Phase separation in biology; functional organization of a higher order

por Mitrea, Diana M., Kriwacki, Richard W.
Publicado 2016

Exploring Relationships between the Density of Charged Tracts within Disordered Regions and Phase Separation

por Somjee, Ramiz, Mitrea, Diana M., Kriwacki, Richard W.
Publicado 2020

Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms

por Ferrolino, Mylene C., Mitrea, Diana M., Michael, J. Robert, Kriwacki, Richard W.
Publicado 2018

Phase separation underlies interactions of the SARS-CoV-2 nucleocapsid protein with nucleoli

por Dogra, Priyanka, Shirnekhi, Hazheen, Ferrolino, Mylene C., Tolbert, Michele, Park, Cheon-Gil, Kriwacki, Richard W.
Publicado 2023

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins

por Beveridge, Rebecca, Migas, Lukasz G., Das, Rahul K., Pappu, Rohit V., Kriwacki, Richard W., Barran, Perdita E.
Publicado 2019

BID-induced structural changes in BAK promote apoptosis

por Moldoveanu, Tudor, Grace, Christy R., Llambi, Fabien, Nourse, Amanda, Fitzgerald, Patrick, Gehring, Kalle, Kriwacki, Richard W., Green, Douglas R.
Publicado 2013

Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1)

por Iconaru, Luigi I., Ban, David, Bharatham, Kavitha, Ramanathan, Arvind, Zhang, Weixing, Shelat, Anang A., Zuo, Jian, Kriwacki, Richard W.
Publicado 2015

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

por Calabrese, Matthew F., Scott, Daniel C., Duda, David M., Grace, Christy R.R., Kurinov, Igor, Kriwacki, Richard W., Schulman, Brenda A.
Publicado 2011

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

por Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W., Waddell, M. Brett, Guy, R. Kiplin, Luthman, Kristina, Grøtli, Morten
Publicado 2015

Chromatin localization of nucleophosmin organizes ribosome biogenesis

por Ugolini, Ilaria, Bilokapic, Silvija, Ferrolino, Mylene, Teague, Josiah, Yan, Yinxia, Zhou, Xuelin, Deshmukh, Ashish, White, Michael, Kriwacki, Richard W., Halic, Mario
Publicado 2022

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

por Wang, Yuefeng, Fisher, John C., Mathew, Rose, Ou, Li, Otieno, Steve, Sublett, Jack, Xiao, Limin, Chen, Jianhan, Roussel, Martine F., Kriwacki, Richard W.
Publicado 2011

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

por Pettersson, Mariell, Bliman, David, Jacobsson, Jimmy, Nilsson, Jesper R., Min, Jaeki, Iconaru, Luigi, Guy, R. Kiplin, Kriwacki, Richard W., Andréasson, Joakim, Grøtli, Morten
Publicado 2015

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

por Mitrea, Diana M, Cika, Jaclyn A, Guy, Clifford S, Ban, David, Banerjee, Priya R, Stanley, Christopher B, Nourse, Amanda, Deniz, Ashok A, Kriwacki, Richard W
Publicado 2016

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

por Follis, Ariele Viacava, Llambi, Fabien, Kalkavan, Halime, Yao, Yong, Phillips, Aaron H., Park, Cheon-Gil, Marassi, Francesca M., Green, Douglas R., Kriwacki, Richard W.
Publicado 2018

Biomolecular condensates form spatially inhomogeneous network fluids

por Dar, Furqan, Cohen, Samuel R., Mitrea, Diana M., Phillips, Aaron H., Nagy, Gergely, Leite, Wellington C., Stanley, Christopher B., Choi, Jeong-Mo, Kriwacki, Richard W., Pappu, Rohit V.
Publicado 2023

Inherited germline TP53 mutation encodes a protein with an aberrant C-terminal motif in a case of pediatric adrenocortical tumor

por Pinto, Emilia M., Ribeiro, Raul C., Kletter, Gad B., Lawrence, John P., Jenkins, Jesse J., Wang, Jinling, Shurtleff, Sheila, McGregor, Lisa, Kriwacki, Richard W., Zambetti, Gerard P.
Publicado 2010

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

por Mitrea, Diana M., Cika, Jaclyn A., Stanley, Christopher B., Nourse, Amanda, Onuchic, Paulo L., Banerjee, Priya R., Phillips, Aaron H., Park, Cheon-Gil, Deniz, Ashok A., Kriwacki, Richard W.
Publicado 2018

EM Structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown

por Frye, Jeremiah J., Brown, Nicholas G., Petzold, Georg, Watson, Edmond R., Grace, Christy R. R., Nourse, Amanda, Jarvis, Marc A., Kriwacki, Richard W., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Publicado 2013

PUMA Binding Induces Partial Unfolding within BCL-xL to Disrupt p53 Binding and Promote Apoptosis

por Follis, Ariele Viacava, Chipuk, Jerry E., Fisher, John C., Yun, Mi-Kyung, Grace, Christy R., Nourse, Amanda, Baran, Katherine, Ou, Li, Min, Lie, White, Stephen W., Green, Douglas R., Kriwacki, Richard W.
Publicado 2013

From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion

por Quinn, Emily A., Maciaszek, Jamie L., Pinto, Emilia M., Phillips, Aaron H., Berdy, David, Khandwala, Mohammad, Upadhyaya, Santhosh A., Zambetti, Gerard P., Kriwacki, Richard W., Ellison, David W., Nichols, Kim E., Kesserwan, Chimene
Publicado 2019