Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

por Krenning, Lenno, Sonneveld, Stijn, Tanenbaum, Marvin E
Publicado 2022

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

por Espeut, Julien, Cheerambathur, Dhanya K., Krenning, Lenno, Oegema, Karen, Desai, Arshad
Publicado 2012

Chromosomes trapped in micronuclei are liable to segregation errors

por Soto, Mar, García-Santisteban, Iraia, Krenning, Lenno, Medema, René H., Raaijmakers, Jonne A.
Publicado 2018

Combined Inactivation of Pocket Proteins and APC/C(Cdh1) by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

por Shaltiel, Indra A., Llopis, Alba, Aprelia, Melinda, Klompmaker, Rob, Menegakis, Apostolos, Krenning, Lenno, Medema, René H.
Publicado 2021

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

por Feringa, Femke M., Krenning, Lenno, Koch, André, van den Berg, Jeroen, van den Broek, Bram, Jalink, Kees, Medema, René H.
Publicado 2016

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells

por García-Santisteban, Iraia, Llopis, Alba, Krenning, Lenno, Vallejo-Rodríguez, Jon, van den Broek, Bram, Zubiaga, Ana M., Medema, René H.
Publicado 2021

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

por Menegakis, Apostolos, Klompmaker, Rob, Vennin, Claire, Arbusà, Aina, Damen, Maartje, van den Broek, Bram, Zips, Daniel, van Rheenen, Jacco, Krenning, Lenno, Medema, René H.
Publicado 2021

MND1 enables homologous recombination in somatic cells primarily outside the context of replication

por Koob, Lisa, Friskes, Anoek, van Bergen, Louise, Feringa, Femke M., van den Broek, Bram, Koeleman, Emma S., van Beek, Ellis, Schubert, Michael, Blomen, Vincent A., Brummelkamp, Thijn R., Krenning, Lenno, Medema, René H.
Publicado 2023

Double-strand break toxicity is chromatin context independent

por Friskes, Anoek, Koob, Lisa, Krenning, Lenno, Severson, Tesa M, Koeleman, Emma S, Vergara, Xabier, Schubert, Michael, van den Berg, Jeroen, Evers, Bastiaan, Manjón, Anna G, Joosten, Stacey, Kim, Yongsoo, Zwart, Wilbert, Medema, René H
Publicado 2022

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

por Jost, Marco, Chen, Yuwen, Gilbert, Luke A., Horlbeck, Max A., Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y., Stern, Jacob J., Prota, Andrea E., Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E., Weissman, Jonathan S.
Publicado 2017

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent

por Jost, Marco, Chen, Yuwen, Gilbert, Luke A., Horlbeck, Max A., Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y., Stern, Jacob J., Prota, Andrea E., Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E., Weissman, Jonathan S.
Publicado 2020

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

por Pogacar, Ziva, Johnson, Jackie L., Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H., Beijersbergen, Roderick L., Bernards, Rene, Leite de Oliveira, Rodrigo
Publicado 2022