Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

por Chhunchha, Bhavana, Kubo, Eri, Singh, Dhirendra P.
Publicado 2019

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

por Chhunchha, Bhavana, Kubo, Eri, Singh, Dhirendra P.
Publicado 2020

Switching of Redox Signaling by Prdx6 Expression Decides Cellular Fate by Hormetic Phenomena Involving Nrf2 and Reactive Oxygen Species

por Chhunchha, Bhavana, Kubo, Eri, Singh, Dhirendra P.
Publicado 2022

Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

por Chhunchha, Bhavana, Kubo, Eri, Singh, Dhirendra P.
Publicado 2022

Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens

por Kubo, Eri, Hasanova, Nailia, Sasaki, Hiroshi, Singh, Dhirendra P
Publicado 2013

Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation

por Chhunchha, Bhavana, Kubo, Eri, Fatma, Nigar, Singh, Dhirendra P
Publicado 2017

Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress

por Chhunchha, Bhavana, Kubo, Eri, Singh, Prerna, Singh, Dhirendra P.
Publicado 2018

Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity

por Kubo, Eri, Shibata, Teppei, Singh, Dhirendra P., Sasaki, Hiroshi
Publicado 2018

Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

por Chhunchha, Bhavana, Singh, Prerna, Singh, Dhirendra P., Kubo, Eri
Publicado 2018

Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

por Chhunchha, Bhavana, Kubo, Eri, Kompella, Uday B., Singh, Dhirendra P.
Publicado 2021

Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response

por Chhunchha, Bhavana, Kubo, Eri, Krueger, Ronald R., Singh, Dhirendra P.
Publicado 2023

Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells

por Chhunchha, Bhavana, Kumar, Rakesh, Kubo, Eri, Thakur, Priyanka, Singh, Dhirendra P.
Publicado 2023

Elevated tropomyosin expression is associated with epithelial–mesenchymal transition of lens epithelial cells

por Kubo, Eri, Hasanova, Nailia, Fatma, Nigar, Sasaki, Hiroshi, Singh, Dhirendra P
Publicado 2013

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

por Kubo, Eri, Chhunchha, Bhavana, Singh, Prerna, Sasaki, Hiroshi, Singh, Dhirendra P.
Publicado 2017

Role of Decorin in the Lens and Ocular Diseases

por Kubo, Eri, Shibata, Shinsuke, Shibata, Teppei, Sasaki, Hiroshi, Singh, Dhirendra P.
Publicado 2022

Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells

por Xu, Xiaohe, Yoshizaki, Hisayoshi, Ishigaki, Yasuhito, Kubo, Eri, Minato, Hiroshi, Kiyokawa, Etsuko
Publicado 2017

Enhancement of Amyloid β(1–43) Production in the Lens Epithelium of Japanese Type 2 Diabetic Patients

por Mano, Yu, Otake, Hiroko, Shibata, Teppei, Kubo, Eri, Sasaki, Hiroshi, Nagai, Noriaki
Publicado 2020

Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells

por Ishida, Hidetoshi, Shibata, Teppei, Shibata, Shinsuke, Tanaka, Yuki, Sasaki, Hiroshi, Kubo, Eri
Publicado 2020

Degradation of connexin 50 protein causes waterclefts in human lens

por Nakazawa, Yosuke, Shibata, Teppei, Nagai, Noriaki, Kubo, Eri, Tamura, Hiroomi, Sasaki, Hiroshi
Publicado 2020

Acute cataract by a high-intensity focused ultrasound procedure: a case report

por Ikoma, Toru, Shibata, Teppei, Shibata, Naoko, Mito, Tsuyoshi, Kubo, Eri, Sasaki, Hiroshi
Publicado 2022