L.
Publicado 2021