Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

por Koprich, James B, Reske-Nielsen, Casper, Mithal, Prabhakar, Isacson, Ole
Publicado 2008

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Ex...

por Koprich, James B., Johnston, Tom H., Reyes, Gabriela, Omana, Vanessa, Brotchie, Jonathan M.
Publicado 2016

Exosome markers of LRRK2 kinase inhibition

por Wang, Shijie, Kelly, Kaela, Brotchie, Jonathan M., Koprich, James B., West, Andrew B.
Publicado 2020

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite...

por Koprich, James B, Johnston, Tom H, Reyes, M Gabriela, Sun, Xuan, Brotchie, Jonathan M
Publicado 2010

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease

por Schneider, Jay S., Aras, Radha, Williams, Courtney K., Koprich, James B., Brotchie, Jonathan M., Singh, Vikrant
Publicado 2019

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

por Koprich, James B., Johnston, Tom H., Huot, Philippe, Reyes, M. Gabriela, Espinosa, Maria, Brotchie, Jonathan M.
Publicado 2011

Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α‐synuclein Parkinson's disease rat model

por Musacchio, Thomas, Rebenstorff, Maike, Fluri, Felix, Brotchie, Jonathan M., Volkmann, Jens, Koprich, James B., Ip, Chi Wang
Publicado 2017

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

por Grotemeyer, Alexander, Fischer, Judith F., Koprich, James B., Brotchie, Jonathan M., Blum, Robert, Volkmann, Jens, Ip, Chi Wang
Publicado 2023

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

por Titze-de-Almeida, Simoneide S., Soto-Sánchez, Cristina, Fernandez, Eduardo, Koprich, James B., Brotchie, Jonathan M., Titze-de-Almeida, Ricardo
Publicado 2020

Non-steric-zipper models for pathogenic α-synuclein conformers

por Schuman, Brock, Won, Amy, Brand-Arzamendi, Koroboshka, Koprich, James B., Wen, Xiao-Yan, Howson, Patrick A., Brotchie, Jonathan M., Yip, Christopher M.
Publicado 2018

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new m...

por Ip, Chi Wang, Klaus, Laura-Christin, Karikari, Akua A., Visanji, Naomi P., Brotchie, Jonathan M., Lang, Anthony E., Volkmann, Jens, Koprich, James B.
Publicado 2017

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice

por Badr, Mohammad, McFleder, Rhonda L., Wu, Jingjing, Knorr, Susanne, Koprich, James B., Hünig, Thomas, Brotchie, Jonathan M., Volkmann, Jens, Lutz, Manfred B., Ip, Chi Wang
Publicado 2022

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

por Henrich, Martin Timo, Geibl, Fanni Fruzsina, Lee, Bolam, Chiu, Wei-Hua, Koprich, James Benjamin, Brotchie, Jonathan Michael, Timmermann, Lars, Decher, Niels, Matschke, Lina Anita, Oertel, Wolfgang Hermann
Publicado 2018

α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

por Chiu, Wei-Hua, Kovacheva, Lora, Musgrove, Ruth E., Arien-Zakay, Hadar, Koprich, James B., Brotchie, Jonathan M., Yaka, Rami, Ben-Zvi, Danny, Hanani, Menachem, Roeper, Jochen, Goldberg, Joshua A.
Publicado 2021

Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury

por Ip, Chi Wang, Isaias, Ioannis U., Kusche-Tekin, Burak B., Klein, Dennis, Groh, Janos, O’Leary, Aet, Knorr, Susanne, Higuchi, Takahiro, Koprich, James B., Brotchie, Jonathan M., Toyka, Klaus V., Reif, Andreas, Volkmann, Jens
Publicado 2016

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

por McKinnon, Chris, De Snoo, Mitchell L., Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G., O’Hara, Darren M., Brotchie, Jonathan M., Koprich, James B., Lozano, Andres M., Kalia, Lorraine V., Kalia, Suneil K.
Publicado 2020

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

por Taymans, Jean-Marc, Mutez, Eugénie, Sibran, William, Vandewynckel, Laurine, Deldycke, Claire, Bleuse, Séverine, Marchand, Antoine, Sarchione, Alessia, Leghay, Coline, Kreisler, Alexandre, Simonin, Clémence, Koprich, James, Baille, Guillaume, Defebvre, Luc, Dujardin, Kathy, Destée, Alain, Chartier-Harlin, Marie-Christine
Publicado 2023

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

por Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Publicado 2022

Brain-to-gut trafficking of alpha-synuclein by CD11c(+) cells in a mouse model of Parkinson’s disease

por McFleder, Rhonda L., Makhotkina, Anastasiia, Groh, Janos, Keber, Ursula, Imdahl, Fabian, Peña Mosca, Josefina, Peteranderl, Alina, Wu, Jingjing, Tabuchi, Sawako, Hoffmann, Jan, Karl, Ann-Kathrin, Pagenstecher, Axel, Vogel, Jörg, Beilhack, Andreas, Koprich, James B., Brotchie, Jonathan M., Saliba, Antoine-Emmanuel, Volkmann, Jens, Ip, Chi Wang
Publicado 2023