Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection

por Slezak, Tomasz, Kossiakoff, Anthony A.
Publicado 2021

Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme uptake

por Knejski, Paweł P., Erramilli, Satchal K., Kossiakoff, Anthony A.
Publicado 2023

Characterization of Engineered Actin Binding Proteins That Control Filament Assembly and Structure

por Brawley, Crista M., Uysal, Serdar, Kossiakoff, Anthony A., Rock, Ronald S.
Publicado 2010

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

por Rizk, Shahir S., Mukherjee, Somnath, Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A.
Publicado 2017

Engineering of a synthetic antibody fragment for structural and functional studies of K(+) channels

por Rohaim, Ahmed, Slezak, Tomasz, Koh, Young Hoon, Blachowicz, Lydia, Kossiakoff, Anthony A., Roux, Benoît
Publicado 2022

Allosteric Control of Ligand Binding Affinity Using Engineered Conformation-Specific Effector Proteins

por Rizk, Shahir S., Paduch, Marcin, Heithaus, John H., Duguid, Erica M., Sandstrom, Andrew, Kossiakoff, Anthony A.
Publicado 2011

Structure of human drug transporters OATP1B1 and OATP1B3

por Ciută, Anca-Denise, Nosol, Kamil, Kowal, Julia, Mukherjee, Somnath, Ramírez, Ana S., Stieger, Bruno, Kossiakoff, Anthony A., Locher, Kaspar P.
Publicado 2023

Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes

por Orlando, Benjamin J., Dominik, Pawel K., Roy, Sourav, Ogbu, Chinemerem P., Erramilli, Satchal K., Kossiakoff, Anthony A., Vecchio, Alex J.
Publicado 2022

Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling

por Rizk, Shahir S, Kouadio, Jean-Louis K, Szymborska, Anna, Duguid, Erica M, Mukherjee, Somnath, Zheng, Jiamao, Clevenger, Charles V, Kossiakoff, Anthony A
Publicado 2015

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel

por Feng, Peiqiang, Wu, Xudong, Erramilli, Satchal K., Paulo, Joao A., Knejski, Pawel, Gygi, Steven P., Kossiakoff, Anthony A., Rapoport, Tom A.
Publicado 2022

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

por Liu, Hongtao, Irobalieva, Rossitza N., Bang-Sørensen, Rose, Nosol, Kamil, Mukherjee, Somnath, Agrawal, Parth, Stieger, Bruno, Kossiakoff, Anthony A., Locher, Kaspar P.
Publicado 2022

ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

por Chen, Qiuyan, Schafer, Christopher T., Mukherjee, Somnath, Gustavsson, Martin, Agrawal, Parth, Yao, Xin-Qiu, Kossiakoff, Anthony A., Handel, Tracy M., Tesmer, John J. G.
Publicado 2023

Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

por Kordon, Szymon P., Dutka, Przemysław, Adamska, Justyna M., Bandekar, Sumit J., Leon, Katherine, Erramilli, Satchal K., Adams, Brock, Li, Jingxian, Kossiakoff, Anthony A., Araç, Demet
Publicado 2023

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

por Koldobskaya, Yelena, Duguid, Erica M., Shechner, David M., Suslov, Nikolai B., Ye, Jingdong, Sidhu, Sachdev S., Bartel, David P., Koide, Shohei, Kossiakoff, Anthony A., Piccirilli, Joseph A.
Publicado 2010

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

por Tsutsumi, Naotaka, Mukherjee, Somnath, Waghray, Deepa, Janda, Claudia Y, Jude, Kevin M, Miao, Yi, Burg, John S, Aduri, Nanda Gowtham, Kossiakoff, Anthony A, Gati, Cornelius, Garcia, K Christopher
Publicado 2020

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias

por Yen, Yu-Chen, Schafer, Christopher T., Gustavsson, Martin, Eberle, Stefanie A., Dominik, Pawel K., Deneka, Dawid, Zhang, Penglie, Schall, Thomas J., Kossiakoff, Anthony A., Tesmer, John J. G., Handel, Tracy M.
Publicado 2022

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

por Bloch, Joël S., John, Alan, Mao, Runyu, Mukherjee, Somnath, Boilevin, Jérémy, Irobalieva, Rossitza N., Darbre, Tamis, Scott, Nichollas E., Reymond, Jean-Louis, Kossiakoff, Anthony A., Goddard-Borger, Ethan D., Locher, Kaspar P.
Publicado 2023

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers

por Lim, Shion A., Zhou, Jie, Martinko, Alexander J., Wang, Yung-Hua, Filippova, Ekaterina V., Steri, Veronica, Wang, Donghui, Remesh, Soumya G., Liu, Jia, Hann, Byron, Kossiakoff, Anthony A., Evans, Michael J., Leung, Kevin K., Wells, James A.
Publicado 2022

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

por Mukherjee, Somnath, Erramilli, Satchal K., Ammirati, Mark, Alvarez, Frances J. D., Fennell, Kimberly F., Purdy, Michael D., Skrobek, Blazej M., Radziwon, Katarzyna, Coukos, John, Kang, Yanyong, Dutka, Przemysław, Gao, Xiang, Qiu, Xiayang, Yeager, Mark, Eric Xu, H., Han, Seungil, Kossiakoff, Anthony A.
Publicado 2020

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

por Leonhardt, Susan A., Purdy, Michael D., Grover, Jonathan R., Yang, Ziwei, Poulos, Sandra, McIntire, William E., Tatham, Elizabeth A., Erramilli, Satchal K., Nosol, Kamil, Lai, Kin Kui, Ding, Shilei, Lu, Maolin, Uchil, Pradeep D., Finzi, Andrés, Rein, Alan, Kossiakoff, Anthony A., Mothes, Walther, Yeager, Mark
Publicado 2023