Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common C(H)2 cleavages in IgGs and IgG-like bispecific antibodies

por Cao, Mingyan, Jiao, Yang, Parthemore, Conner, Korman, Samuel, Ma, Jiao, Hunter, Alan, Kilby, Greg, Chen, Xiaoyu
Publicado 2021

Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis

por Cao, Mingyan, De Mel, Niluka, Jiao, Yang, Howard, James, Parthemore, Conner, Korman, Samuel, Thompson, Christopher, Wendeler, Michaela, Liu, Dengfeng
Publicado 2019

Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

por Cao, Mingyan, Hussmann, G. Patrick, Tao, Yeqing, O’Connor, Ellen, Parthemore, Conner, Zhang-Hulsey, Diana, Liu, Dengfeng, Jiao, Yang, de Mel, Niluka, Prophet, Meagan, Korman, Samuel, Sonawane, Jaytee, Grigoriadou, Christina, Huang, Yue, Umlauf, Scott, Chen, Xiaoyu
Publicado 2023