Vascular Endothelial Cells: Heterogeneity and Targeting Approaches

por Hennigs, Jan K., Matuszcak, Christiane, Trepel, Martin, Körbelin, Jakob
Publicado 2021

Transcription factors in the pathogenesis of pulmonary arterial hypertension—Current knowledge and therapeutic potential

por Körbelin, Jakob, Klein, Julius, Matuszcak, Christiane, Runge, Johannes, Harbaum, Lars, Klose, Hans, Hennigs, Jan K.
Publicado 2023

Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair

por Mehina, Eslam M. F., Taylor, Stephanie, Boghozian, Roobina, White, Emily, Choi, Sun Eui, Cheema, Manjinder S., Korbelin, Jakob, Brown, Craig E.
Publicado 2021

Peptide Ligands Incorporated into the Threefold Spike Capsid Domain to Re-Direct Gene Transduction of AAV8 and AAV9 In Vivo

por Michelfelder, Stefan, Varadi, Karl, Raupp, Christina, Hunger, Agnes, Körbelin, Jakob, Pahrmann, Christiane, Schrepfer, Sonja, Müller, Oliver J., Kleinschmidt, Jürgen A., Trepel, Martin
Publicado 2011

A novel strategy for delivering Niemann‐Pick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus

por Rasmussen, Charlotte Laurfelt Munch, Hede, Eva, Routhe, Lisa Juul, Körbelin, Jakob, Helgudottir, Steinunn Sara, Thomsen, Louiza Bohn, Schwaninger, Markus, Burkhart, Annette, Moos, Torben
Publicado 2022

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

por Eichhoff, Anna Marei, Börner, Kathleen, Albrecht, Birte, Schäfer, Waldemar, Baum, Natalie, Haag, Friedrich, Körbelin, Jakob, Trepel, Martin, Braren, Ingke, Grimm, Dirk, Adriouch, Sahil, Koch-Nolte, Friedrich
Publicado 2019

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

por Körbelin, Jakob, Dogbevia, Godwin, Michelfelder, Stefan, Ridder, Dirk A, Hunger, Agnes, Wenzel, Jan, Seismann, Henning, Lampe, Melanie, Bannach, Jacqueline, Pasparakis, Manolis, Kleinschmidt, Jürgen A, Schwaninger, Markus, Trepel, Martin
Publicado 2016

Respiratory muscle dysfunction in long-COVID patients

por Hennigs, Jan K., Huwe, Marie, Hennigs, Annette, Oqueka, Tim, Simon, Marcel, Harbaum, Lars, Körbelin, Jakob, Schmiedel, Stefan, Schulze zur Wiesch, Julian, Addo, Marylyn M., Kluge, Stefan, Klose, Hans
Publicado 2022

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

por Nikolakopoulou, Angeliki Maria, Wang, Yaoming, Ma, Qingyi, Sagare, Abhay P., Montagne, Axel, Huuskonen, Mikko T., Rege, Sanket V., Kisler, Kassandra, Dai, Zhonghua, Körbelin, Jakob, Herz, Joachim, Zhao, Zhen, Zlokovic, Berislav V.
Publicado 2021

Gene therapy targeting the blood–brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

por Sundaram, Sivaraj M, Arrulo Pereira, Adriana, Müller-Fielitz, Helge, Köpke, Hannes, De Angelis, Meri, Müller, Timo D, Heuer, Heike, Körbelin, Jakob, Krohn, Markus, Mittag, Jens, Nogueiras, Ruben, Prevot, Vincent, Schwaninger, Markus
Publicado 2022

Antigen recognition detains CD8(+) T cells at the blood-brain barrier and contributes to its breakdown

por Aydin, Sidar, Pareja, Javier, Schallenberg, Vivianne M., Klopstein, Armelle, Gruber, Thomas, Page, Nicolas, Bouillet, Elisa, Blanchard, Nicolas, Liblau, Roland, Körbelin, Jakob, Schwaninger, Markus, Johnson, Aaron J., Schenk, Mirjam, Deutsch, Urban, Merkler, Doron, Engelhardt, Britta
Publicado 2023

The HDL particle composition determines its antitumor activity in pancreatic cancer

por Oberle, Raimund, Kührer, Kristina, Österreicher, Tamina, Weber, Florian, Steinbauer, Stefanie, Udonta, Florian, Wroblewski, Mark, Ben-Batalla, Isabel, Hassl, Ingrid, Körbelin, Jakob, Unseld, Matthias, Jauhiainen, Matti, Plochberger, Birgit, Röhrl, Clemens, Hengstschläger, Markus, Loges, Sonja, Stangl, Herbert
Publicado 2022

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

por Isobe, Sarasa, Nair, Ramesh V., Kang, Helen Y., Wang, Lingli, Moonen, Jan-Renier, Shinohara, Tsutomu, Cao, Aiqin, Taylor, Shalina, Otsuki, Shoichiro, Marciano, David P., Harper, Rebecca L., Adil, Mir S., Zhang, Chongyang, Lago-Docampo, Mauro, Körbelin, Jakob, Engreitz, Jesse M., Snyder, Michael P., Rabinovitch, Marlene
Publicado 2023

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations

por Ren, Jian, Huang, Yazi, Ren, Yeqing, Tu, Tianqi, Qiu, Baoshan, Ai, Daosheng, Bi, Zhanying, Bai, Xue, Li, Fengzhi, Li, Jun-Liszt, Chen, Xing-jun, Feng, Ziyan, Guo, Zongpei, Lei, Jianfeng, Tian, An, Cui, Ziwei, Lindner, Volkhard, Adams, Ralf H, Wang, Yibo, Zhao, Fei, Körbelin, Jakob, Sun, Wenzhi, Wang, Yilong, Zhang, Hongqi, Hong, Tao, Ge, Woo-ping
Publicado 2023

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

por Yousef, Hanadie, Czupalla, Cathrin J., Lee, Davis, Chen, Michelle B., Burke, Ashley N., Zera, Kristy A., Zandstra, Judith, Berber, Elisabeth, Lehallier, Benoit, Mathur, Vidhu, Nair, Ramesh V., Bonanno, Liana N., Yang, Andrew C., Peterson, Todd, Hadeiba, Husein, Merkel, Taylor, Körbelin, Jakob, Schwaninger, Markus, Buckwalter, Marion S., Quake, Stephen R., Butcher, Eugene C., Wyss-Coray, Tony
Publicado 2019

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

por Alvarez-Vergara, Maria I., Rosales-Nieves, Alicia E., March-Diaz, Rosana, Rodriguez-Perinan, Guiomar, Lara-Ureña, Nieves, Ortega-de San Luis, Clara, Sanchez-Garcia, Manuel A., Martin-Bornez, Miguel, Gómez-Gálvez, Pedro, Vicente-Munuera, Pablo, Fernandez-Gomez, Beatriz, Marchena, Miguel A., Bullones-Bolanos, Andrea S., Davila, Jose C., Gonzalez-Martinez, Rocio, Trillo-Contreras, Jose L., Sanchez-Hidalgo, Ana C., del Toro, Raquel, Scholl, Francisco G., Herrera, Eloisa, Trepel, Martin, Körbelin, Jakob, Escudero, Luis M., Villadiego, Javier, Echevarria, Miriam, de Castro, Fernando, Gutierrez, Antonia, Rabano, Alberto, Vitorica, Javier, Pascual, Alberto
Publicado 2021

The SARS-CoV-2 main protease M(pro) causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

por Wenzel, Jan, Lampe, Josephine, Müller-Fielitz, Helge, Schuster, Raphael, Zille, Marietta, Müller, Kristin, Krohn, Markus, Körbelin, Jakob, Zhang, Linlin, Özorhan, Ümit, Neve, Vanessa, Wagner, Julian U. G., Bojkova, Denisa, Shumliakivska, Mariana, Jiang, Yun, Fähnrich, Anke, Ott, Fabian, Sencio, Valentin, Robil, Cyril, Pfefferle, Susanne, Sauve, Florent, Coêlho, Caio Fernando Ferreira, Franz, Jonas, Spiecker, Frauke, Lembrich, Beate, Binder, Sonja, Feller, Nina, König, Peter, Busch, Hauke, Collin, Ludovic, Villaseñor, Roberto, Jöhren, Olaf, Altmeppen, Hermann C., Pasparakis, Manolis, Dimmeler, Stefanie, Cinatl, Jindrich, Püschel, Klaus, Zelic, Matija, Ofengeim, Dimitry, Stadelmann, Christine, Trottein, François, Nogueiras, Ruben, Hilgenfeld, Rolf, Glatzel, Markus, Prevot, Vincent, Schwaninger, Markus
Publicado 2021