Antitumor activity of LSD1 inhibitors in lung cancer

por Mohammad, Helai P., Kruger, Ryan G.
Publicado 2016

Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

por O’Brien, Shane, Butticello, Michael, Thompson, Christine, Wilson, Boris, Wyce, Anastasia, Mahajan, Vivek, Kruger, Ryan, Mohammad, Helai, Fedoriw, Andy
Publicado 2023

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

por Van Aller, Glenn S., Reynoird, Nicolas, Barbash, Olena, Huddleston, Michael, Liu, Shichong, Zmoos, Anne-Flore, McDevitt, Patrick, Sinnamon, Robert, Le, BaoChau, Mas, Gloria, Annan, Roland, Sage, Julien, Garcia, Benjamin A., Tummino, Peter J., Gozani, Or, Kruger, Ryan G.
Publicado 2012

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

por Mazur, Pawel K., Reynoird, Nicolas, Khatri, Purvesh, Jansen, Pascal W.T.C., Wilkinson, Alex, Liu, Shichong, Barbash, Olena, Van Aller, Glenn S., Huddleston, Michael, Dhanak, Dashyant, Tummino, Peter J., Kruger, Ryan G., Garcia, Benjamin, Butte, Atul J., Vermeulen, Michiel, Sage, Julien, Gozani, Or
Publicado 2014

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

por Gerhart, Sarah V., Kellner, Wendy A., Thompson, Christine, Pappalardi, Melissa B., Zhang, Xi-Ping, Montes de Oca, Rocio, Penebre, Elayne, Duncan, Kenneth, Boriack-Sjodin, Ann, Le, BaoChau, Majer, Christina, McCabe, Michael T., Carpenter, Chris, Johnson, Neil, Kruger, Ryan G., Barbash, Olena
Publicado 2018

Histone Demethylase LSD1 is required for Germinal Center formation and BCL6-driven lymphomagenesis

por Hatzi, Katerina, Geng, Huimin, Doane, Ashley S., Meydan, Cem, LaRiviere, Reed, Cardenas, Mariano, Duy, Cihangir, Shen, Hao, Vidal, Maria Nieves Calvo, Baslan, Timour, Mohammad, Helai P., Kruger, Ryan G., Shaknovich, Rita, Haberman, Ann M., Inghirami, Giorgio, Lowe, Scott W., Melnick, Ari M.
Publicado 2018

MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers

por Wyce, Anastasia, Matteo, Jeanne J., Foley, Shawn W., Felitsky, Daniel J., Rajapurkar, Satyajit R., Zhang, Xi-Ping, Musso, Melissa C., Korenchuk, Susan, Karpinich, Natalie O., Keenan, Kathryn M., Stern, Melissa, Mathew, Lijoy K., McHugh, Charles F., McCabe, Michael T., Tummino, Peter J., Kruger, Ryan G., Carpenter, Christopher, Barbash, Olena
Publicado 2018

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subt...

por Smitheman, Kimberly N., Severson, Tesa M., Rajapurkar, Satyajit R., McCabe, Michael T., Karpinich, Natalie, Foley, James, Pappalardi, Melissa B., Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E., Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K., Carpenter, Christopher L., Kruger, Ryan G., Wessels, Lodewyk, Mohammad, Helai P.
Publicado 2019

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

por Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.
Publicado 2020

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

por Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heidi M., Kruger, Ryan G., McCabe, Michael T., Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J., Mitchell, Lorna H., Duncan, Kenneth W., Moyer, Mikel P., Copeland, Robert A., Smith, Jesse, Chesworth, Richard, Ribich, Scott A.
Publicado 2017

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

por Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.
Publicado 2019