Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overp...

por Krzyscik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek
Publicado 2020

Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducin...

por Nawrocka, Daria, Krzyscik, Mateusz Adam, Sluzalska, Katarzyna Dominika, Otlewski, Jacek
Publicado 2023

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

por Nawrocka, Daria, Krzyscik, Mateusz Adam, Opaliński, Łukasz, Zakrzewska, Malgorzata, Otlewski, Jacek
Publicado 2020

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent

por Jendryczko, Karolina, Rzeszotko, Jakub, Krzyscik, Mateusz Adam, Szymczyk, Jakub, Otlewski, Jacek, Szlachcic, Anna
Publicado 2021

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers

por Porębska, Natalia, Knapik, Agata, Poźniak, Marta, Krzyścik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Publicado 2021

Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies

por Jendryczko, Karolina, Rzeszotko, Jakub, Krzyscik, Mateusz Adam, Kocyła, Anna, Szymczyk, Jakub, Otlewski, Jacek, Szlachcic, Anna
Publicado 2022

The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases

por Poźniak, Marta, Żukowska, Dominika, Gędaj, Aleksandra, Krzyścik, Mateusz Adam, Porębska, Natalia, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Publicado 2022

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors

por Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Sokolowska-Wedzina, Aleksandra, Lobocki, Michal, Swiderska, Karolina Weronika, Krowarsch, Daniel, Wiedlocha, Antoni, Otlewski, Jacek
Publicado 2017

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

por Pozniak, Marta, Sokolowska‐Wedzina, Aleksandra, Jastrzebski, Kamil, Szymczyk, Jakub, Porebska, Natalia, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Miaczynska, Marta, Otlewski, Jacek, Opalinski, Lukasz
Publicado 2020

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

por Poźniak, Marta, Porębska, Natalia, Krzyścik, Mateusz Adam, Sokołowska-Wędzina, Aleksandra, Jastrzębski, Kamil, Sochacka, Martyna, Szymczyk, Jakub, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Publicado 2021

Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors

por Poźniak, Marta, Porębska, Natalia, Jastrzębski, Kamil, Krzyścik, Mateusz Adam, Kucińska, Marika, Zarzycka, Weronika, Barbach, Agnieszka, Zakrzewska, Małgorzata, Otlewski, Jacek, Miączyńska, Marta, Opaliński, Łukasz
Publicado 2021