Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles

por Ma, Qicheng, Chirn, Gung-Wei, Szustakowski, Joseph D, Bakhtiarova, Adel, Kosinski, Penelope A, Kemp, Daniel, Nirmala, Nanguneri
Publicado 2008

Dynamic resolution of functionally related gene sets in response to acute heat stress

por Szustakowski, Joseph D, Kosinski, Penelope A, Marrese, Christine A, Lee, Jee-Hyung, Elliman, Stephen J, Nirmala, Nanguneri, Kemp, Daniel M
Publicado 2007

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice

por Mattè, Alessandro, Kosinski, Penelope A., Federti, Enrica, Dang, Lenny, Recchiuti, Antonio, Russo, Roberta, Siciliano, Angela, Riccardi, Veronica, Janin, Anne, Mucci, Matteo, Leboeuf, Christophe, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia
Publicado 2023

AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad range...

por Rab, Minke A.E., van Oirschot, Brigitte A., Kosinski, Penelope A., Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, van Straaten, Stephanie, van Solinge, Wouter W., van Beers, Eduard J., Kung, Charles, van Wijk, Richard
Publicado 2020

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

por Garate, Zita, Quintana-Bustamante, Oscar, Crane, Ana M., Olivier, Emmanuel, Poirot, Laurent, Galetto, Roman, Kosinski, Penelope, Hill, Collin, Kung, Charles, Agirre, Xabi, Orman, Israel, Cerrato, Laura, Alberquilla, Omaira, Rodriguez-Fornes, Fatima, Fusaki, Noemi, Garcia-Sanchez, Felix, Maia, Tabita M., Ribeiro, Maria L., Sevilla, Julian, Prosper, Felipe, Jin, Shengfang, Mountford, Joanne, Guenechea, Guillermo, Gouble, Agnes, Bueren, Juan A., Davis, Brian R., Segovia, Jose C.
Publicado 2015