Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

por Calvier, E. A. M., Krekels, E. H. J., Johnson, T. N., Rostami-Hodjegan, A., Tibboel, D., Knibbe, Catherijne A. J.
Publicado 2019

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine

por Krekels, E H J, Neely, M, Panoilia, E, Tibboel, D, Capparelli, E, Danhof, M, Mirochnick, M, Knibbe, C A J
Publicado 2012

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties

por Krekels, E H J, Johnson, T N, den Hoedt, S M, Rostami-Hodjegan, A, Danhof, M, Tibboel, D, Knibbe, C A J
Publicado 2012

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass

por Mian, P., Valkenburg, A.J., Allegaert, K., Koch, B.C.P., Breatnach, C.V., Knibbe, C.A.J., Tibboel, D., Krekels, E.H.J.
Publicado 2019