Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

por Kryštof, Vladimír, Baumli, Sonja, Fürst, Robert
Publicado 2012

Anticancer effect of zanubrutinib in HER2-positive breast cancer cell lines

por Dostálová, Hana, Jorda, Radek, Řezníčková, Eva, Kryštof, Vladimír
Publicado 2023

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

por Lasák, Pavel, Motyka, Kamil, Kryštof, Vladimír, Stýskala, Jakub
Publicado 2018

Adamantane-Substituted Purine Nucleosides: Synthesis, Host–Guest Complexes with β-Cyclodextrin and Biological Activity

por Rudolfová, Jana, Kryštof, Vladimír, Nečas, Marek, Vícha, Robert, Rouchal, Michal
Publicado 2022

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity

por Rouchal, Michal, Rudolfová, Jana, Kryštof, Vladimír, Vojáčková, Veronika, Čmelík, Richard, Vícha, Robert
Publicado 2021

Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis

por Wang, Keqing, Hampson, Peter, Hazeldine, Jon, Krystof, Vladimir, Strnad, Miroslav, Pechan, Paul, M., Janet
Publicado 2012

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

por Mrozek-Wilczkiewicz, Anna, Spaczynska, Ewelina, Malarz, Katarzyna, Cieslik, Wioleta, Rams-Baron, Marzena, Kryštof, Vladimír, Musiol, Robert
Publicado 2015

Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines

por Razmienė, Beatričė, Řezníčková, Eva, Dambrauskienė, Vaida, Ostruszka, Radek, Kubala, Martin, Žukauskaitė, Asta, Kryštof, Vladimír, Šačkus, Algirdas, Arbačiauskienė, Eglė
Publicado 2021

Trisubstituted Pyrazolopyrimidines as Novel Angiogenesis Inhibitors

por Weitensteiner, Sabine B., Liebl, Johanna, Krystof, Vladimir, Havlíček, Libor, Gucký, Tomáš, Strnad, Miroslav, Fürst, Robert, Vollmar, Angelika M., Zahler, Stefan
Publicado 2013

Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy

por Holcakova, Jitka, Muller, Petr, Tomasec, Peter, Hrstka, Roman, Nekulova, Marta, Krystof, Vladimir, Strnad, Miroslav, Wilkinson, Gavin W. G., Vojtesek, Borivoj
Publicado 2014

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

por Tomanová, Monika, Kozlanská, Karolína, Jorda, Radek, Jedinák, Lukáš, Havlíková, Tereza, Řezníčková, Eva, Peřina, Miroslav, Klener, Pavel, Dolníková, Alexandra, Cankař, Petr, Kryštof, Vladimír
Publicado 2022

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

por Štětková, Monika, Growková, Kateřina, Fojtík, Petr, Valčíková, Barbora, Palušová, Veronika, Verlande, Amandine, Jorda, Radek, Kryštof, Vladimír, Hejret, Václav, Alexiou, Panagiotis, Rotrekl, Vladimír, Uldrijan, Stjepan
Publicado 2020

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment...

por Bertrand, Jeanluc, Dostálová, Hana, Kryštof, Vladimír, Jorda, Radek, Delgado, Thalía, Castro-Alvarez, Alejandro, Mella, Jaime, Cabezas, David, Faúndez, Mario, Espinosa-Bustos, Christian, Salas, Cristian O.
Publicado 2022

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

por O. Salas, Cristian, Zarate, Ana Maria, Kryštof, Vladimir, Mella, Jaime, Faundez, Mario, Brea, Jose, Loza, María Isabel, Brito, Ivan, Hendrychová, Denisa, Jorda, Radek, Cabrera, Alan R., Tapia, Ricardo A., Espinosa-Bustos, Christian
Publicado 2019

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping

por Břehová, Petra, Řezníčková, Eva, Škach, Kryštof, Jorda, Radek, Dejmek, Milan, Vojáčková, Veronika, Šála, Michal, Kovalová, Markéta, Dračínský, Martin, Dolníková, Alexandra, Strmeň, Timotej, Kinnertová, Monika, Chalupský, Karel, Dvořáková, Alexandra, Gucký, Tomáš, Mertlíková Kaiserová, Helena, Klener, Pavel, Nencka, Radim, Kryštof, Vladimír
Publicado 2023