Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site

por Beyer, Hannes M., Mikula, Kornelia M., Kudling, Tatiana V., Iwaï, Hideo
Publicado 2019

Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control

por Quixabeira, Dafne C. A., Zafar, Sadia, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Kudling, Tatiana V., Basnet, Saru, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Publicado 2021

Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1

por Quixabeira, Dafne C. A., Cervera-Carrascon, Victor, Santos, Joao M., Clubb, James H.A., Kudling, Tatiana V., Basnet, Saru, Heiniö, Camilla, Grönberg-Vähä-Koskela, Susanna, Anttila, Marjukka, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli
Publicado 2022

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartmen...

por Pakola, Santeri, Quixabeira, Dafne C. A., Kudling, Tatiana V., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli
Publicado 2023

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

por Clubb, James H. A., Kudling, Tatiana V., Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C. A., Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli
Publicado 2022

Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors

por Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Publicado 2022

Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer

por Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli
Publicado 2023

Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression

por Kudling, Tatiana V., Clubb, James H.A., Quixabeira, Dafne C.A., Santos, Joao M., Havunen, Riikka, Kononov, Alexander, Heiniö, Camilla, Cervera-Carrascon, Victor, Pakola, Santeri, Basnet, Saru, Grönberg-Vähä-Koskela, Susanna, Arias, Victor, Gladwyn-Ng, Ivan, Aro, Katri, Bäck, Leif, Räsänen, Jari, Ilonen, Ilkka, Borenius, Kristian, Räsänen, Mikko, Hemminki, Otto, Rannikko, Antti, Kanerva, Anna, Tapper, Johanna, Hemminki, Akseli
Publicado 2022

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting

por Clubb, James H. A., Kudling, Tatiana V., Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C. A., Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli
Publicado 2023