Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding

por Müller, Christine, Zidek, Laura M, Eichwald, Sabrina, Kortman, Gertrud, Koster, Mirjam H, Calkhoven, Cornelis F
Publicado 2022

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

por Schukken, Klaske M., Zhu, Yinan, Bakker, Petra L., Koster, Mirjam H., Harkema, Liesbeth, Youssef, Sameh A., de Bruin, Alain, Foijer, Floris
Publicado 2021

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

por Moreno, Eva, Toussaint, Mathilda J.M., van Essen, Saskia C., Bongiovanni, Laura, van Liere, Elsbeth A., Koster, Mirjam H., Yuan, Ruixue, van Deursen, Jan M., Westendorp, Bart, de Bruin, Alain
Publicado 2021

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

por Dommerholt, Marleen B., Blankestijn, Maaike, Vieira‐Lara, Marcel A., van Dijk, Theo H., Wolters, Henk, Koster, Mirjam H., Gerding, Albert, van Os, Ronald P., Bloks, Vincent W., Bakker, Barbara M., Kruit, Janine K., Jonker, Johan W.
Publicado 2020

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

por La Rose, Anouk M., Groenen, Anouk G., Halmos, Benedek, Bazioti, Venetia, Rutten, Martijn G.S., Krishnamurthy, Kishore A., Koster, Mirjam H., Kloosterhuis, Niels J., Smit, Marieke, Havinga, Rick, Mithieux, Gilles, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H., Westerterp, Marit
Publicado 2022

The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis

por Heida, Andries, Gruben, Nanda, Catrysse, Leen, Koehorst, Martijn, Koster, Mirjam, Kloosterhuis, Niels J., Gerding, Albert, Havinga, Rick, Bloks, Vincent W., Bongiovanni, Laura, Wolters, Justina C., van Dijk, Theo, van Loo, Geert, de Bruin, Alain, Kuipers, Folkert, Koonen, Debby P.Y., van de Sluis, Bart
Publicado 2021

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR‐associated protein 9–Mediated Gene Editing

por Rutten, Martijn G.S., Derks, Terry G.J., Huijkman, Nicolette C.A., Bos, Trijnie, Kloosterhuis, Niels J., van de Kolk, Kees C.W.A., Wolters, Justina C., Koster, Mirjam H., Bongiovanni, Laura, Thomas, Rachel E., de Bruin, Alain, van de Sluis, Bart, Oosterveer, Maaike H.
Publicado 2021

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19(+)- liver cells deficient for p53 and Rb

por Matondo, Ramadhan B, Toussaint, Mathilda JM, Govaert, Klaas M, van Vuuren, Luciel D, Nantasanti, Sathidpak, Nijkamp, Maarten W, Pandit, Shusil K, Tooten, Peter CJ, Koster, Mirjam H, Holleman, Kaylee, Schot, Arend, Gu, Guoqiang, Spee, Bart, Roskams, Tania, Rinkes, Inne Borel, Schotanus, Baukje, Kranenburg, Onno, de Bruin, Alain
Publicado 2016

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet

por Ronda, Onne A. H. O., van de Heijning, Bert J. M., de Bruin, Alain, Thomas, Rachel E., Martini, Ingrid, Koehorst, Martijn, Gerding, Albert, Koster, Mirjam H., Bloks, Vincent W., Jurdzinski, Angelika, Mulder, Niels L., Havinga, Rick, van der Beek, Eline M., Reijngoud, Dirk-Jan, Kuipers, Folkert, Verkade, Henkjan J.
Publicado 2020

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

por Rutten, Martijn G. S., Lei, Yu, Hoogerland, Joanne H., Bloks, Vincent W., Yang, Hong, Bos, Trijnie, Krishnamurthy, Kishore A., Bleeker, Aycha, Koster, Mirjam H., Thomas, Rachel E., Wolters, Justina C., van den Bos, Hilda, Mithieux, Gilles, Rajas, Fabienne, Mardinoglu, Adil, Spierings, Diana C. J., de Bruin, Alain, van de Sluis, Bart, Oosterveer, Maaike H.
Publicado 2023

Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

por Loaiza, Natalia, Hartgers, Merel L., Reeskamp, Laurens F., Balder, Jan-Willem, Rimbert, Antoine, Bazioti, Venetia, Wolters, Justina C., Winkelmeijer, Maaike, Jansen, Hans P.G., Dallinga-Thie, Geesje M., Volta, Andrea, Huijkman, Nicolette, Smit, Marieke, Kloosterhuis, Niels, Koster, Mirjam, Svendsen, Arthur F., van de Sluis, Bart, Hovingh, G. Kees, Grefhorst, Aldo, Kuivenhoven, Jan Albert
Publicado 2020

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

por Brandsma, Eelke, Kloosterhuis, Niels J., Koster, Mirjam, Dekker, Daphne C., Gijbels, Marion J.J., van der Velden, Saskia, Ríos-Morales, Melany, van Faassen, Martijn J.R., Loreti, Marco G., de Bruin, Alain, Fu, Jingyuan, Kuipers, Folkert, Bakker, Barbara M., Westerterp, Marit, de Winther, Menno P.J., Hofker, Marten H., van de Sluis, Bart, Koonen, Debby P.Y.
Publicado 2019

Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

por Stroo, Esther, Janssen, Leen, Sin, Olga, Hogewerf, Wytse, Koster, Mirjam, Harkema, Liesbeth, Youssef, Sameh A, Beschorner, Natalie, Wolters, Anouk HG, Bakker, Bjorn, Becker, Lore, Garrett, Lilian, Marschall, Susan, Hoelter, Sabine M, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Thathiah, Amantha, Foijer, Floris, van de Sluis, Bart, van Deursen, Jan, Jucker, Matthias, de Bruin, Alain, Nollen, Ellen AA
Publicado 2023

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

por Bazioti, Venetia, La Rose, Anouk M., Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G., Marmolejo-Garza, Alejandro, Koster, Mirjam H., Kloosterhuis, Niels J., Havinga, Rick, Pranger, Alle T., Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B., Yvan-Charvet, Laurent, van den Bogaart, Geert, Westerterp, Marit
Publicado 2022

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

por van Zwol, Willemien, Rimbert, Antoine, Wolters, Justina C., Smit, Marieke, Bloks, Vincent W., Kloosterhuis, Niels J., Huijkman, Nicolette C. A., Koster, Mirjam H., Tharehalli, Umesh, de Neck, Simon M., Bournez, Colin, Fuh, Marceline M., Kuipers, Jeroen, Rajan, Sujith, de Bruin, Alain, Ginsberg, Henry N., van Westen, Gerard J. P., Hussain, M. Mahmood, Scheja, Ludger, Heeren, Joerg, Zimmerman, Philip, van de Sluis, Bart, Kuivenhoven, Jan Albert
Publicado 2023

Rebalancing of mitochondrial homeostasis through an NAD(+)-SIRT1 pathway preserves intestinal barrier function in severe malnutrition

por Ling, Catriona, Versloot, Christian J., Arvidsson Kvissberg, Matilda E., Hu, Guanlan, Swain, Nathan, Horcas-Nieto, José M., Miraglia, Emily, Thind, Mehakpreet K., Farooqui, Amber, Gerding, Albert, van Eunen, Karen, Koster, Mirjam H., Kloosterhuis, Niels J., Chi, Lijun, ChenMi, YueYing, Langelaar-Makkinje, Miriam, Bourdon, Celine, Swann, Jonathan, Smit, Marieke, de Bruin, Alain, Youssef, Sameh A., Feenstra, Marjon, van Dijk, Theo H., Thedieck, Kathrin, Jonker, Johan W., Kim, Peter K., Bakker, Barbara M., Bandsma, Robert H.J.
Publicado 2023