Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

por McDaniel, Margaret M., Kottyan, Leah C., Singh, Harinder, Pasare, Chandrashekhar
Publicado 2020

Frontotemporal degeneration genetic risk loci and transcription regulation as a possible mechanistic link to disease risk

por Sawyer, Russell P., Stone, Hillarey K., Salim, Hanan, Lu, Xiaoming, Weirauch, Matthew T., Kottyan, Leah
Publicado 2022

Gene–environment interactions and their impact on human health

por Virolainen, Samuel J., VonHandorf, Andrew, Viel, Kenyatta C. M. F., Weirauch, Matthew T., Kottyan, Leah C.
Publicado 2022

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

por Hass, Matthew R., Brissette, Daniel, Parameswaran, Sreeja, Pujato, Mario, Donmez, Omer, Kottyan, Leah C., Weirauch, Matthew T., Kopan, Raphael
Publicado 2021

Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes

por Kottyan, Leah C, Woo, Jessica G, Keddache, Mehdi, Banach, Walter, Crimmins, Nancy A, Dolan, Lawrence M, Martin, Lisa J
Publicado 2012

DNA repair in lupus

por Xu, Jiadi, Patel, Zubin, Kottyan, Leah, Gatti, Richard A, McCurdy, Deborah K, Kaufman, Kenneth M, Harley, John B
Publicado 2014

Comprehensive Review of Steroid-Sensitive Nephrotic Syndrome Genetic Risk Loci and Transcriptional Regulation as a Possible Mechanistic Link to Disease Risk

por Stone, Hillarey K., Parameswaran, Sreeja, Eapen, Amy A., Chen, Xiaoting, Harley, John B., Devarajan, Prasad, Weirauch, Matthew T., Kottyan, Leah
Publicado 2020

After the Infection: A Survey of Pathogens and Non-communicable Human Disease

por Lape, Michael, Schnell, Daniel, Parameswaran, Sreeja, Ernst, Kevin, Salomonis, Nathan, Martin, Lisa J., Harnett, Brett M., Kottyan, Leah C., Weirauch, Matthew T.
Publicado 2023

4277 Functional consequences of the juvenile idiopathic arthritis risk variant at 1q24.3

por Moncrieffe, Halima, Dunn, Katelyn, Huang, Yongbo, Chen, Xiaoting, Langefeld, Carl D., Weirauch, Matthew T., Harley, John B., Kottyan, Leah C., Thompson, Susan D.
Publicado 2020

Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis

por Arumugam, Muthuvel, Ahrens, Richard, Osterfeld, Heather, Kottyan, Leah C, Shang, Xun, Maclennan, John A, Zimmermann, Nives, Zheng, Yi, Finkelman, Fred D, Hogan, Simon P
Publicado 2011

On family-based genome-wide association studies with large pedigrees: observations and recommendations

por Fardo, David W, Zhang, Xue, Ding, Lili, He, Hua, Kurowski, Brad, Alexander, Eileen S, Mersha, Tesfaye B, Pilipenko, Valentina, Kottyan, Leah, Nandakumar, Kannabiran, Martin, Lisa
Publicado 2014

Modeling of multivariate longitudinal phenotypes in family genetic studies with Bayesian multiplicity adjustment

por Ding, Lili, Kurowski, Brad G, He, Hua, Alexander, Eileen S, Mersha, Tesfaye B, Fardo, David W, Zhang, Xue, Pilipenko, Valentina V, Kottyan, Leah, Martin, Lisa J
Publicado 2014

Using Mendelian inheritance errors as quality control criteria in whole genome sequencing data set

por Pilipenko, Valentina V, He, Hua, Kurowski, Brad G, Alexander, Eileen S, Zhang, Xue, Ding, Lili, Mersha , Tesfaye B, Kottyan, Leah, Fardo, David W, Martin, Lisa J
Publicado 2014

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population

por Namjou, Bahram, Ni, Yizhao, Harley, Isaac T. W., Chepelev, Iouri, Cobb, Beth, Kottyan, Leah C., Gaffney, Patrick M., Guthridge, Joel M., Kaufman, Kenneth, Harley, John B.
Publicado 2014

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

por Bray, David, Hook, Heather, Zhao, Rose, Keenan, Jessica L., Penvose, Ashley, Osayame, Yemi, Mohaghegh, Nima, Chen, Xiaoting, Parameswaran, Sreeja, Kottyan, Leah C., Weirauch, Matthew T., Siggers, Trevor
Publicado 2022

Whole blood transcriptomics identifies gene expression associated with peanut allergy in infants at high risk

por Devonshire, Ashley L., Fan, Hanli, Pujato, Mario, Paranjpe, Aditi, Gursel, Demirkan, Schipma, Matthew, Dunn, Julia M., Andorf, Sandra, Pongracic, Jacqueline A., Kottyan, Leah C., Kumar, Rajesh
Publicado 2021

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

por Meibers, Hannah E., Warrick, Kathrynne A., VonHandorf, Andrew, Vallez, Charles N., Kawarizadeh, Kiana, Saha, Irene, Donmez, Omer, Jain, Viral G., Kottyan, Leah C., Weirauch, Matthew T., Pasare, Chandrashekhar
Publicado 2023

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

por Harley, John B., Chen, Xiaoting, Pujato, Mario, Miller, Daniel, Maddox, Avery, Forney, Carmy, Magnusen, Albert F., Lynch, Arthur, Chetal, Kashish, Yukawa, Masashi, Barski, Artem, Salomonis, Nathan, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T.
Publicado 2018

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

por Wang, Li, Rossi, Robert M., Chen, Xiaoting, Chen, Jing, Runyon, Jilian, Chawla, Mehak, Miller, Daniel, Forney, Carmy, Lynch, Arthur, Zhang, Xuzhe, Kong, Fansheng, Jacobsson, Bo, Kottyan, Leah C., Weirauch, Matthew T., Zhang, Ge, Muglia, Louis J.
Publicado 2023

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

por Song, Ran, Gao, Yajing, Dozmorov, Igor, Malladi, Venkat, Saha, Irene, McDaniel, Margaret M., Parameswaran, Sreeja, Liang, Chaoying, Arana, Carlos, Zhang, Bo, Wakeland, Benjamin, Zhou, Jinchun, Weirauch, Matthew T., Kottyan, Leah C., Wakeland, Edward K., Pasare, Chandrashekhar
Publicado 2021