Deposition of Aerosolized Lucinactant in Nonhuman Primates

por Gregory, Timothy J., Irshad, Hammad, Chand, Ramesh, Kuehl, Philip J.
Publicado 2020

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

por Kuehl, Philip J., Grimes, Marcie J., Dubose, Devon, Burke, Michael, Revelli, David A., Gigliotti, Andrew P., Belinsky, Steven A., Tessema, Mathewos
Publicado 2018

Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac(®)) in a Rodent Model

por Verco, James, Johnston, William, Baltezor, Michael, Kuehl, Philip J., Gigliotti, Andrew, Belinsky, Steven A., Lopez, Anita, Wolff, Ronald, Hylle, Lauren, diZerega, Gere
Publicado 2019

Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer

por Verco, James, Johnston, William, Frost, Michael, Baltezor, Michael, Kuehl, Philip J., Lopez, Anita, Gigliotti, Andrew, Belinsky, Steven A., Wolff, Ronald, diZerega, Gere
Publicado 2019

Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

por Kuehl, Philip J., Yingling, Christin M., Dubose, Devon, Burke, Michael, Revelli, David A., Chen, Wenshu, Dye, Wendy W., Belinsky, Steven A., Tessema, Mathewos
Publicado 2021

Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications

por Garcia, Andres, Mack, Peter, Williams, Stuart, Fromen, Catherine, Shen, Tammy, Tully, Janet, Pillai, Jonathan, Kuehl, Philip, Napier, Mary, DeSimone, Joseph M., Maynor, Benjamin W.
Publicado 2012

Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection

por Reed, Matthew D., Wilder, Julie A., Mega, William M., Hutt, Julie A., Kuehl, Philip J., Valderas, Michelle W., Chew, Lawrence L., Liang, Bertrand C., Squires, Charles H.
Publicado 2015

Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques

por Russo, Andrew T, Grosenbach, Douglas W, Brasel, Trevor L, Baker, Robert O, Cawthon, Andrew G, Reynolds, Erin, Bailey, Tara, Kuehl, Philip J, Sugita, Victoria, Agans, Krystle, Hruby, Dennis E
Publicado 2018

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

por Langel, Stephanie N., Johnson, Susan, Martinez, Clarissa I., Tedjakusuma, Sarah N., Peinovich, Nadine, Dora, Emery G., Kuehl, Philip J., Irshad, Hammad, Barrett, Edward G., Werts, Adam, Tucker, Sean N
Publicado 2022

Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation

por Shepard, Kimberly B., Vodak, David T., Kuehl, Philip J., Revelli, David, Zhou, Yue, Pluntze, Amanda M., Adam, Molly S., Oddo, Julia C., Switala, Lauren, Cape, Jonathan L., Baumann, John M., Banks, Michael
Publicado 2021

iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes

por Bäckman, Per, Cabal, Antonio, Clark, Andy, Ehrhardt, Carsten, Forbes, Ben, Hastedt, Jayne, Hickey, Anthony, Hochhaus, Guenther, Jiang, Wenlei, Kassinos, Stavros, Kuehl, Philip J., Prime, David, Son, Yoen-Ju, Teague, Simon P., Tehler, Ulrika, Wylie, Jennifer
Publicado 2022

iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System

por Hastedt, Jayne E., Bäckman, Per, Cabal, Antonio, Clark, Andy, Ehrhardt, Carsten, Forbes, Ben, Hickey, Anthony J., Hochhaus, Guenther, Jiang, Wenlei, Kassinos, Stavros, Kuehl, Philip J., Prime, David, Son, Yoen-Ju, Teague, Simon, Tehler, Ulrika, Wylie, Jennifer
Publicado 2022

5-Azacytidine inhaled dry powder formulation profoundly improves pharmacokinetics and efficacy for lung cancer therapy through genome reprogramming

por Kuehl, Philip J., Tellez, Carmen S., Grimes, Marcie J., March, Thomas H., Tessema, Mathewos, Revelli, David A., Mallis, Larry M., Dye, Wendy W., Sniegowski, Tyler, Badenoch, Aaron, Burke, Michael, Dubose, Devon, Vodak, David T., Picchi, Maria A., Belinsky, Steven A.
Publicado 2020

Reducing Aerosol-Related Risk of Transmission in the Era of COVID-19: An Interim Guidance Endorsed by the International Society of Aerosols in Medicine

por Fink, James B., Ehrmann, Stephan, Li, Jie, Dailey, Patricia, McKiernan, Paul, Darquenne, Chantal, Martin, Andrew R., Rothen-Rutishauser, Barbara, Kuehl, Philip J., Häussermann, Sabine, MacLoughlin, Ronan, Smaldone, Gerald C., Muellinger, Bernhard, Corcoran, Timothy E., Dhand, Rajiv
Publicado 2020

The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β(2)-adrenoceptor agonist in preclinical animal spe...

por Salmon, Michael, Tannheimer, Stacey L, Gentzler, Terry T, Cui, Zhi-Hua, Sorensen, Eric A, Hartsough, Kimberly C, Kim, Musong, Purvis, Lafe J, Barrett, Edward G, McDonald, Jacob D, Rudolph, Karin, Doyle-Eisele, Melanie, Kuehl, Philip J, Royer, Christopher M, Baker, William R, Phillips, Gary B, Wright, Clifford D
Publicado 2014

Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model

por Gomez, Mellissa, Ahmed, Mushtaq, Das, Shibali, McCollum, Joseph, Mellett, Leah, Swanson, Rosemary, Gupta, Ananya, Carrigy, Nicholas B., Wang, Hui, Barona, David, Bachchhav, Shital, Gerhardt, Alana, Press, Chris, Archer, Michelle C., Liang, Hong, Seydoux, Emilie, Kramer, Ryan M., Kuehl, Philip J., Vehring, Reinhard, Khader, Shabaana A., Fox, Christopher B.
Publicado 2022

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

por Vermillion, Meghan S., Murakami, Eisuke, Ma, Bin, Pitts, Jared, Tomkinson, Adrian, Rautiola, Davin, Babusis, Darius, Irshad, Hammad, Siegel, Dustin, Kim, Cynthia, Zhao, Xiaofeng, Niu, Congrong, Yang, Jesse, Gigliotti, Andrew, Kadrichu, Nani, Bilello, John P., Ellis, Scott, Bannister, Roy, Subramanian, Raju, Smith, Bill, Mackman, Richard L., Lee, William A., Kuehl, Philip J., Hartke, Jim, Cihlar, Tomas, Porter, Danielle P.
Publicado 2021