Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies

por Kramnik, Igor, Beamer, Gillian
Publicado 2015

Editorial: Mycobacteria-Host Interactions: Genetics, Immunity, Pathology

por Apt, Alexander S., Kramnik, Igor, McMurray, David Neil
Publicado 2020

Medium throughput protocol for genome-based quantification of intracellular mycobacterial loads and macrophage survival during in vitro infection

por Yabaji, Shivraj M., Chatterjee, Sujoy, Waligursky, Emily, Gimelbrant, Alexander, Kramnik, Igor
Publicado 2022

An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation)

por Aryee, Martin J, Gutiérrez-Pabello, José A, Kramnik, Igor, Maiti, Tapabrata, Quackenbush, John
Publicado 2009

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

por Carow, Berit, Hauling, Thomas, Qian, Xiaoyan, Kramnik, Igor, Nilsson, Mats, Rottenberg, Martin E.
Publicado 2019

The sst1 Resistance Locus Regulates Evasion of Type I Interferon Signaling by Chlamydia pneumoniae as a Disease Tolerance Mechanism

por He, Xianbao, Berland, Robert, Mekasha, Samrawit, Christensen, Thomas G., Alroy, Joseph, Kramnik, Igor, Ingalls, Robin R.
Publicado 2013

Fine-tuning of macrophage activation using synthetic rocaglate derivatives

por Bhattacharya, Bidisha, Chatterjee, Sujoy, Devine, William G., Kobzik, Lester, Beeler, Aaron B., Porco, John A., Kramnik, Igor
Publicado 2016

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

por Kurtz, Sherry L., Rossi, Amy P., Beamer, Gillian L., Gatti, Dan M., Kramnik, Igor, Elkins, Karen L.
Publicado 2020

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by interleukin-1 receptor antagonist IL-1Ra

por Ji, Daisy X., Yamashiro, Livia H., Chen, Katherine J., Mukaida, Naofumi, Kramnik, Igor, Darwin, K. Heran, Vance, Russell E.
Publicado 2019

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

por Yabaji, Shivraj M., Rukhlenko, Oleksii S., Chatterjee, Sujoy, Bhattacharya, Bidisha, Wood, Emily, Kasaikina, Marina, Kholodenko, Boris, Gimelbrant, Alexander A., Kramnik, Igor
Publicado 2023

Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages

por Yabaji, Shivraj M., Rukhlenko, Oleksii S., Chatterjee, Sujoy, Bhattacharya, Bidisha, Wood, Emily, Kasaikina, Marina, Kholodenko, Boris N., Gimelbrant, Alexander A., Kramnik, Igor
Publicado 2023

Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model

por Rosenbloom, Raymond, Gavrish, Igor, Tseng, Anna E., Seidel, Kerstin, Yabaji, Shivraj M., Gertje, Hans P., Huber, Bertrand R., Kramnik, Igor, Crossland, Nicholas A.
Publicado 2022

Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

por Zhou, Hongwei, DeLoid, Glen, Browning, Erica, Gregory, David J., Tan, Fengxiao, Bedugnis, Alice S., Imrich, Amy, Koziel, Henry, Kramnik, Igor, Lu, Quan, Kobzik, Lester
Publicado 2012

Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

por Niazi, Muhammad K. K., Dhulekar, Nimit, Schmidt, Diane, Major, Samuel, Cooper, Rachel, Abeijon, Claudia, Gatti, Daniel M., Kramnik, Igor, Yener, Bulent, Gurcan, Metin, Beamer, Gillian
Publicado 2015

Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice

por Krug, Stefanie, Prasad, Pankaj, Xiao, Shiqi, Lun, Shichun, Ruiz-Bedoya, Camilo A., Klunk, Mariah, Ordonez, Alvaro A., Jain, Sanjay K., Srikrishna, Geetha, Kramnik, Igor, Bishai, William R.
Publicado 2023

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

por Chatterjee, Sujoy, Yabaji, Shivraj M., Rukhlenko, Oleksii S., Bhattacharya, Bidisha, Waligurski, Emily, Vallavoju, Nandini, Ray, Somak, Kholodenko, Boris N., Brown, Lauren E., Beeler, Aaron B., Ivanov, Alexander R., Kobzik, Lester, Porco, John A., Kramnik, Igor
Publicado 2021

CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice

por Koyuncu, Deniz, Niazi, Muhammad Khalid Khan, Tavolara, Thomas, Abeijon, Claudia, Ginese, Melanie L., Liao, Yanghui, Mark, Carolyn, Specht, Aubrey, Gower, Adam C., Restrepo, Blanca I., Gatti, Daniel M., Kramnik, Igor, Gurcan, Metin, Yener, Bülent, Beamer, Gillian
Publicado 2021

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

por Coppola, Mariateresa, van Meijgaarden, Krista E., Franken, Kees L. M. C., Commandeur, Susanna, Dolganov, Gregory, Kramnik, Igor, Schoolnik, Gary K., Comas, Inaki, Lund, Ole, Prins, Corine, van den Eeden, Susan J. F., Korsvold, Gro E., Oftung, Fredrik, Geluk, Annemieke, Ottenhoff, Tom H. M.
Publicado 2016

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

por Ji, Daisy X, Witt, Kristen C, Kotov, Dmitri I, Margolis, Shally R, Louie, Alexander, Chevée, Victoria, Chen, Katherine J, Gaidt, Moritz M, Dhaliwal, Harmandeep S, Lee, Angus Y, Nishimura, Stephen L, Zamboni, Dario S, Kramnik, Igor, Portnoy, Daniel A, Darwin, K Heran, Vance, Russell E
Publicado 2021

Visualizing the dynamics of tuberculosis pathology using molecular imaging

por Ordonez, Alvaro A., Tucker, Elizabeth W., Anderson, Carolyn J., Carter, Claire L., Ganatra, Shashank, Kaushal, Deepak, Kramnik, Igor, Lin, Philana L., Madigan, Cressida A., Mendez, Susana, Rao, Jianghong, Savic, Rada M., Tobin, David M., Walzl, Gerhard, Wilkinson, Robert J., Lacourciere, Karen A., Via, Laura E., Jain, Sanjay K.
Publicado 2021