Dietary Methionine Restriction Reverses Liver Cancer Driving Metabotype in GNMT KO Mice

por Hall, Madeline, Krupenko, Natalia
Publicado 2022

Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner

por Barron, Keri, Ogretmen, Besim, Krupenko, Natalia
Publicado 2021

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution

por Holmes, Roger S., Barron, Keri A., Krupenko, Natalia I.
Publicado 2018

ALDH1L1 Inhibits Cell Motility Via Dephosphorylation of Cofilin by PP1 and PP2A

por Oleinik, Natalia V., Krupenko, Natalia I., Krupenko, Sergey A.
Publicado 2010

Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner

por Fekry, Baharan, Esmaeilniakooshkghazi, Amin, Krupenko, Sergey A., Krupenko, Natalia I.
Publicado 2016

Structure of putative tumor suppressor ALDH1L1

por Tsybovsky, Yaroslav, Sereda, Valentin, Golczak, Marcin, Krupenko, Natalia I., Krupenko, Sergey A.
Publicado 2022

A Novel Tumor Suppressor Function of Glycine N-Methyltransferase Is Independent of Its Catalytic Activity but Requires Nuclear Localization

por DebRoy, Suchandra, Kramarenko, Inga I., Ghose, Sampa, Oleinik, Natalia V., Krupenko, Sergey A., Krupenko, Natalia I.
Publicado 2013

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G(0)/G(1) to S-phase

por Khan, Qasim A., Pediaditakis, Peter, Malakhau, Yuryi, Esmaeilniakooshkghazi, Amin, Ashkavand, Zahra, Sereda, Valentin, Krupenko, Natalia I., Krupenko, Sergey A.
Publicado 2018

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver

por Krupenko, Natalia I., Sharma, Jaspreet, Pediaditakis, Peter, Fekry, Baharan, Helke, Kristi L., Du, Xiuxia, Sumner, Susan, Krupenko, Sergey A.
Publicado 2019

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

por Krupenko, Natalia I., Sharma, Jaspreet, Pediaditakis, Peter, Helke, Kristi L., Hall, Madeline S., Du, Xiuxia, Sumner, Susan, Krupenko, Sergey A.
Publicado 2020

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

por Krupenko, Natalia I., Sharma, Jaspreet, Fogle, Halle M., Pediaditakis, Peter, Strickland, Kyle C., Du, Xiuxia, Helke, Kristi L., Sumner, Susan, Krupenko, Sergey A.
Publicado 2021

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

por Sharma, Jaspreet, Rushing, Blake R., Hall, Madeline S., Helke, Kristi L., McRitchie, Susan L., Krupenko, Natalia I., Sumner, Susan J., Krupenko, Sergey A.
Publicado 2022

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

por Rushing, Blake R., Fogle, Halle M., Sharma, Jaspreet, You, Mikyoung, McCormac, Jonathan P., Molina, Sabrina, Sumner, Susan, Krupenko, Natalia I., Krupenko, Sergey A.
Publicado 2022

C(16)-ceramide is a natural regulatory ligand of p53 in cellular stress response

por Fekry, Baharan, Jeffries, Kristen A., Esmaeilniakooshkghazi, Amin, Szulc, Zdzislaw M., Knagge, Kevin J., Kirchner, David R., Horita, David A., Krupenko, Sergey A., Krupenko, Natalia I.
Publicado 2018

Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome

por Sarret, Catherine, Ashkavand, Zahra, Paules, Evan, Dorboz, Imen, Pediaditakis, Peter, Sumner, Susan, Eymard-Pierre, Eléonore, Francannet, Christine, Krupenko, Natalia I., Boespflug-Tanguy, Odile, Krupenko, Sergey A.
Publicado 2019

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

por Pelligra, Angela, Mrugala, Jessica, Griess, Kerstin, Kirschner, Philip, Nortmann, Oliver, Bartosinska, Barbara, Köster, Andrea, Krupenko, Natalia I., Gebel, Dominik, Westhoff, Philipp, Steckel, Bodo, Eberhard, Daniel, Herebian, Diran, Belgardt, Bengt-Frederik, Schrader, Jürgen, Weber, Andreas P.M., Krupenko, Sergey A., Lammert, Eckhard
Publicado 2023

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

por Pelligra, Angela, Mrugala, Jessica, Griess, Kerstin, Kirschner, Philip, Nortmann, Oliver, Bartosinska, Barbara, Köster, Andrea, Krupenko, Natalia I., Gebel, Dominik, Westhoff, Philipp, Steckel, Bodo, Eberhard, Daniel, Herebian, Diran, Belgardt, Bengt-Frederik, Schrader, Jürgen, Weber, Andreas P.M., Krupenko, Sergey A., Lammert, Eckhard
Publicado 2023