Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

por McDaniel, Margaret M., Kottyan, Leah C., Singh, Harinder, Pasare, Chandrashekhar
Publicado 2020

Gene–environment interactions and their impact on human health

por Virolainen, Samuel J., VonHandorf, Andrew, Viel, Kenyatta C. M. F., Weirauch, Matthew T., Kottyan, Leah C.
Publicado 2022

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

por Hass, Matthew R., Brissette, Daniel, Parameswaran, Sreeja, Pujato, Mario, Donmez, Omer, Kottyan, Leah C., Weirauch, Matthew T., Kopan, Raphael
Publicado 2021

Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes

por Kottyan, Leah C, Woo, Jessica G, Keddache, Mehdi, Banach, Walter, Crimmins, Nancy A, Dolan, Lawrence M, Martin, Lisa J
Publicado 2012

After the Infection: A Survey of Pathogens and Non-communicable Human Disease

por Lape, Michael, Schnell, Daniel, Parameswaran, Sreeja, Ernst, Kevin, Salomonis, Nathan, Martin, Lisa J., Harnett, Brett M., Kottyan, Leah C., Weirauch, Matthew T.
Publicado 2023

4277 Functional consequences of the juvenile idiopathic arthritis risk variant at 1q24.3

por Moncrieffe, Halima, Dunn, Katelyn, Huang, Yongbo, Chen, Xiaoting, Langefeld, Carl D., Weirauch, Matthew T., Harley, John B., Kottyan, Leah C., Thompson, Susan D.
Publicado 2020

Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis

por Arumugam, Muthuvel, Ahrens, Richard, Osterfeld, Heather, Kottyan, Leah C, Shang, Xun, Maclennan, John A, Zimmermann, Nives, Zheng, Yi, Finkelman, Fred D, Hogan, Simon P
Publicado 2011

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population

por Namjou, Bahram, Ni, Yizhao, Harley, Isaac T. W., Chepelev, Iouri, Cobb, Beth, Kottyan, Leah C., Gaffney, Patrick M., Guthridge, Joel M., Kaufman, Kenneth, Harley, John B.
Publicado 2014

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

por Bray, David, Hook, Heather, Zhao, Rose, Keenan, Jessica L., Penvose, Ashley, Osayame, Yemi, Mohaghegh, Nima, Chen, Xiaoting, Parameswaran, Sreeja, Kottyan, Leah C., Weirauch, Matthew T., Siggers, Trevor
Publicado 2022

Whole blood transcriptomics identifies gene expression associated with peanut allergy in infants at high risk

por Devonshire, Ashley L., Fan, Hanli, Pujato, Mario, Paranjpe, Aditi, Gursel, Demirkan, Schipma, Matthew, Dunn, Julia M., Andorf, Sandra, Pongracic, Jacqueline A., Kottyan, Leah C., Kumar, Rajesh
Publicado 2021

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

por Meibers, Hannah E., Warrick, Kathrynne A., VonHandorf, Andrew, Vallez, Charles N., Kawarizadeh, Kiana, Saha, Irene, Donmez, Omer, Jain, Viral G., Kottyan, Leah C., Weirauch, Matthew T., Pasare, Chandrashekhar
Publicado 2023

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

por Harley, John B., Chen, Xiaoting, Pujato, Mario, Miller, Daniel, Maddox, Avery, Forney, Carmy, Magnusen, Albert F., Lynch, Arthur, Chetal, Kashish, Yukawa, Masashi, Barski, Artem, Salomonis, Nathan, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T.
Publicado 2018

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

por Wang, Li, Rossi, Robert M., Chen, Xiaoting, Chen, Jing, Runyon, Jilian, Chawla, Mehak, Miller, Daniel, Forney, Carmy, Lynch, Arthur, Zhang, Xuzhe, Kong, Fansheng, Jacobsson, Bo, Kottyan, Leah C., Weirauch, Matthew T., Zhang, Ge, Muglia, Louis J.
Publicado 2023

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

por Song, Ran, Gao, Yajing, Dozmorov, Igor, Malladi, Venkat, Saha, Irene, McDaniel, Margaret M., Parameswaran, Sreeja, Liang, Chaoying, Arana, Carlos, Zhang, Bo, Wakeland, Benjamin, Zhou, Jinchun, Weirauch, Matthew T., Kottyan, Leah C., Wakeland, Edward K., Pasare, Chandrashekhar
Publicado 2021

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

por Reighard, Seth D., Cranert, Stacey A., Rangel, Kelly M., Ali, Ayad, Gyurova, Ivayla E., de la Cruz-Lynch, Arthur T., Tuazon, Jasmine A., Khodoun, Marat V., Kottyan, Leah C., Smith, David F., Brunner, Hermine I., Waggoner, Stephen N.
Publicado 2020

maxATAC: Genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

por Cazares, Tareian A., Rizvi, Faiz W., Iyer, Balaji, Chen, Xiaoting, Kotliar, Michael, Bejjani, Anthony T., Wayman, Joseph A., Donmez, Omer, Wronowski, Benjamin, Parameswaran, Sreeja, Kottyan, Leah C., Barski, Artem, Weirauch, Matthew T., Prasath, V. B. Surya, Miraldi, Emily R.
Publicado 2023

Global discovery of lupus genetic risk variant allelic enhancer activity

por Lu, Xiaoming, Chen, Xiaoting, Forney, Carmy, Donmez, Omer, Miller, Daniel, Parameswaran, Sreeja, Hong, Ted, Huang, Yongbo, Pujato, Mario, Cazares, Tareian, Miraldi, Emily R., Ray, John P., de Boer, Carl G., Harley, John B., Weirauch, Matthew T., Kottyan, Leah C.
Publicado 2021

Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci

por Hong, Ted, Parameswaran, Sreeja, Donmez, Omer A., Miller, Daniel, Forney, Carmy, Lape, Michael, Saint Just Ribeiro, Mariana, Liang, Jun, Edsall, Lee E., Magnusen, Albert F., Miller, William, Chepelev, Iouri, Harley, John B., Zhao, Bo, Kottyan, Leah C., Weirauch, Matthew T.
Publicado 2021

The struggle to find reliable results in exome sequencing data: filtering out Mendelian errors

por Patel, Zubin H., Kottyan, Leah C., Lazaro, Sara, Williams, Marc S., Ledbetter, David H., Tromp, hbGerard, Rupert, Andrew, Kohram, Mojtaba, Wagner, Michael, Husami, Ammar, Qian, Yaping, Valencia, C. Alexander, Zhang, Kejian, Hostetter, Margaret K., Harley, John B., Kaufman, Kenneth M.
Publicado 2014

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis

por Namjou, Bahram, Marsolo, Keith, Caroll, Robert J., Denny, Joshua C., Ritchie, Marylyn D., Verma, Shefali S., Lingren, Todd, Porollo, Aleksey, Cobb, Beth L., Perry, Cassandra, Kottyan, Leah C., Rothenberg, Marc E., Thompson, Susan D., Holm, Ingrid A., Kohane, Isaac S., Harley, John B.
Publicado 2014