Age and Geographical Distribution in Families with BRCA1/BRCA2 Mutations in the Slovak Republic

por Ciernikova, Sona, Tomka, Miroslav, Kovac, Michal, Stevurkova, Viola, Zajac, Vladimir
Publicado 2006

Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics

por Engert, Florian, Kovac, Michal, Baumhoer, Daniel, Nathrath, Michaela, Fulda, Simone
Publicado 2016

Osteosarcoma of the Mandible in a Patient with Florid Cemento-Osseous Dysplasia and Li–Fraumeni Syndrome: A Rare Coincidence

por Haefliger, Simon, Harder, Dorothee, Kovac, Michal, Linkeschova, Karin, Eufinger, Harald, Baumhoer, Daniel
Publicado 2020

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

por Ameline, Baptiste, Kovac, Michal, Nathrath, Michaela, Barenboim, Maxim, Witt, Olaf, Krieg, Andreas H, Baumhoer, Daniel
Publicado 2020

DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma

por Barenboim, Maxim, Kovac, Michal, Ameline, Baptiste, Jones, David T. W., Witt, Olaf, Bielack, Stefan, Burdach, Stefan, Baumhoer, Daniel, Nathrath, Michaela
Publicado 2021

NTRK fusions in osteosarcoma are rare and non‐functional events

por Ameline, Baptiste, Saba, Karim H, Kovac, Michal, Magnusson, Linda, Witt, Olaf, Bielack, Stefan, Nathrath, Michaela, Nord, Karolin H, Baumhoer, Daniel
Publicado 2020

Expression of OCT4 isoforms is reduced in primary colorectal cancer

por Turyova, Eva, Mikolajcik, Peter, Grendar, Marian, Kudelova, Eva, Holubekova, Veronika, Kalman, Michal, Marcinek, Juraj, Hrnciar, Matej, Kovac, Michal, Miklusica, Juraj, Laca, Ludovit, Lasabova, Zora
Publicado 2023

Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma

por Lackner, Carolin, Quagliata, Luca, Cross, William, Ribi, Sebastian, Heinimann, Karl, Paradiso, Viola, Quintavalle, Cristina, Kovacova, Monika, Baumhoer, Daniel, Piscuoglio, Salvatore, Terracciano, Luigi, Kovac, Michal
Publicado 2019

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies

por Kovac, Michal, Ameline, Baptiste, Ribi, Sebastian, Kovacova, Monika, Cross, William, Barenboim, Maxim, Witt, Olaf, Bielack, Stefan, Krieg, Andreas, Hartmann, Wolfgang, Nathrath, Michaela, Baumhoer, Daniel
Publicado 2021

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary patient‐derived osteosarcoma cells and synergizes with cisplatin and talazoparib

por Heidler, Christopher L., Roth, Eva K., Thiemann, Markus, Blattmann, Claudia, Perez, Ramon L., Huber, Peter E., Kovac, Michal, Amthor, Beate, Neu‐Yilik, Gabriele, Kulozik, Andreas E.
Publicado 2019

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation

por Pinheiro, Manuela, Pinto, Carla, Peixoto, Ana, Veiga, Isabel, Lopes, Paula, Henrique, Rui, Baldaia, Helena, Carneiro, Fátima, Seruca, Raquel, Tomlinson, Ian, Kovac, Michal, Heinimann, Karl, Teixeira, Manuel R
Publicado 2015

Loss of NF2 defines a genetic subgroup of non‐FOS‐rearranged osteoblastoma

por Saba, Karim H, Cornmark, Louise, Hofvander, Jakob, Magnusson, Linda, Nilsson, Jenny, van den Bos, Hilda, Spierings, Diana CJ, Foijer, Floris, Staaf, Johan, Brosjö, Otte, Sumathi, Vaiyapuri P, Lam, Suk Wai, Szuhai, Karoly, Bovée, Judith VMG, Kovac, Michal, Baumhoer, Daniel, Styring, Emelie, Nord, Karolin H
Publicado 2020

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

por Findlay, John M., Castro-Giner, Francesc, Makino, Seiko, Rayner, Emily, Kartsonaki, Christiana, Cross, William, Kovac, Michal, Ulahannan, Danny, Palles, Claire, Gillies, Richard S., MacGregor, Thomas P., Church, David, Maynard, Nicholas D., Buffa, Francesca, Cazier, Jean-Baptiste, Graham, Trevor A., Wang, Lai-Mun, Sharma, Ricky A., Middleton, Mark, Tomlinson, Ian
Publicado 2016

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

por López-García, Carlos, Sansregret, Laurent, Domingo, Enric, McGranahan, Nicholas, Hobor, Sebastijan, Birkbak, Nicolai Juul, Horswell, Stuart, Grönroos, Eva, Favero, Francesco, Rowan, Andrew J., Matthews, Nicholas, Begum, Sharmin, Phillimore, Benjamin, Burrell, Rebecca, Oukrif, Dahmane, Spencer-Dene, Bradley, Kovac, Michal, Stamp, Gordon, Stewart, Aengus, Danielsen, Havard, Novelli, Marco, Tomlinson, Ian, Swanton, Charles
Publicado 2017

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

por Kovac, Michal, Blattmann, Claudia, Ribi, Sebastian, Smida, Jan, Mueller, Nikola S., Engert, Florian, Castro-Giner, Francesc, Weischenfeldt, Joachim, Kovacova, Monika, Krieg, Andreas, Andreou, Dimosthenis, Tunn, Per-Ulf, Dürr, Hans Roland, Rechl, Hans, Schaser, Klaus-Dieter, Melcher, Ingo, Burdach, Stefan, Kulozik, Andreas, Specht, Katja, Heinimann, Karl, Fulda, Simone, Bielack, Stefan, Jundt, Gernot, Tomlinson, Ian, Korbel, Jan O., Nathrath, Michaela, Baumhoer, Daniel
Publicado 2015

The evolutionary landscape of colorectal tumorigenesis

por Cross, William, Kovac, Michal, Mustonen, Ville, Temko, Daniel, Davis, Hayley, Baker, Ann-Marie, Biswas, Sujata, Arnold, Roland, Chegwidden, Laura, Gatenbee, Chandler, Anderson, Alexander R, Koelzer, Viktor H, Martinez, Pierre, Jiang, Xiaowei, Domingo, Enric, Woodcock, Dan, Feng, Yun, Kovacova, Monika, Maughan, Tim, Jansen, Marnix, Rodriguez-Justo, Manuel, Ashraf, Shazad, Guy, Richard, Cunningham, Christopher, East, James E, Wedge, David C, Wang, Lai Mun, Palles, Claire, Heinimann, Karl, Sottoriva, Andrea, Leedham, Simon J, Graham, Trevor A, Tomlinson, Ian PM
Publicado 2018

Germline mutations in the proof-reading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

por Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M., Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Almeida, Estrella Guarino, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J., Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw JW, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian
Publicado 2012

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

por Kovac, Michal, Navas, Carolina, Horswell, Stuart, Salm, Max, Bardella, Chiara, Rowan, Andrew, Stares, Mark, Castro-Giner, Francesc, Fisher, Rosalie, de Bruin, Elza C., Kovacova, Monika, Gorman, Maggie, Makino, Seiko, Williams, Jennet, Jaeger, Emma, Jones, Angela, Howarth, Kimberley, Larkin, James, Pickering, Lisa, Gore, Martin, Nicol, David L., Hazell, Steven, Stamp, Gordon, O’Brien, Tim, Challacombe, Ben, Matthews, Nik, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Varela, Ignacio, Chandra, Ashish, Horsfield, Catherine, Polson, Alexander, Tran, Maxine, Bhatt, Rupesh, Terracciano, Luigi, Eppenberger-Castori, Serenella, Protheroe, Andrew, Maher, Eamonn, El Bahrawy, Mona, Fleming, Stewart, Ratcliffe, Peter, Heinimann, Karl, Swanton, Charles, Tomlinson, Ian
Publicado 2015

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

por Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M., Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P., Kovac, Michal, Adams, Claire L., Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J., Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Bird, Nigel C., Hardie, Laura J., Reid, Brian J., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Casson, Alan G., Fitzgerald, Rebecca, Whiteman, David C., Risch, Harvey A., Levine, David M., Vaughan, Tom L., Verhaar, Auke P., van den Brande, Jan, Toxopeus, Eelke L., Spaander, Manon C., Wijnhoven, Bas P.L., van der Laan, Luc J.W., Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V., O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A., Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, Jankowski, Janusz
Publicado 2015