SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e

por Kulcsár, Péter István, Tálas, András, Ligeti, Zoltán, Krausz, Sarah Laura, Welker, Ervin
Publicado 2022

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

por Sangeetham, Sudheer Babu, Engelke, Anna Dorothee, Fodor, Elfrieda, Krausz, Sarah Laura, Tatzelt, Jörg, Welker, Ervin
Publicado 2021

BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors

por Tálas, András, Simon, Dorottya A., Kulcsár, Péter I., Varga, Éva, Krausz, Sarah L., Welker, Ervin
Publicado 2021

PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells

por Simon, Dorottya Anna, Tálas, András, Kulcsár, Péter István, Biczók, Zsuzsanna, Krausz, Sarah Laura, Várady, György, Welker, Ervin
Publicado 2022

Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs

por Huszár, Krisztina, Welker, Zsombor, Györgypál, Zoltán, Tóth, Eszter, Ligeti, Zoltán, Kulcsár, Péter István, Dancsó, János, Tálas, András, Krausz, Sarah Laura, Varga, Éva, Welker, Ervin
Publicado 2023

A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets

por Kulcsár, Péter István, Tálas, András, Ligeti, Zoltán, Tóth, Eszter, Rakvács, Zsófia, Bartos, Zsuzsa, Krausz, Sarah Laura, Welker, Ágnes, Végi, Vanessza Laura, Huszár, Krisztina, Welker, Ervin
Publicado 2023

Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases

por Tóth, Eszter, Varga, Éva, Kulcsár, Péter István, Kocsis-Jutka, Virág, Krausz, Sarah Laura, Nyeste, Antal, Welker, Zsombor, Huszár, Krisztina, Ligeti, Zoltán, Tálas, András, Welker, Ervin
Publicado 2020

Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype

por García, Samuel, Krausz, Sarah, Ambarus, Carmen A., Fernández, Beatriz Malvar, Hartkamp, Linda M., van Es, Inge E., Hamann, Jörg, Baeten, Dominique L., Tak, Paul P., Reedquist, Kris A.
Publicado 2014

Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants

por Tóth, Eszter, Czene, Bernadett C, Kulcsár, Péter I, Krausz, Sarah L, Tálas, András, Nyeste, Antal, Varga, Éva, Huszár, Krisztina, Weinhardt, Nóra, Ligeti, Zoltán, Borsy, Adrienn É, Fodor, Elfrieda, Welker, Ervin
Publicado 2018

Molecular tumour boards and molecular diagnostics for patients with cancer in the Netherlands: experiences, challenges, and aspirations

por Willemsen, Annelieke E. C. A. B., Krausz, Sarah, Ligtenberg, Marjolijn J. L., Grünberg, Katrien, Groen, Harry J. M., Voest, Emile E., Cuppen, Edwin P. J. G., van Laarhoven, Hanneke W. M., van Herpen, Carla M. L.
Publicado 2019

A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis

por Abreu, Joana RF, Dontje, Wendy, Krausz, Sarah, de Launay, Daphne, van Hennik, Paula B, van Stalborch, Anne-Marieke, ten Klooster, Jean-Paul, Sanders, Marjolein E, Reedquist, Kris A, Vervoordeldonk, Margriet J, Hordijk, Peter L, Tak, Paul P
Publicado 2010

A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a ‘self-cleaving’ GFP-expression plasmid

por Tálas, András, Kulcsár, Péter István, Weinhardt, Nóra, Borsy, Adrienn, Tóth, Eszter, Szebényi, Kornélia, Krausz, Sarah Laura, Huszár, Krisztina, Vida, István, Sturm, Ádám, Gordos, Bianka, Hoffmann, Orsolya Ivett, Bencsura, Petra, Nyeste, Antal, Ligeti, Zoltán, Fodor, Elfrieda, Welker, Ervin
Publicado 2017

Circulating tumor DNA predicts outcome in metastatic gastroesophageal cancer

por van Velzen, Merel J. M., Creemers, Aafke, van den Ende, Tom, Schokker, Sandor, Krausz, Sarah, Reinten, Roy J., Dijk, Frederike, van Noesel, Carel J. M., Halfwerk, Hans, Meijer, Sybren L., Mearadji, Banafsche, Derks, Sarah, Bijlsma, Maarten F., van Laarhoven, Hanneke W. M.
Publicado 2022