Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice

por Surendar, Jayagopi, Karunakaran, Indulekha, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model

por Specht, Sabine, Pfarr, Kenneth M., Arriens, Sandra, Hübner, Marc P., Klarmann-Schulz, Ute, Koschel, Marianne, Sternberg, Sonja, Martin, Coralie, Ford, Louise, Taylor, Mark J., Hoerauf, Achim
Publicado 2018

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system

por Risch, Frederic, Scheunemann, Johanna F., Reichwald, Julia J., Lenz, Benjamin, Ehrens, Alexandra, Gal, Joséphine, Fercoq, Frédéric, Koschel, Marianne, Fendler, Martina, Hoerauf, Achim, Martin, Coralie, Hübner, Marc P.
Publicado 2023

A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs

por Schlabe, Stefan, Korir, Patricia, Lämmer, Christine, Landmann, Frederic, Dubben, Bettina, Koschel, Marianne, Albers, Anna, Debrah, Linda Batsa, Debrah, Alexander Yaw, Hübner, Marc P., Pfarr, Kenneth, Klarmann-Schulz, Ute, Hoerauf, Achim
Publicado 2022

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

por Hübner, Marc P., Ehrens, Alexandra, Koschel, Marianne, Dubben, Bettina, Lenz, Franziska, Frohberger, Stefan J., Specht, Sabine, Quirynen, Ludo, Lachau-Durand, Sophie, Tekle, Fetene, Baeten, Benny, Engelen, Marc, Mackenzie, Charles D., Hoerauf, Achim
Publicado 2019

Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis

por Scheunemann, Johanna F., Risch, Frederic, Reichwald, Julia J., Lenz, Benjamin, Neumann, Anna-Lena, Garbe, Stephan, Frohberger, Stefan J., Koschel, Marianne, Ajendra, Jesuthas, Rothe, Maximilian, Latz, Eicke, Coch, Christoph, Hartmann, Gunther, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P.
Publicado 2023

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

por Hübner, Marc P., Martin, Coralie, Specht, Sabine, Koschel, Marianne, Dubben, Bettina, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Struever, Dominique, Mitre, Edward, Vallarino-Lhermitte, Nathaly, Gokool, Suzanne, Lustigman, Sara, Schneider, Manfred, Townson, Simon, Hoerauf, Achim, Scandale, Ivan
Publicado 2020

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

por Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., Pfarr, Kenneth, Kempf, Dale J., Hoerauf, Achim
Publicado 2019

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

por Ehrens, Alexandra, Lunde, Christopher S., Jacobs, Robert T., Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J., Lenz, Franziska, Fendler, Martina, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J., Freund, Yvonne R., Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J., Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

por Schiefer, Andrea, Hübner, Marc P., Krome, Anna, Lämmer, Christine, Ehrens, Alexandra, Aden, Tilman, Koschel, Marianne, Neufeld, Helene, Chaverra-Muñoz, Lillibeth, Jansen, Rolf, Kehraus, Stefan, König, Gabriele M., Pogorevc, Domen, Müller, Rolf, Stadler, Marc, Hüttel, Stephan, Hesterkamp, Thomas, Wagner, Karl, Pfarr, Kenneth, Hoerauf, Achim
Publicado 2020

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

por Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan
Publicado 2022

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

por Hawryluk, Natalie, Zhiru, Li, Carlow, Clotilde, Gokool, Suzanne, Townson, Simon, Kreiss, Tamara, Chojnowski, Agnieszka, Prorok, Monika, Siekierka, John, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Canan, Stacie, Khetani, Vikram, Zeldis, Jerome, Specht, Sabine, Hübner, Marc P., Scandale, Ivan
Publicado 2022

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

por von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Publicado 2019

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

por Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.
Publicado 2019

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

por Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2019