Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

por Bogacz, Marta, Krauth-Siegel, R Luise
Publicado 2018

Natural Sesquiterpene Lactones of the 4,15-iso-Atriplicolide Type are Inhibitors of Trypanothione Reductase

por Lenz, Mairin, Krauth-Siegel, R. Luise, Schmidt, Thomas J.
Publicado 2019

The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes

por Bogacz, Marta, Dirdjaja, Natalie, Wimmer, Benedikt, Habich, Carina, Krauth-Siegel, R. Luise
Publicado 2020

Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling

por Leroux, Alejandro E., Haanstra, Jurgen R., Bakker, Barbara M., Krauth-Siegel, R. Luise
Publicado 2013

Cytosolic Peroxidases Protect the Lysosome of Bloodstream African Trypanosomes from Iron-Mediated Membrane Damage

por Hiller, Corinna, Nissen, Amrei, Benítez, Diego, Comini, Marcelo A., Krauth-Siegel, R. Luise
Publicado 2014

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

por Ebersoll, Samantha, Bogacz, Marta, Günter, Lina M, Dick, Tobias P, Krauth-Siegel, R Luise
Publicado 2020

Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach

por Beig, Mathias, Oellien, Frank, Garoff, Linnéa, Noack, Sandra, Krauth-Siegel, R. Luise, Selzer, Paul M.
Publicado 2015

Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes—A Quantitative Redox Proteome and Thiol Analysis

por Ulrich, Kathrin, Finkenzeller, Caroline, Merker, Sabine, Rojas, Federico, Matthews, Keith, Ruppert, Thomas, Krauth-Siegel, R. Luise
Publicado 2017

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

por Ebersoll, Samantha, Musunda, Blessing, Schmenger, Torsten, Dirdjaja, Natalie, Bonilla, Mariana, Manta, Bruno, Ulrich, Kathrin, Comini, Marcelo A., Krauth-Siegel, R. Luise
Publicado 2018

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

por Currier, Rachel B., Ulrich, Kathrin, Leroux, Alejandro E., Dirdjaja, Natalie, Deambrosi, Matías, Bonilla, Mariana, Ahmed, Yasar Luqman, Adrian, Lorenz, Antelmann, Haike, Jakob, Ursula, Comini, Marcelo A., Krauth-Siegel, R. Luise
Publicado 2019

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors

por González-González, Alonzo, Sánchez-Sánchez, Oscar, Krauth-Siegel, R. Luise, Bolognesi, Maria Laura, Gớmez-Escobedo, Rogelio, Nogueda-Torres, Benjamín, Vázquez-Jiménez, Lenci K., Saavedra, Emma, Encalada, Rusely, Espinoza-Hicks, José Carlos, Paz-González, Alma D., Rivera, Gildardo
Publicado 2022

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

por Chacón-Vargas, Karla Fabiola, Nogueda-Torres, Benjamin, Sánchez-Torres, Luvia E., Suarez-Contreras, Erick, Villalobos-Rocha, Juan Carlos, Torres-Martinez, Yuridia, Lara-Ramirez, Edgar E., Fiorani, Giulia, Krauth-Siegel, R. Luise, Bolognesi, Maria Laura, Monge, Antonio, Rivera, Gildardo
Publicado 2017