New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer...

por Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Yu., Rudakova, Elena V., Proshin, Alexey N., Serkov, Igor V., Radchenko, Eugene V., Palyulin, Vladimir A., Bachurin, Sergey O., Richardson, Rudy J.
Publicado 2020

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease

por Grishchenko, Maria V., Makhaeva, Galina F., Burgart, Yanina V., Rudakova, Elena V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Astakhova, Tatiana Y., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Richardson, Rudy J., Saloutin, Victor I.
Publicado 2022

Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases

por Bachurin, Sergey O., Makhaeva, Galina F., Shevtsova, Elena F., Boltneva, Natalia P., Kovaleva, Nadezhda V., Lushchekina, Sofya V., Rudakova, Elena V., Dubova, Ludmila G., Vinogradova, Daria V., Sokolov, Vladimir B., Aksinenko, Alexey Yu., Fisenko, Vladimir P., Richardson, Rudy J., Aliev, Gjumrakch
Publicado 2019

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

por Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Rudakova, Elena V., Lushchekina, Sofya V., Astakhova, Tatiana Yu., Serkov, Igor V., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Korabecny, Jan, Soukup, Ondrej, Bachurin, Sergey O., Richardson, Rudy J.
Publicado 2022

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

por Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Lushchekina, Sofya V., Faingold, Irina I., Poletaeva, Darya A., Soldatova, Yuliya V., Kotelnikova, Raisa A., Serkov, Igor V., Ustinov, Anatoly K., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Richardson, Rudy J.
Publicado 2020

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity

por Burgart, Yanina V., Makhaeva, Galina F., Krasnykh, Olga P., Borisevich, Sophia S., Agafonova, Natalia A., Kovaleva, Nadezhda V., Boltneva, Natalia P., Rudakova, Elena V., Shchegolkov, Evgeny V., Triandafilova, Galina A., Gazizov, Denis A., Serebryakova, Olga G., Ulitko, Maria V., Khursan, Sergey L., Saloutin, Victor I., Richardson, Rudy J.
Publicado 2022

New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones

por Elkina, Natalia A., Grishchenko, Maria V., Shchegolkov, Evgeny V., Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Y., Radchenko, Eugene V., Palyulin, Vladimir A., Zhilina, Ekaterina F., Perminova, Anastasiya N., Lapshin, Luka S., Burgart, Yanina V., Saloutin, Victor I., Richardson, Rudy J.
Publicado 2022

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment

por Bachurin, Sergey O., Shevtsova, Elena F., Makhaeva, Galina F., Grigoriev, Vladimir V., Boltneva, Natalia P., Kovaleva, Nadezhda V., Lushchekina, Sofya V., Shevtsov, Pavel N., Neganova, Margarita E., Redkozubova, Olga M., Bovina, Elena V., Gabrelyan, Alexey V., Fisenko, Vladimir P., Sokolov, Vladimir B., Aksinenko, Alexey Yu, Echeverria, Valentina, Barreto, George E., Aliev, Gjumrakch
Publicado 2017

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System

por Akimov, Mikhail G., Kudryavtsev, Denis S., Kryukova, Elena V., Fomina-Ageeva, Elena V., Zakharov, Stanislav S., Gretskaya, Natalia M., Zinchenko, Galina N., Serkov, Igor V., Makhaeva, Galina F., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Palikov, Victor A., Palikova, Yulia, Dyachenko, Igor A., Kasheverov, Igor E., Tsetlin, Victor I., Bezuglov, Vladimir V.
Publicado 2020

Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease

por Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Grishchenko, Maria V., Lushchekina, Sofya V., Astakhova, Tatiana Y., Serebryakova, Olga G., Timokhina, Elena N., Zhilina, Ekaterina F., Shchegolkov, Evgeny V., Ulitko, Mariya V., Radchenko, Eugene V., Palyulin, Vladimir A., Burgart, Yanina V., Saloutin, Victor I., Bachurin, Sergey O., Richardson, Rudy J.
Publicado 2023

Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic...

por Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Yu, Timokhina, Elena N., Serebryakova, Olga G., Shchepochkin, Alexander V., Averkov, Maxim A., Utepova, Irina A., Demina, Nadezhda S., Radchenko, Eugene V., Palyulin, Vladimir A., Fisenko, Vladimir P., Bachurin, Sergey O., Chupakhin, Oleg N., Charushin, Valery N., Richardson, Rudy J.
Publicado 2023

Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands

por Bachurin, Sergey O., Makhaeva, Galina F., Shevtsova, Elena F., Aksinenko, Alexey Yu., Grigoriev, Vladimir V., Shevtsov, Pavel N., Goreva, Tatiana V., Epishina, Tatiana A., Kovaleva, Nadezhda V., Pushkareva, Elena A., Boltneva, Natalia P., Lushchekina, Sofya V., Gabrelyan, Alexey V., Zamoyski, Vladimir L., Dubova, Lyudmila G., Rudakova, Elena V., Fisenko, Vladimir P., Bovina, Elena V., Richardson, Rudy J.
Publicado 2021

Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease

por Bachurin, Sergey O., Shevtsova, Elena F., Makhaeva, Galina F., Aksinenko, Alexey Yu., Grigoriev, Vladimir V., Goreva, Tatiana V., Epishina, Tatiana A., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Rudakova, Elena V., Vinogradova, Darya V., Shevtsov, Pavel N., Pushkareva, Elena A., Dubova, Ludmila G., Serkova, Tatiana P., Veselov, Ivan M., Fisenko, Vladimir P., Richardson, Rudy J.
Publicado 2022

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals

por Burgart, Yanina V., Elkina, Natalia A., Shchegolkov, Evgeny V., Krasnykh, Olga P., Makhaeva, Galina F., Triandafilova, Galina A., Solodnikov, Sergey Yu., Boltneva, Natalia P., Rudakova, Elena V., Kovaleva, Nadezhda V., Serebryakova, Olga G., Ulitko, Mariya V., Borisevich, Sophia S., Gerasimova, Natalia A., Evstigneeva, Natalia P., Kozlov, Sergey A., Korolkova, Yuliya V., Minin, Artem S., Belousova, Anna V., Mozhaitsev, Evgenii S., Klabukov, Artem M., Saloutin, Victor I.
Publicado 2022