Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

por Torres, Maria J., Zhang, Xu, Slentz, Dorothy H., Koves, Timothy R., Patel, Hailee, Truskey, George A., Muoio, Deborah M.
Publicado 2022

Metabolomic analysis reveals decreased skeletal muscle amino acid content and altered fatty acid handling in obese humans

por Baker, Peter R., Boyle, Kristen E., Koves, Timothy R., Ilkayeva, Olga R., Muoio, Deborah M., Houmard, Joseph A., Friedman, Jacob E.
Publicado 2015

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

por Barrientos, Tomasa, Laothamatas, Indira, Koves, Timothy R., Soderblom, Erik J., Bryan, Miles, Moseley, M. Arthur, Muoio, Deborah M., Andrews, Nancy C.
Publicado 2015

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

por Ussher, John R., Koves, Timothy R., Jaswal, Jagdip S., Zhang, Liyan, Ilkayeva, Olga, Dyck, Jason R.B., Muoio, Deborah M., Lopaschuk, Gary D.
Publicado 2009

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome

por Williams, Ashley S., Koves, Timothy R., Pettway, Yasminye D., Draper, James A., Slentz, Dorothy H., Grimsrud, Paul A., Ilkayeva, Olga R., Muoio, Deborah M.
Publicado 2021

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

por Consitt, Leslie A., Bell, Jill A., Koves, Timothy R., Muoio, Deborah M., Hulver, Matthew W., Haynie, Kimberly R., Dohm, G. Lynis, Houmard, Joseph A.
Publicado 2010

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

por Li, Lei O., Grevengoed, Trisha J., Paul, David S., Ilkayeva, Olga, Koves, Timothy R., Pascual, Florencia, Newgard, Christopher B., Muoio, Deborah M., Coleman, Rosalind A.
Publicado 2015

Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles

por Andonian, Brian J., Chou, Ching-Heng, Ilkayeva, Olga R., Koves, Timothy R., Connelly, Margery A., Kraus, William E., Kraus, Virginia B., Huffman, Kim M.
Publicado 2019

A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling

por Dai, Qunsheng, Likes, Creighton E, Luz, Anthony L, Mao, Lan, Yeh, Jason S, Wei, Zhengzheng, Kuchibhatla, Maragatha, Ilkayeva, Olga R, Koves, Timothy R, Price, Thomas M
Publicado 2019

A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

por Kien, C. Lawrence, Bunn, Janice Y., Poynter, Matthew E., Stevens, Robert, Bain, James, Ikayeva, Olga, Fukagawa, Naomi K., Champagne, Catherine M., Crain, Karen I., Koves, Timothy R., Muoio, Deborah M.
Publicado 2013

Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations

por Chambers, Kari T., Cooper, Michael A., Swearingen, Alison R., Brookheart, Rita T., Schweitzer, George G., Weinheimer, Carla J., Kovacs, Attila, Koves, Timothy R., Muoio, Deborah M., McCommis, Kyle S., Finck, Brian N.
Publicado 2021

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

por Ussher, John R., Koves, Timothy R., Cadete, Virgilio J.J., Zhang, Liyan, Jaswal, Jagdip S., Swyrd, Suzanne J., Lopaschuk, David G., Proctor, Spencer D., Keung, Wendy, Muoio, Deborah M., Lopaschuk, Gary D.
Publicado 2010

Disruption of STIM1-mediated Ca(2+) sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass

por Wilson, Rebecca J., Lyons, Scott P., Koves, Timothy R., Bryson, Victoria G., Zhang, Hengtao, Li, TianYu, Crown, Scott B., Ding, Jin-Dong, Grimsrud, Paul A., Rosenberg, Paul B., Muoio, Deborah M.
Publicado 2021

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

por Koonen, Debby P.Y., Sung, Miranda M.Y., Kao, Cindy K.C., Dolinsky, Vernon W., Koves, Timothy R., Ilkayeva, Olga, Jacobs, René L., Vance, Dennis E., Light, Peter E., Muoio, Deborah M., Febbraio, Maria, Dyck, Jason R.B.
Publicado 2010

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

por Huffman, Kim M., Jessee, Ryan, Andonian, Brian, Davis, Brittany N., Narowski, Rachel, Huebner, Janet L., Kraus, Virginia B., McCracken, Julie, Gilmore, Brian F., Tune, K. Noelle, Campbell, Milton, Koves, Timothy R., Muoio, Deborah M., Hubal, Monica J., Kraus, William E.
Publicado 2017

Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes –...

por Bartlett, David B., Slentz, Cris A., Willis, Leslie H., Hoselton, Andrew, Huebner, Janet L., Kraus, Virginia B., Moss, Jennifer, Muehlbauer, Michael J., Spielmann, Guillaume, Muoio, Deborah M., Koves, Timothy R., Wu, Helena, Huffman, Kim M., Lord, Janet M., Kraus, William E.
Publicado 2020

Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness

por Andonian, Brian J., Koss, Alec, Koves, Timothy R., Hauser, Elizabeth R., Hubal, Monica J., Pober, David M., Lord, Janet M., MacIver, Nancie J., St Clair, E. William, Muoio, Deborah M., Kraus, William E., Bartlett, David B., Huffman, Kim M.
Publicado 2022

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

por Yamamoto, Tsunehisa, Maurya, Santosh K., Pruzinsky, Elizabeth, Batmanov, Kirill, Xiao, Yang, Sulon, Sarah M., Sakamoto, Tomoya, Wang, Yang, Lai, Ling, McDaid, Kendra S., Shewale, Swapnil V., Leone, Teresa C., Koves, Timothy R., Muoio, Deborah M., Dierickx, Pieterjan, Lazar, Mitchell A., Lewandowski, E. Douglas, Kelly, Daniel P.
Publicado 2023

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

por Guilherme, Adilson, Rowland, Leslie A., Wetoska, Nicole, Tsagkaraki, Emmanouela, Santos, Kaltinaitis B., Bedard, Alexander H., Henriques, Felipe, Kelly, Mark, Munroe, Sean, Pedersen, David J., Ilkayeva, Olga R., Koves, Timothy R., Tauer, Lauren, Pan, Meixia, Han, Xianlin, Kim, Jason K., Newgard, Christopher B., Muoio, Deborah M., Czech, Michael P.
Publicado 2023

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

por Fisher-Wellman, Kelsey H., Draper, James A., Davidson, Michael T., Williams, Ashley S., Narowski, Tara M., Slentz, Dorothy H., Ilkayeva, Olga R., Stevens, Robert D., Wagner, Gregory R., Najjar, Rami, Hirschey, Mathew D., Thompson, J. Will, Olson, David P., Kelly, Daniel P., Koves, Timothy R., Grimsrud, Paul A., Muoio, Deborah M.
Publicado 2019