Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

por Takenaga, Keizo, Koshikawa, Nobuko, Nagase, Hiroki
Publicado 2021

Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model

por Takenaga, Keizo, Akimoto, Miho, Koshikawa, Nobuko, Nagase, Hiroki
Publicado 2020

Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice

por Takenaga, Keizo, Akimoto, Miho, Koshikawa, Nobuko, Nagase, Hiroki
Publicado 2021

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

por Koshikawa, Nobuko, Akimoto, Miho, Hayashi, Jun-Ichi, Nagase, Hiroki, Takenaga, Keizo
Publicado 2017

Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer

por Nagase, Hiroki, Watanabe, Takayoshi, Koshikawa, Nobuko, Yamamoto, Seigi, Takenaga, Keizo, Lin, Jason
Publicado 2021

MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target

por Takenaga, Keizo, Koshikawa, Nobuko, Akimoto, Miho, Tatsumi, Yasutoshi, Lin, Jason, Itami, Makiko, Nagase, Hiroki
Publicado 2021

A PI polyamide–TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation

por Koshikawa, Nobuko, Yasui, Nanami, Kida, Yuki, Shinozaki, Yoshinao, Tsuji, Kohei, Watanabe, Takayoshi, Takenaga, Keizo, Nagase, Hiroki
Publicado 2021

Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach

por Lin, Jason, Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Horton, Paul, Nagase, Hiroki
Publicado 2019

Suppression of non‐small‐cell lung cancer A549 tumor growth by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug

por Tsuji, Kohei, Kida, Yuki, Koshikawa, Nobuko, Yamamoto, Seigi, Shinozaki, Yoshinao, Watanabe, Takayoshi, Lin, Jason, Nagase, Hiroki, Takenaga, Keizo
Publicado 2022

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer

por Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Hiraoka, Kiriko, Inoue, Takahiro, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki
Publicado 2021

Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway

por Akimoto, Miho, Susa, Takao, Okudaira, Noriyuki, Koshikawa, Nobuko, Hisaki, Harumi, Iizuka, Masayoshi, Okinaga, Hiroko, Takenaga, Keizo, Okazaki, Tomoki, Tamamori-Adachi, Mimi
Publicado 2023

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma

por Tsujimoto, Akiko, Matsuo, Niina, Lai, Xiaoyi, Inoue, Takahiro, Yoda, Hiroyuki, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki
Publicado 2022

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome

por Lin, Jason, Hiraoka, Kiriko, Watanabe, Takayoshi, Kuo, Tony, Shinozaki, Yoshinao, Takatori, Atsushi, Koshikawa, Nobuko, Chandran, Anandhakumar, Otsuki, Joe, Sugiyama, Hiroshi, Horton, Paul, Nagase, Hiroki
Publicado 2016

Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

por Taniguchi, Masashi, Fujiwara, Kyoko, Nakai, Yuji, Ozaki, Toshinori, Koshikawa, Nobuko, Toshio, Kojima, Kataba, Motoaki, Oguni, Asako, Matsuda, Hiroyuki, Yoshida, Yukihiro, Tokuhashi, Yasuaki, Fukuda, Noboru, Ueno, Takahiro, Soma, Masayoshi, Nagase, Hiroki
Publicado 2014

Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation

por Mishra, Rajeev, Watanabe, Takayoshi, Kimura, Makoto T, Koshikawa, Nobuko, Ikeda, Maki, Uekusa, Shota, Kawashima, Hiroyuki, Wang, Xiaofei, Igarashi, Jun, Choudhury, Diptiman, Grandori, Carla, Kemp, Christopher J, Ohira, Miki, Verma, Narendra K, Kobayashi, Yujin, Takeuchi, Jin, Koshinaga, Tsugumichi, Nemoto, Norimichi, Fukuda, Noboru, Soma, Masayoshi, Kusafuka, Takeshi, Fujiwara, Kyoko, Nagase, Hiroki
Publicado 2015