Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?

por Barykin, Evgeny P., Mitkevich, Vladimir A., Kozin, Sergey A., Makarov, Alexander A.
Publicado 2017

Development of Peptide Biopharmaceuticals in Russia

por Deigin, Vladislav I., Poluektova, Elena A., Beniashvili, Allan G., Kozin, Sergey A., Poluektov, Yuri M.
Publicado 2022

Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization

por Istrate, Andrey N., Kozin, Sergey A., Zhokhov, Sergey S., Mantsyzov, Alexey B., Kechko, Olga I., Pastore, Annalisa, Makarov, Alexander A., Polshakov, Vladimir I.
Publicado 2016

Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Dise...

por Kozin, Sergey A., Barykin, Evgeny P., Telegin, Georgy B., Chernov, Alexander S., Adzhubei, Alexei A., Radko, Sergey P., Mitkevich, Vladimir A., Makarov, Alexander A.
Publicado 2018

The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation

por Radko, Sergey P., Khmeleva, Svetlana A., Kaluzhny, Dmitry N., Kechko, Olga I., Kiseleva, Yana Y., Kozin, Sergey A., Mitkevich, Vladimir A., Makarov, Alexander A.
Publicado 2020

The Effects of Endogenous Non-Peptide Molecule Isatin and Hydrogen Peroxide on Proteomic Profiling of Rat Brain Amyloid-β Binding Proteins: Relevance to Alzheimer’s Disease?

por Medvedev, Alexei E., Buneeva, Olga A., Kopylov, Arthur T., Gnedenko, Oksana V., Medvedeva, Marina V., Kozin, Sergey A., Ivanov, Alexis S., Zgoda, Victor G., Makarov, Alexander A.
Publicado 2014

Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

por Barykin, Evgeny P., Petrushanko, Irina Y., Kozin, Sergey A., Telegin, Georgy B., Chernov, Alexander S., Lopina, Olga D., Radko, Sergey P., Mitkevich, Vladimir A., Makarov, Alexander A.
Publicado 2018

Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE

por Mitkevich, Vladimir A, Barykin, Evgeny P, Eremina, Svetlana, Pani, Bibhusita, Katkova-Zhukotskaya, Olga, Polshakov, Vladimir I, Adzhubei, Alexei A, Kozin, Sergey A, Mironov, Alexander S, Makarov, Alexander A, Nudler, Evgeny
Publicado 2023

Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation

por Kechko, Olga I., Adzhubei, Alexei A., Tolstova, Anna P., Indeykina, Maria I., Popov, Igor A., Zhokhov, Sergey S., Gnuchev, Nikolay V., Mitkevich, Vladimir A., Makarov, Alexander A., Kozin, Sergey A.
Publicado 2023

N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

por Kugaevskaya, Elena V., Veselovsky, Alexander V., Indeykina, Maria I., Solovyeva, Nina I., Zharkova, Maria S., Popov, Igor A., Nikolaev, Eugene N., Mantsyzov, Alexey B., Makarov, Alexander A., Kozin, Sergey A.
Publicado 2018

Tetrapeptide Ac-HAEE-NH(2) Protects α4β2 nAChR from Inhibition by Aβ

por Barykin, Evgeny P., Garifulina, Aleksandra I., Tolstova, Anna P., Anashkina, Anastasia A., Adzhubei, Alexei A., Mezentsev, Yuri V., Shelukhina, Irina V., Kozin, Sergey A., Tsetlin, Victor I., Makarov, Alexander A.
Publicado 2020

Pharmacokinetics and Molecular Modeling Indicate nAChRα4-Derived Peptide HAEE Goes through the Blood–Brain Barrier

por Zolotarev, Yurii A., Mitkevich, Vladimir A., Shram, Stanislav I., Adzhubei, Alexei A., Tolstova, Anna P., Talibov, Oleg B., Dadayan, Alexander K., Myasoyedov, Nikolai F., Makarov, Alexander A., Kozin, Sergey A.
Publicado 2021

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

por Barykin, Evgeny P., Garifulina, Alexandra I., Kruykova, Elena V., Spirova, Ekaterina N., Anashkina, Anastasia A., Adzhubei, Alexei A., Shelukhina, Irina V., Kasheverov, Igor E., Mitkevich, Vladimir A., Kozin, Sergey A., Hollmann, Michael, Tsetlin, Victor I., Makarov, Alexander A.
Publicado 2019

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity

por Lazarev, Vladimir F, Tsolaki, Magda, Mikhaylova, Elena R, Benken, Konstantin A, Shevtsov, Maxim A, Nikotina, Alina D, Lechpammer, Mirna, Mitkevich, Vladimir A, Makarov, Alexander A, Moskalev, Alexey A, Kozin, Sergey A, Margulis, Boris A, Guzhova, Irina V, Nudler, Evgeny
Publicado 2021