Editorial: Genetics of Complex Traits and Diseases From Under-Represented Populations

por Fatumo, Segun, Chikowore, Tinashe, Kuchenbaecker, Karoline
Publicado 2022

Genetic risk scores and dementia risk across different ethnic groups in UK Biobank

por Mukadam, Naaheed, Giannakopoulou, Olga, Bass, Nick, Kuchenbaecker, Karoline, McQuillin, Andrew
Publicado 2022

Mendelian randomization analyses implicate biogenesis of translation machinery in human aging

por Javidnia, Sara, Cranwell, Stephen, Mueller, Stefanie H., Selman, Colin, Tullet, Jennifer M.A., Kuchenbaecker, Karoline, Alic, Nazif
Publicado 2022

Complex disease genetics: present and future translational applications

por Holmes, Michael V, Shah, Sonia H, Angelakopoulou, Aspasia, Khan, Tauseef, Swerdlow, Daniel, Kuchenbaecker, Karoline, Sofat, Reecha, Shah, Tina
Publicado 2009

Investigating the association between schizophrenia and distance visual acuity: Mendelian randomisation study

por Shoham, Natalie, Dunca, Diana, Cooper, Claudia, Hayes, Joseph F., McQuillin, Andrew, Bass, Nick, Lewis, Gemma, Kuchenbaecker, Karoline
Publicado 2023

Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK

por Farmaki, Aliki-Eleni, Garfield, Victoria, Eastwood, Sophie V., Farmer, Ruth E., Mathur, Rohini, Giannakopoulou, Olga, Patalay, Praveetha, Kuchenbaecker, Karoline, Sattar, Naveed, Hughes, Alun, Bhaskaran, Krishnan, Smeeth, Liam, Chaturvedi, Nish
Publicado 2021

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

por Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
Publicado 2016

Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

por Prins, Bram P., Kuchenbaecker, Karoline B., Bao, Yanchun, Smart, Melissa, Zabaneh, Delilah, Fatemifar, Ghazaleh, Luan, Jian’an, Wareham, Nick J., Scott, Robert A., Perry, John R. B., Langenberg, Claudia, Benzeval, Michaela, Kumari, Meena, Zeggini, Eleftheria
Publicado 2017

The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics

por Austin-Zimmerman, Isabelle, Wronska, Marta, Wang, Baihan, Irizar, Haritz, Thygesen, Johan H., Bhat, Anjali, Denaxas, Spiros, Fatemifar, Ghazaleh, Finan, Chris, Harju-Seppänen, Jasmine, Giannakopoulou, Olga, Kuchenbaecker, Karoline, Zartaloudi, Eirini, McQuillin, Andrew, Bramon, Elvira
Publicado 2021

Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study

por Hodgson, Sam, Huang, Qin Qin, Sallah, Neneh, Griffiths, Chris J., Newman, William G., Trembath, Richard C., Wright, John, Lumbers, R. Thomas, Kuchenbaecker, Karoline, van Heel, David A., Mathur, Rohini, Martin, Hilary C., Finer, Sarah
Publicado 2022

Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

por Kuchenbaecker, Karoline, Gilly, Arthur, Suveges, Daniel, Southam, Lorraine, Giannakopoulou, Olga, Kilian, Britt, Tsafantakis, Emmanouil, Karaleftheri, Maria, Farmaki, Aliki-Eleni, Gurdasani, Deepti, Kundu, Kousik, Sandhu, Manjinder S., Danesh, John, Butterworth, Adam, Barroso, Inês, Dedoussis, George, Zeggini, Eleftheria
Publicado 2022

Very low-depth whole-genome sequencing in complex trait association studies

por Gilly, Arthur, Southam, Lorraine, Suveges, Daniel, Kuchenbaecker, Karoline, Moore, Rachel, Melloni, Giorgio E M, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Ritchie, Graham, Schwartzentruber, Jeremy, Danecek, Petr, Kilian, Britt, Pollard, Martin O, Ge, Xiangyu, Tsafantakis, Emmanouil, Dedoussis, George, Zeggini, Eleftheria
Publicado 2019

Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study

por Mamakou, Vasiliki, Hackinger, Sophie, Zengini, Eleni, Tsompanaki, Evgenia, Marouli, Eirini, Serafetinidis, Ioannis, Prins, Bram, Karabela, Athina, Glezou, Eirini, Southam, Lorraine, Rayner, Nigel W., Kuchenbaecker, Karoline, Lamnissou, Klea, Kontaxakis, Vassilis, Dedoussis, George, Gonidakis, Fragiskos, Thanopoulou, Anastasia, Tentolouris, Nikolaos, Zeggini, Eleftheria
Publicado 2018

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

por O’Loughlin, Jessica, Casanova, Francesco, Fairhurst-Hunter, Zammy, Hughes, Amanda, Bowden, Jack, Watkins, Edward R., Freathy, Rachel M., Millwood, Iona Y., Lin, Kuang, Chen, Zhengming, Li, Liming, Lv, Jun, Walters, Robin G., Howe, Laura D., Kuchenbaecker, Karoline, Tyrrell, Jessica
Publicado 2023

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

por Huang, Qin Qin, Sallah, Neneh, Dunca, Diana, Trivedi, Bhavi, Hunt, Karen A., Hodgson, Sam, Lambert, Samuel A., Arciero, Elena, Wright, John, Griffiths, Chris, Trembath, Richard C., Hemingway, Harry, Inouye, Michael, Finer, Sarah, van Heel, David A., Lumbers, R. Thomas, Martin, Hilary C., Kuchenbaecker, Karoline
Publicado 2022

Widespread genomic influences on phenotype in Dravet syndrome, a ‘monogenic’ condition

por Martins Custodio, Helena, Clayton, Lisa M, Bellampalli, Ravishankara, Pagni, Susanna, Silvennoinen, Katri, Caswell, Richard, Brunklaus, Andreas, Guerrini, Renzo, Koeleman, Bobby P C, Lemke, Johannes R, Møller, Rikke S, Scheffer, Ingrid E, Weckhuysen, Sarah, Zara, Federico, Zuberi, Sameer, Kuchenbaecker, Karoline, Balestrini, Simona, Mills, James D, Sisodiya, Sanjay M
Publicado 2023

Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

por Austin-Zimmerman, Isabelle, Levey, Daniel F., Giannakopoulou, Olga, Deak, Joseph D., Galimberti, Marco, Adhikari, Keyrun, Zhou, Hang, Denaxas, Spiros, Irizar, Haritz, Kuchenbaecker, Karoline, McQuillin, Andrew, Concato, John, Buysse, Daniel J., Gaziano, J. Michael, Gottlieb, Daniel J., Polimanti, Renato, Stein, Murray B., Bramon, Elvira, Gelernter, Joel
Publicado 2023

Transcriptome-wide association study reveals two genes that influence mismatch negativity

por Bhat, Anjali, Irizar, Haritz, Thygesen, Johan Hilge, Kuchenbaecker, Karoline, Pain, Oliver, Adams, Rick A., Zartaloudi, Eirini, Harju-Seppänen, Jasmine, Austin-Zimmerman, Isabelle, Wang, Baihan, Muir, Rebecca, Summerfelt, Ann, Du, Xiaoming Michael, Bruce, Heather, O’Donnell, Patricio, Srivastava, Deepak P., Friston, Karl, Hong, L. Elliot, Hall, Mei-Hua, Bramon, Elvira
Publicado 2021

The transferability of lipid loci across African, Asian and European cohorts

por Kuchenbaecker, Karoline, Telkar, Nikita, Reiker, Theresa, Walters, Robin G., Lin, Kuang, Eriksson, Anders, Gurdasani, Deepti, Gilly, Arthur, Southam, Lorraine, Tsafantakis, Emmanouil, Karaleftheri, Maria, Seeley, Janet, Kamali, Anatoli, Asiki, Gershim, Millwood, Iona Y., Holmes, Michael, Du, Huaidong, Guo, Yu, Kumari, Meena, Dedoussis, George, Li, Liming, Chen, Zhengming, Sandhu, Manjinder S., Zeggini, Eleftheria
Publicado 2019

Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers

por Borde, Julika, Laitman, Yael, Blümcke, Britta, Niederacher, Dieter, Weber-Lassalle, Konstantin, Sutter, Christian, Rump, Andreas, Arnold, Norbert, Wang-Gohrke, Shan, Horváth, Judit, Gehrig, Andrea, Schmidt, Gunnar, Dutrannoy, Véronique, Ramser, Juliane, Hentschel, Julia, Meindl, Alfons, Schroeder, Christopher, Wappenschmidt, Barbara, Engel, Christoph, Kuchenbaecker, Karoline, Schmutzler, Rita K., Friedman, Eitan, Hahnen, Eric, Ernst, Corinna
Publicado 2022